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Gamma-aminobutyric acid (GABA) receptor, rho 1
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| Identifiers | ||
| Symbol(s) | GABRR1; MGC163216 | |
| External IDs | OMIM: 137161 MGI: 95625 HomoloGene: 20470 | |
| RNA expression pattern | ||
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| Orthologs | ||
| Human | Mouse | |
| Entrez | 2569 | 14408 |
| Ensembl | ENSG00000146276 | ENSMUSG00000028280 |
| Uniprot | P24046 | P56475 |
| Refseq | NM_002042 (mRNA) NP_002033 (protein) |
NM_008075 (mRNA) NP_032101 (protein) |
| Location | Chr 6: 89.94 - 89.98 Mb | Chr 4: 33.46 - 33.49 Mb |
| Pubmed search | [1] | [2] |
Gamma-aminobutyric acid (GABA) receptor, rho 1, also known as GABRR1, is a human gene. The Human Genome Organisation (HUGO is an organization involved in the Human Genome Project, a project about mapping the human genome The Mouse Genome Informatics (MGI website is run by The Jackson Laboratory. HomoloGene, a tool of the National Center for Biotechnology Information (NCBI is a system for automated detection of homologs (similarity attributable to descent The Entrez Global Query Cross-Database Search System is a powerful Federated search engine or Web portal that allows users to search many discrete Health sciences Ensembl is a joint scientific project between the European Bioinformatics Institute and the Wellcome Trust Sanger Institute, which was launched in 1999 in response to the imminent UniProt is the uni versal prot ein resource a central repository of Protein data created by combining Swiss-Prot, TrEMBL PubMed is a free search engine for accessing the MEDLINE database of citations and abstracts of biomedical research articles History See also History of genetics The existence of genes was first suggested by Gregor Mendel (1822-1884 who in the 1860s studied inheritance [1]
GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA receptors, which are ligand-gated chloride channels. GABRR1 is a member of the rho subunit family. [1]
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See also
References
- ^ a b Entrez Gene: GABRR1 gamma-aminobutyric acid (GABA) receptor, rho 1. The GABAC receptor is one of two Ligand-gated ion channels responsible for mediating the effects of Gamma-Amino Butyric Acid ( GABA) the major inhibitory
Further reading
- Cutting GR, Curristin S, Zoghbi H, et al. (1992). "Identification of a putative gamma-aminobutyric acid (GABA) receptor subunit rho2 cDNA and colocalization of the genes encoding rho2 (GABRR2) and rho1 (GABRR1) to human chromosome 6q14-q21 and mouse chromosome 4. ". Genomics 12 (4): 801-6. PMID 1315307.
- Cutting GR, Lu L, O'Hara BF, et al. (1991). "Cloning of the gamma-aminobutyric acid (GABA) rho 1 cDNA: a GABA receptor subunit highly expressed in the retina. ". Proc. Natl. Acad. Sci. U. S. A. 88 (7): 2673-7. PMID 1849271.
- Wang TL, Hackam A, Guggino WB, Cutting GR (1995). "A single histidine residue is essential for zinc inhibition of GABA rho 1 receptors. ". J. Neurosci. 15 (11): 7684-91. PMID 7472519.
- Hackam AS, Wang TL, Guggino WB, Cutting GR (1997). "The N-terminal domain of human GABA receptor rho1 subunits contains signals for homooligomeric and heterooligomeric interaction. ". J. Biol. Chem. 272 (21): 13750-7. PMID 9153229.
- Kusama T, Hatama K, Sakurai M, et al. (1999). "Consensus phosphorylation sites of human GABA(c)/GABArho receptors are not critical for inhibition by protein kinase C activation. ". Neurosci. Lett. 255 (1): 17-20. PMID 9839716.
- Hanley JG, Koulen P, Bedford F, et al. (1999). "The protein MAP-1B links GABA(C) receptors to the cytoskeleton at retinal synapses. ". Nature 397 (6714): 66-9. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 9892354.
- Bailey ME, Albrecht BE, Johnson KJ, Darlison MG (1999). "Genetic linkage and radiation hybrid mapping of the three human GABA(C) receptor rho subunit genes: GABRR1, GABRR2 and GABRR3. ". Biochim. Biophys. Acta 1447 (2-3): 307-12. PMID 10542332.
- Hanley JG, Jones EM, Moss SJ (2000). "GABA receptor rho1 subunit interacts with a novel splice variant of the glycine transporter, GLYT-1. ". J. Biol. Chem. 275 (2): 840-6. PMID 10625616.
- Filippova N, Sedelnikova A, Zong Y, et al. (2000). "Regulation of recombinant gamma-aminobutyric acid (GABA)(A) and GABA(C) receptors by protein kinase C. ". Mol. Pharmacol. 57 (5): 847-56. PMID 10779366.
- Billups D, Hanley JG, Orme M, et al. (2001). "GABAC receptor sensitivity is modulated by interaction with MAP1B. ". J. Neurosci. 20 (23): 8643-50. PMID 11102469.
- Wang QW, Li ZW, Wang F, Yang JQ (2002). "Modulation by divalent cations of GABA rho 1 receptor from human retina expressed in Xenopus oocytes. ". Biomed. Environ. Sci. 14 (4): 269-77. PMID 11862606.
- Sedelnikova A, Weiss DS (2002). "Phosphorylation of the recombinant rho1 GABA receptor. ". Int. J. Dev. Neurosci. 20 (3-5): 237-46. PMID 12175859.
- Torres VI, Weiss DS (2003). "Identification of a tyrosine in the agonist binding site of the homomeric rho1 gamma-aminobutyric acid (GABA) receptor that, when mutated, produces spontaneous opening. ". J. Biol. Chem. 277 (46): 43741-8. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 12226075.
- Croci C, Brändstatter JH, Enz R (2003). "ZIP3, a new splice variant of the PKC-zeta-interacting protein family, binds to GABAC receptors, PKC-zeta, and Kv beta 2. ". J. Biol. Chem. 278 (8): 6128-35. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 12431995.
- Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6. ". Nature 425 (6960): 805-11. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 14574404.
- Boué-Grabot E, Emerit MB, Toulmé E, et al. (2004). "Cross-talk and co-trafficking between rho1/GABA receptors and ATP-gated channels. ". J. Biol. Chem. 279 (8): 6967-75. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 14660627.
- Martínez-Torres A, Miledi R (2004). "A single amino acid change within the ion-channel domain of the gamma-aminobutyric acid rho1 receptor accelerates desensitization and increases taurine agonism. ". Arch. Med. Res. 35 (3): 194-8. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 15163459.
- Sedelnikova A, Smith CD, Zakharkin SO, et al. (2005). "Mapping the rho1 GABA(C) receptor agonist binding pocket. Constructing a complete model. ". J. Biol. Chem. 280 (2): 1535-42. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 15548535.
- Song XQ, Meng F, Ramsey DJ, et al. (2006). "The GABA rho1 subunit interacts with a cellular retinoic acid binding protein in mammalian retina. ". Neuroscience 136 (2): 467-75. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 16198491.
External links
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