Francis I may refer to:
- Francis I, Duke of Brittany (1414-1450, reigned 1442-1450). Francis I (in breton Fransez I, in french François I) ( Vannes /Gwened May 14 1414 &ndash July 18 1450, Château
- Francis I, Duke of Lorraine (1517–1545, reigned 1544–1545). Francis I ( August 23, 1517 – June 12 1545) was briefly Duke of Lorraine from 1544 until the following year
- Francis I of France (1494-1547, reigned 1515-1547). Francis I (September 12 1494 &ndash March 31 1547 was crowned King of France in 1515 in the cathedral at Reims and reigned until 1547
- Francesco I de' Medici, Grand Duke of Tuscany (1541-1587, reigned 1574-1587). Francesco I de' Medici Grand Duke of Tuscany ( 25 March 1541 &ndash 17 October 1587) was the second Grand Duke of Tuscany, ruling
- Francesco I d'Este, Duke of Modena (1644-1658). Francesco I d'Este ( September 6 1610 - October 14 1658) was Duke of Modena and Reggio from 1644 until his death
- Francis I, Holy Roman Emperor (1708-1765, reigned 1745-1765). Early life He was born in Nancy, Lorraine (now in France) the oldest surviving son of Leopold Joseph, duke of Lorraine and his wife
- Francis I, Emperor of Austria (1768-1835, reigned 1804-1835). Francis II (Franz II Heiliger Römischer Kaiser ( 12 February 1768 &ndash 2 March 1835) was the last Holy Roman Emperor, ruling
- Francis I of the Two Sicilies (1777-1830, reigned 1825-1830). Francis I ( Francesco Gennaro Giuseppe, August 14, 1777 &ndash November 8, 1830) was King of the Two Sicilies from
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