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Growth factor, augmenter of liver regeneration (ERV1 homolog, S. cerevisiae)
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| Identifiers | ||
| Symbol(s) | GFER; ERV1; ALR; HERV1; HPO; HPO1; HPO2; HSS | |
| External IDs | OMIM: 600924 MGI: 107757 HomoloGene: 55884 | |
| RNA expression pattern | ||
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| Orthologs | ||
| Human | Mouse | |
| Entrez | 2671 | 11692 |
| Ensembl | ENSG00000127554 | ENSMUSG00000040888 |
| Uniprot | P55789 | Q8CIF8 |
| Refseq | NM_005262 (mRNA) NP_005253 (protein) |
NM_023040 (mRNA) NP_075527 (protein) |
| Location | Chr 16: 1.97 - 1.98 Mb | Chr 17: 24.42 - 24.42 Mb |
| Pubmed search | [1] | [2] |
Growth factor, augmenter of liver regeneration (ERV1 homolog, S. The Human Genome Organisation (HUGO is an organization involved in the Human Genome Project, a project about mapping the human genome The Mouse Genome Informatics (MGI website is run by The Jackson Laboratory. HomoloGene, a tool of the National Center for Biotechnology Information (NCBI is a system for automated detection of homologs (similarity attributable to descent The Entrez Global Query Cross-Database Search System is a powerful Federated search engine or Web portal that allows users to search many discrete Health sciences Ensembl is a joint scientific project between the European Bioinformatics Institute and the Wellcome Trust Sanger Institute, which was launched in 1999 in response to the imminent UniProt is the uni versal prot ein resource a central repository of Protein data created by combining Swiss-Prot, TrEMBL PubMed is a free search engine for accessing the MEDLINE database of citations and abstracts of biomedical research articles cerevisiae), also known as GFER, is a human gene. History See also History of genetics The existence of genes was first suggested by Gregor Mendel (1822-1884 who in the 1860s studied inheritance [1]
The hepatotrophic factor designated augmenter of liver regeneration (ALR) is thought to be one of the factors responsible for the extraordinary regenerative capacity of mammalian liver. It has also been called hepatic regenerative stimulation substance (HSS). The gene resides on chromosome 16 in the interval containing the locus for polycystic kidney disease (PKD1). The putative gene product is 42% similar to the scERV1 protein of yeast. The yeast scERV1 gene had been found to be essential for oxidative phosphorylation, the maintenance of mitochondrial genomes, and the cell division cycle. The human gene is both the structural and functional homolog of the yeast scERV1 gene. [1]
References
Further reading
- Francavilla A, Hagiya M, Porter KA, et al. (1994). "Augmenter of liver regeneration: its place in the universe of hepatic growth factors. ". Hepatology 20 (3): 747-57. PMID 8076931.
- Gatzidou E, Kouraklis G, Theocharis S (2007). "Insights on augmenter of liver regeneration cloning and function. ". World J. Gastroenterol. 12 (31): 4951-8. PMID 16937489.
- Lisowsky T (1992). "Dual function of a new nuclear gene for oxidative phosphorylation and vegetative growth in yeast. ". Mol. Gen. Genet. 232 (1): 58-64. PMID 1552903.
- Renan MJ, Reeves BR (1987). "Chromosomal localization of human endogenous retroviral element ERV1 to 18q22----q23 by in situ hybridization. ". Cytogenet. Cell Genet. 44 (2-3): 167-70. PMID 3568764.
- O'Brien SJ, Bonner TI, Cohen M, et al. (1983). "Mapping of an endogenous retroviral sequence to human chromosome 18. ". Nature 303 (5912): 74-7. PMID 6843662.
- Lisowsky T, Weinstat-Saslow DL, Barton N, et al. (1996). "A new human gene located in the PKD1 region of chromosome 16 is a functional homologue to ERV1 of yeast. ". Genomics 29 (3): 690-7. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 8575761.
- Giorda R, Hagiya M, Seki T, et al. (1997). "Analysis of the structure and expression of the augmenter of liver regeneration (ALR) gene. ". Mol. Med. 2 (1): 97-108. PMID 8900538.
- Yang XM, Hu ZY, Xie L, et al. (1998). "[In vitro stimulation of HTC hepatoma cell growth by recombinant human augmenter of liver regeneration (ALR)]". Sheng li xue bao : [Acta physiologica Sinica] 49 (5): 557-61. PMID 9813496.
- Wang G, Yang X, Zhang Y, et al. (1999). "Identification and characterization of receptor for mammalian hepatopoietin that is homologous to yeast ERV1. ". J. Biol. Chem. 274 (17): 11469-72. PMID 10206950.
- Hofhaus G, Stein G, Polimeno L, et al. (1999). "Highly divergent amino termini of the homologous human ALR and yeast scERV1 gene products define species specific differences in cellular localization. ". Eur. J. Cell Biol. 78 (5): 349-56. PMID 10384986.
- Li Y, Li M, Xing G, et al. (2001). "Stimulation of the mitogen-activated protein kinase cascade and tyrosine phosphorylation of the epidermal growth factor receptor by hepatopoietin. ". J. Biol. Chem. 275 (48): 37443-7. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 10982794.
- Lu C, Li Y, Zhao Y, et al. (2002). "Intracrine hepatopoietin potentiates AP-1 activity through JAB1 independent of MAPK pathway. ". FASEB J. 16 (1): 90-2. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 11709497.
- Cheng J, Zhong YW, Liu Y, et al. . "Cloning and sequence analysis of human genomic DNA of augmenter of liver regeneration. " 6 (2): 275-277. PMID 11819575.
- Li Y, Xing G, Wang Q, et al. (2002). "Hepatopoietin acts as an autocrine growth factor in hepatoma cells. ". DNA Cell Biol. 20 (12): 791-5. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 11879572.
- Lu J, Xu WX, Zhan YQ, et al. (2002). "Identification and characterization of a novel isoform of hepatopoietin. ". World J. Gastroenterol. 8 (2): 353-6. PMID 11925624.
- Li Y, Wei K, Lu C, et al. (2002). "Identification of hepatopoietin dimerization, its interacting regions and alternative splicing of its transcription. ". Eur. J. Biochem. 269 (16): 3888-93. PMID 12180965.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. ". Proc. Natl. Acad. Sci. U. S. A. 99 (26): 16899-903. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 12477932.
- Zhao Y, Tang F, Cheng J, et al. (2003). "An initiator and its flanking elements function as a core promoter driving transcription of the Hepatopoietin gene. ". FEBS Lett. 540 (1-3): 58-64. PMID 12681483.
- Shen L, Hu J, Lu H, et al. (2003). "The apoptosis-associated protein BNIPL interacts with two cell proliferation-related proteins, MIF and GFER. ". FEBS Lett. 540 (1-3): 86-90. PMID 12681488.