GDF may stand for:
- Grateful Dead Family
- Game Definition File, a file that describes a game to the Windows Vista Games Explorer
- Game Development Framework
- Gaz de France
- General Data Format for Biomedical Signals
- Geographic Data Files
- GEODraft Database File, a proprietary file format of the documents created by the GEODraft well log authoring application. Gaz de France (GDF was a French company which produced transported and sold Natural gas around the world especially in France its main market The General Data Format for Biomedical Signals is a scientific and medical data File format. Geographic Data Files or GDF is an interchange File format for geographic files
- Global Development Finance
- Gnutella Developers Forum
- Graphic Design File, a file produced by the Altera Quartus software as a logical design schematic
- Growth and differentiation factor - a subfamily of proteins belonging to the transforming growth factor beta superfamily
- Guides de France
- Guyana Defence Force
- Gurps Data File - An expansion file for the Gurps Character Assistant role playing aide. Growth differentiation factors (GDFs are a subfamily of proteins belonging to the Transforming growth factor beta superfamily that have functions predominantly in development Scouts et Guides de France ( Scouts and Guides of France, SGdF is the largest Scouting and Guiding association in France. The Guyana Defence Force (GDF is the military service of Guyana.
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