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GENESIS (The GEneral NEural SImulation System) is a simulation environment for constructing realistic models of neurobiological systems at many levels of scale including subcellular processes, individual neurons, networks of neurons, and neuronal systems.

GENESIS was developed in the Caltech laboratory of Dr. The California Institute of Technology (commonly referred to as Caltech) is a private, Coeducational research university located in Pasadena James M. Bower, and first released to the public in 1988 in association with the first Methods in Computational Neuroscience Course at the Marine Biological Laboratory in Woods Hole, MA. James Mason Bower (born February 17, 1954, Northampton Massachusetts, USA is an American neuroscientist and CEO and Chairman of The Marine Biological Laboratory (MBL is an international center for research and education in biology and ecology Full source code for the software was released in the same year under an open software model for development. Open source software (OSS began as a marketing campaign for Free software. It's now supported by the Computational Biology Initiative at the University of Texas at San Antonio and is available for free along with tutorial guides on its use. The University of Texas at San Antonio (UTSA is San Antonio ’s largest public University and currently the second largest university in the University of Texas

P-GENESIS, a parallel version of GENESIS, was first run in 1990 on the Intel Delta, which was the prototype for the Intel Paragon family of massively parallel supercomputers. The Intel Paragon was a series of Massively parallel Supercomputers produced by Intel.

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