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Glycolipid transfer protein
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| PDB rendering based on 1swx. The Protein Data Bank ( PDB) is a repository for 3-D structural data of Proteins and Nucleic acids These data typically obtained by X-ray crystallography | ||
| Available structures: 1swx, 1sx6, 1tfj, 1wbe, 2bv7, 2euk, 2eum, 2evd, 2evl, 2evs, 2evt | ||
| Identifiers | ||
| Symbol(s) | GLTP; | |
| External IDs | OMIM: 608949 MGI: 1929253 HomoloGene: 41133 | |
| RNA expression pattern | ||
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| Orthologs | ||
| Human | Mouse | |
| Entrez | 51228 | 56356 |
| Ensembl | ENSG00000139433 | ENSMUSG00000011884 |
| Uniprot | Q9NZD2 | Q3U011 |
| Refseq | NM_016433 (mRNA) NP_057517 (protein) |
NM_019821 (mRNA) NP_062795 (protein) |
| Location | Chr 12: 108.77 - 108.8 Mb | Chr 5: 114.93 - 114.95 Mb |
| Pubmed search | [1] | [2] |
Glycolipid transfer protein, also known as GLTP, is a human gene. The Human Genome Organisation (HUGO is an organization involved in the Human Genome Project, a project about mapping the human genome The Mouse Genome Informatics (MGI website is run by The Jackson Laboratory. HomoloGene, a tool of the National Center for Biotechnology Information (NCBI is a system for automated detection of homologs (similarity attributable to descent The Entrez Global Query Cross-Database Search System is a powerful Federated search engine or Web portal that allows users to search many discrete Health sciences Ensembl is a joint scientific project between the European Bioinformatics Institute and the Wellcome Trust Sanger Institute, which was launched in 1999 in response to the imminent UniProt is the uni versal prot ein resource a central repository of Protein data created by combining Swiss-Prot, TrEMBL PubMed is a free search engine for accessing the MEDLINE database of citations and abstracts of biomedical research articles History See also History of genetics The existence of genes was first suggested by Gregor Mendel (1822-1884 who in the 1860s studied inheritance [1]
The protein encoded by this gene is similar to bovine and porcine proteins which accelerate transfer of certain glycosphingolipids and glyceroglycolipids between membranes. It is thought to be a cytoplasmic protein. [1]
References
Further reading
- Brown RE, Mattjus P (2007). "Glycolipid transfer proteins. ". Biochim. Biophys. Acta 1771 (6): 746-60. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 17320476.
- Abe A (1990). "Primary structure of glycolipid transfer protein from pig brain. ". J. Biol. Chem. 265 (17): 9634-7. PMID 2190982.
- Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery. ". Genome Res. 6 (9): 791-806. PMID 8889548.
- Mattjus P, Pike HM, Molotkovsky JG, Brown RE (2000). "Charged membrane surfaces impede the protein-mediated transfer of glycosphingolipids between phospholipid bilayers. ". Biochemistry 39 (5): 1067-75. PMID 10653652.
- Lin X, Mattjus P, Pike HM, et al. (2000). "Cloning and expression of glycolipid transfer protein from bovine and porcine brain. ". J. Biol. Chem. 275 (7): 5104-10. PMID 10671554.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. ". Proc. Natl. Acad. Sci. U. S. A. 99 (26): 16899-903. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 12477932.
- Li XM, Malakhova ML, Lin X, et al. (2004). "Human glycolipid transfer protein: probing conformation using fluorescence spectroscopy. ". Biochemistry 43 (31): 10285-94. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 15287756.
- Malinina L, Malakhova ML, Teplov A, et al. (2004). "Structural basis for glycosphingolipid transfer specificity. ". Nature 430 (7003): 1048-53. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 15329726.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). ". Genome Res. 14 (10B): 2121-7. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 15489334.
- Rao CS, Lin X, Pike HM, et al. (2004). "Glycolipid transfer protein mediated transfer of glycosphingolipids between membranes: a model for action based on kinetic and thermodynamic analyses. ". Biochemistry 43 (43): 13805-15. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 15504043.
- Malakhova ML, Malinina L, Pike HM, et al. (2005). "Point mutational analysis of the liganding site in human glycolipid transfer protein. Functionality of the complex. ". J. Biol. Chem. 280 (28): 26312-20. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 15901739.
- Rao CS, Chung T, Pike HM, Brown RE (2006). "Glycolipid transfer protein interaction with bilayer vesicles: modulation by changing lipid composition. ". Biophys. J. 89 (6): 4017-28. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 16169991.
- Malinina L, Malakhova ML, Kanack AT, et al. (2006). "The liganding of glycolipid transfer protein is controlled by glycolipid acyl structure. ". PLoS Biol. 4 (11): e362. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 17105344.
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