|
FOS-like antigen 1
|
||
| Identifiers | ||
| Symbol(s) | FOSL1; FRA1; fra-1 | |
| External IDs | OMIM: 136515 MGI: 107179 HomoloGene: 3967 | |
| RNA expression pattern | ||
|
|
||
| Orthologs | ||
| Human | Mouse | |
| Entrez | 8061 | 14283 |
| Ensembl | ENSG00000175592 | ENSMUSG00000024912 |
| Uniprot | P15407 | Q3UMA0 |
| Refseq | NM_005438 (mRNA) NP_005429 (protein) |
NM_010235 (mRNA) NP_034365 (protein) |
| Location | Chr 11: 65.42 - 65.42 Mb | Chr 19: 5.45 - 5.46 Mb |
| Pubmed search | [1] | [2] |
FOS-like antigen 1, also known as FOSL1, is a human gene. The Human Genome Organisation (HUGO is an organization involved in the Human Genome Project, a project about mapping the human genome The Mouse Genome Informatics (MGI website is run by The Jackson Laboratory. HomoloGene, a tool of the National Center for Biotechnology Information (NCBI is a system for automated detection of homologs (similarity attributable to descent The Entrez Global Query Cross-Database Search System is a powerful Federated search engine or Web portal that allows users to search many discrete Health sciences Ensembl is a joint scientific project between the European Bioinformatics Institute and the Wellcome Trust Sanger Institute, which was launched in 1999 in response to the imminent UniProt is the uni versal prot ein resource a central repository of Protein data created by combining Swiss-Prot, TrEMBL PubMed is a free search engine for accessing the MEDLINE database of citations and abstracts of biomedical research articles History See also History of genetics The existence of genes was first suggested by Gregor Mendel (1822-1884 who in the 1860s studied inheritance [1]
The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. [1]
Contents |
See also
- AP-1 (transcription factor)
References
Further reading
- Herdegen T, Leah JD (1999). "Inducible and constitutive transcription factors in the mammalian nervous system: control of gene expression by Jun, Fos and Krox, and CREB/ATF proteins. ". Brain Res. Brain Res. Rev. 28 (3): 370–490. PMID 9858769.
- Reddy SP, Mossman BT (2002). "Role and regulation of activator protein-1 in toxicant-induced responses of the lung. ". Am. J. Physiol. Lung Cell Mol. Physiol. 283 (6): L1161–78. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 12424143.
- Matsui M, Tokuhara M, Konuma Y, et al. (1990). "Isolation of human fos-related genes and their expression during monocyte-macrophage differentiation. ". Oncogene 5 (3): 249–55. PMID 2107490.
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. ". Gene 138 (1-2): 171–4. PMID 8125298.
- Tsuchiya H, Fujii M, Niki T, et al. (1993). "Human T-cell leukemia virus type 1 Tax activates transcription of the human fra-1 gene through multiple cis elements responsive to transmembrane signals. ". J. Virol. 67 (12): 7001–7. PMID 8230424.
- Sinke RJ, Tanigami A, Nakamura Y, Geurts van Kessel A (1994). "Reverse mapping of the gene encoding the human fos-related antigen-1 (fra-1) within chromosome band 11q13. ". Genomics 18 (1): 165. PMID 8276409.
- Courseaux A, Grosgeorge J, Gaudray P, et al. (1997). "Definition of the minimal MEN1 candidate area based on a 5-Mb integrated map of proximal 11q13. The European Consortium on Men1, (GENEM 1; Groupe d'Etude des Néoplasies Endocriniennes Multiples de type 1). ". Genomics 37 (3): 354–65. PMID 8938448.
- Arts J, Herr I, Lansink M, et al. (1997). "Cell-type specific DNA-protein interactions at the tissue-type plasminogen activator promoter in human endothelial and HeLa cells in vivo and in vitro. ". Nucleic Acids Res. 25 (2): 311–7. PMID 9016559.
- Pognonec P, Boulukos KE, Aperlo C, et al. (1997). "Cross-family interaction between the bHLHZip USF and bZip Fra1 proteins results in down-regulation of AP1 activity. ". Oncogene 14 (17): 2091–8. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 9160889.
- Smith CM, Ma NS, Nowak NJ, et al. (1997). "A 3-Mb contig from D11S987 to MLK3, a gene-rich region in 11q13. ". Genome Res. 7 (8): 835–42. PMID 9267807.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. ". Gene 200 (1-2): 149–56. PMID 9373149.
- Puntschart A, Wey E, Jostarndt K, et al. (1998). "Expression of fos and jun genes in human skeletal muscle after exercise. ". Am. J. Physiol. 274 (1 Pt 1): C129–37. PMID 9458721.
- Finzer P, Soto U, Delius H, et al. (2000). "Differential transcriptional regulation of the monocyte-chemoattractant protein-1 (MCP-1) gene in tumorigenic and non-tumorigenic HPV 18 positive cells: the role of the chromatin structure and AP-1 composition. ". Oncogene 19 (29): 3235–44. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 10918580.
- Udalova IA, Kwiatkowski D (2001). "Interaction of AP-1 with a cluster of NF-kappa B binding elements in the human TNF promoter region. ". Biochem. Biophys. Res. Commun. 289 (1): 25–33. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 11708771.
- Jardine H, MacNee W, Donaldson K, Rahman I (2002). "Molecular mechanism of transforming growth factor (TGF)-beta1-induced glutathione depletion in alveolar epithelial cells. Involvement of AP-1/ARE and Fra-1. ". J. Biol. Chem. 277 (24): 21158–66. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 11912197.
- Wang HL, Wang J, Xiao SY, et al. (2002). "Elevated protein expression of cyclin D1 and Fra-1 but decreased expression of c-Myc in human colorectal adenocarcinomas overexpressing beta-catenin. ". Int. J. Cancer 101 (4): 301–10. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 12209953.
- Bergman MR, Cheng S, Honbo N, et al. (2003). "A functional activating protein 1 (AP-1) site regulates matrix metalloproteinase 2 (MMP-2) transcription by cardiac cells through interactions with JunB-Fra1 and JunB-FosB heterodimers. ". Biochem. J. 369 (Pt 3): 485–96. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 12371906.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. ". Proc. Natl. Acad. Sci. U. S. A. 99 (26): 16899–903. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 12477932.
External links
This article incorporates text from the United States National Library of Medicine, which is in the public domain. Medical Subject Headings ( MeSH) is a huge Controlled vocabulary (or metadata system for the purpose of indexing journal articles and books The United States National Library of Medicine ( NLM) operated by the United States federal government, is the world's largest Medical library. The public domain is a range of abstract materials &ndash commonly referred to as Intellectual property &ndash which are not owned or controlled by anyone
Dapyx Software network: MP3 Explorer | Ebook Manager | Zenithic