Portrait of Franz Nissl.

Franz Nissl (September 9, 1860 – August 11, 1919) was a German neuropathologist. Events 1000 - Battle of Svolder, Viking Age. 1379 - Treaty of Neuberg, splitting the Austrian Year 1860 ( MDCCLX) was a Leap year starting on Sunday (link will display the full calendar of the Gregorian Calendar (or a Leap year starting Events 2492 BC - Traditional date of the defeat of Bel by Hayk, progenitor and founder of the Armenian nation Year 1919 ( MCMXIX) was a Common year starting on Wednesday (link will display the full calendar of the Gregorian calendar (or a Common Germany, officially the Federal Republic of Germany ( ˈbʊndəsʁepuˌbliːk ˈdɔʏtʃlant is a Country in Central Europe. Neuropathology is the study of Disease of nervous system tissue usually in the form of either small surgical biopsies or whole autopsy brains

Life

Born in Frankenthal, Rhenish Palatinate, he did his medical studies in Munich where he became interested in the pathology of cortical neurons. Frankenthal is a City in southwestern Germany, in the state of Rhineland-Palatinate. The Palatinate (Pfalz Pfälzer dialect Palz) historically also Rhenish Palatinate (palatinatum Renensis Rheinpfalz is a region in south-western Germany The cerebral cortex is a structure within the Brain that plays a key role in Memory, Attention, perceptual Awareness, Thought, He is best known for developing a histological stain which allowed for selective visualization of neuronal cell bodies throughout the brain, ushering a new era in neurocytology and neuropathology. Neurons (ˈnjuːɹɒn also known as neurones and nerve cells) are responsive cells in the Nervous system that process and transmit information The soma, or cyton or perikaryon, is the bulbous end of a Neuron, containing the Cell nucleus. He also did important work in psychiatry correlating changes in glial cells, blood vessels, and brain tissue in general with mental illness. Glial cells, commonly called neuroglia or simply glia (Greek for "glue" are non- Neuronal cells that provide support and nutrition He also worked with and was friends with Alois Alzheimer. Aloysius "Alois" Alzheimer (14 June 1864 - 19 December 1915 was a German Psychiatrist and Neuropathologist and a colleague of Emil Kraepelin Toward the end of his life he studied the nature of the connections between the cerebral cortex and the thalamus. The cerebral cortex is a structure within the Brain that plays a key role in Memory, Attention, perceptual Awareness, Thought, The thalamus (from Greek θάλαμος = room chamber, IPA= /ˈθæləməs/ is a pair and symmetric part of the brain

Image of a Nissl-stained histological section through the rodent hippocampus showing various classes of neurons. Rodentia is an order of Mammals also known as rodents, characterised by two continuously-growing incisors in the upper and lower jaws which must The hippocampus is a part of the Forebrain, located in the medial Temporal lobe.

Named histology concepts

The Nissl method uses basic aniline to stain RNA blue, and is used to highlight important structural features of neurons. Aniline, phenylamine or aminobenzene is an Organic compound with the formula C6H7N Ribonucleic acid ( RNA) is a Nucleic acid that consists of a long chain of Nucleotide units The Nissl substance (rough endoplasmic reticulum) appears dark blue due to the staining of ribosomal RNA, giving the cytoplasm a mottled appearance. The endoplasmic reticulum (Greek endo = "within" (prefix plásma = "formed entity" Latin reticulum = "little net" or ER, is an Organelle Individual granules of extranuclear RNA are named Nissl granules (ribosomes). Ribosomes ( from ribo nucleic acid and "Greek soma ( meaning body") are complexes of RNA and Protein that DNA present in the nucleus stains a similar color. In Cell biology, the nucleus (pl nuclei; from Latin la ''nucleus'' or la ''nuculeus'' "little nut" or kernel is a membrane-enclosed

See also

• Nissl bodies

External links

• Biography of Franz Nissl
• More information from the University of Illinois at Chicago