Francis Sykes may refer to:

• Sir Francis Sykes, 1st Baronet (1732-1804), British diplomat, MP
• Sir Francis Sykes, 2nd Baronet (c. Sir Francis Sykes 1st Baronet (1732&ndash1804 was an English landowner Member of Parliament and sometime Governor of Kasimbazar in India, 1767-1804), MP Wallingford

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