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Fucosyltransferase 9 (alpha (1,3) fucosyltransferase)
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| Identifiers | ||
| Symbol(s) | FUT9; Fuc-TIX | |
| External IDs | OMIM: 606865 MGI: 1330859 HomoloGene: 4800 | |
| RNA expression pattern | ||
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| Orthologs | ||
| Human | Mouse | |
| Entrez | 10690 | 14348 |
| Ensembl | ENSG00000172461 | ENSMUSG00000055373 |
| Uniprot | Q9Y231 | Q14AE3 |
| Refseq | NM_006581 (mRNA) NP_006572 (protein) |
NM_010243 (mRNA) NP_034373 (protein) |
| Location | Chr 6: 96.57 - 96.76 Mb | Chr 4: 25.7 - 25.89 Mb |
| Pubmed search | [1] | [2] |
Fucosyltransferase 9 (alpha (1,3) fucosyltransferase), also known as FUT9, is a human gene. The Human Genome Organisation (HUGO is an organization involved in the Human Genome Project, a project about mapping the human genome The Mouse Genome Informatics (MGI website is run by The Jackson Laboratory. HomoloGene, a tool of the National Center for Biotechnology Information (NCBI is a system for automated detection of homologs (similarity attributable to descent The Entrez Global Query Cross-Database Search System is a powerful Federated search engine or Web portal that allows users to search many discrete Health sciences Ensembl is a joint scientific project between the European Bioinformatics Institute and the Wellcome Trust Sanger Institute, which was launched in 1999 in response to the imminent UniProt is the uni versal prot ein resource a central repository of Protein data created by combining Swiss-Prot, TrEMBL PubMed is a free search engine for accessing the MEDLINE database of citations and abstracts of biomedical research articles History See also History of genetics The existence of genes was first suggested by Gregor Mendel (1822-1884 who in the 1860s studied inheritance [1]
FUT9 is one of several alpha-3-fucosyltransferases that can catalyze the last step in the biosynthesis of Lewis antigen, the addition of a fucose to precursor polysaccharides. FUT9 synthesizes the LeX oligosaccharide (CD15), which is expressed in organ buds progressing in mesenchyma during human embryogenesis. [supplied by OMIM][1]
References
Further reading
- Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery. ". Genome Res. 6 (9): 791–806. PMID 8889548.
- Kaneko M, Kudo T, Iwasaki H, et al. (1999). "Alpha1,3-fucosyltransferase IX (Fuc-TIX) is very highly conserved between human and mouse; molecular cloning, characterization and tissue distribution of human Fuc-TIX. ". FEBS Lett. 452 (3): 237–42. PMID 10386598.
- Kaneko M, Kudo T, Iwasaki H, et al. (2000). "Assignment of the human alpha 1,3-fucosyltransferase IX gene (FUT9) to chromosome band 6q16 by in situ hybridization. ". Cytogenet. Cell Genet. 86 (3-4): 329–30. PMID 10575236.
- Nishihara S, Iwasaki H, Kaneko M, et al. (2000). "Alpha1,3-fucosyltransferase 9 (FUT9; Fuc-TIX) preferentially fucosylates the distal GlcNAc residue of polylactosamine chain while the other four alpha1,3FUT members preferentially fucosylate the inner GlcNAc residue. ". FEBS Lett. 462 (3): 289–94. PMID 10622713.
- Cailleau-Thomas A, Coullin P, Candelier JJ, et al. (2000). "FUT4 and FUT9 genes are expressed early in human embryogenesis. ". Glycobiology 10 (8): 789–802. PMID 10929005.
- Nakayama F, Nishihara S, Iwasaki H, et al. (2001). "CD15 expression in mature granulocytes is determined by alpha 1,3-fucosyltransferase IX, but in promyelocytes and monocytes by alpha 1,3-fucosyltransferase IV. ". J. Biol. Chem. 276 (19): 16100–6. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 11278338.
- Roos C, Kolmer M, Mattila P, Renkonen R (2002). "Composition of Drosophila melanogaster proteome involved in fucosylated glycan metabolism. ". J. Biol. Chem. 277 (5): 3168–75. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 11698403.
- Toivonen S, Nishihara S, Narimatsu H, et al. (2003). "Fuc-TIX: a versatile alpha1,3-fucosyltransferase with a distinct acceptor- and site-specificity profile. ". Glycobiology 12 (6): 361–8. PMID 12107078.
- Li H, Kong Y, Yan B (2003). "[Regulation by ovarian hormones of alpha 1,3-fucosyltransferase gene (FUT9) expression in human endometrium]". Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao 34 (6): 775–9. PMID 12417923.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. ". Proc. Natl. Acad. Sci. U. S. A. 99 (26): 16899–903. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 12477932.
- Nishihara S, Iwasaki H, Nakajima K, et al. (2004). "Alpha1,3-fucosyltransferase IX (Fut9) determines Lewis X expression in brain. ". Glycobiology 13 (6): 445–55. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 12626397.
- Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6. ". Nature 425 (6960): 805–11. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 14574404.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). ". Genome Res. 14 (10B): 2121–7. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 15489334.
- Bogoevska V, Horst A, Klampe B, et al. (2006). "CEACAM1, an adhesion molecule of human granulocytes, is fucosylated by fucosyltransferase IX and interacts with DC-SIGN of dendritic cells via Lewis x residues. ". Glycobiology 16 (3): 197–209. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 16282604.
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