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Formin binding protein 1-like
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| Identifiers | ||
| Symbol(s) | FNBP1L; C1orf39; TOCA1 | |
| External IDs | OMIM: 608848 MGI: 1925642 HomoloGene: 20898 | |
| Orthologs | ||
| Human | Mouse | |
| Entrez | 54874 | 214459 |
| Ensembl | ENSG00000137942 | ENSMUSG00000039735 |
| Uniprot | Q5T0N5 | Q8K012 |
| Refseq | NM_001024948 (mRNA) NP_001020119 (protein) |
NM_153118 (mRNA) NP_694758 (protein) |
| Location | Chr 1: 93.69 - 93.79 Mb | Chr 3: 122.53 - 122.58 Mb |
| Pubmed search | [1] | [2] |
Formin binding protein 1-like, also known as FNBP1L, is a human gene. The Human Genome Organisation (HUGO is an organization involved in the Human Genome Project, a project about mapping the human genome The Mouse Genome Informatics (MGI website is run by The Jackson Laboratory. HomoloGene, a tool of the National Center for Biotechnology Information (NCBI is a system for automated detection of homologs (similarity attributable to descent The Entrez Global Query Cross-Database Search System is a powerful Federated search engine or Web portal that allows users to search many discrete Health sciences Ensembl is a joint scientific project between the European Bioinformatics Institute and the Wellcome Trust Sanger Institute, which was launched in 1999 in response to the imminent UniProt is the uni versal prot ein resource a central repository of Protein data created by combining Swiss-Prot, TrEMBL PubMed is a free search engine for accessing the MEDLINE database of citations and abstracts of biomedical research articles History See also History of genetics The existence of genes was first suggested by Gregor Mendel (1822-1884 who in the 1860s studied inheritance [1]
The protein encoded by this gene binds to both CDC42 and N-WASP. This protein promotes CDC42-induced actin polymerization by activating the N-WASP-WIP complex and, therefore, is involved in a pathway that links cell surface signals to the actin cytoskeleton. Alternative splicing results in multiple transcript variants encoding different isoforms. [1]
References
Further reading
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. ". Proc. Natl. Acad. Sci. U. S. A. 99 (26): 16899–903. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 12477932.
- Katoh M, Katoh M (2004). "Identification and characterization of human FNBP1L gene in silico. ". Int. J. Mol. Med. 13 (1): 157–62. PMID 14654988.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs. ". Nat. Genet. 36 (1): 40–5. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 14702039.
- Ho HY, Rohatgi R, Lebensohn AM, et al. (2004). "Toca-1 mediates Cdc42-dependent actin nucleation by activating the N-WASP-WIP complex. ". Cell 118 (2): 203–16. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 15260990.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). ". Genome Res. 14 (10B): 2121–7. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 15489334.
- Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome. ". Cell 122 (6): 957–68. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 16169070.
- Itoh T, Erdmann KS, Roux A, et al. (2006). "Dynamin and the actin cytoskeleton cooperatively regulate plasma membrane invagination by BAR and F-BAR proteins. ". Dev. Cell 9 (6): 791–804. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 16326391.
- Tsujita K, Suetsugu S, Sasaki N, et al. (2006). "Coordination between the actin cytoskeleton and membrane deformation by a novel membrane tubulation domain of PCH proteins is involved in endocytosis. ". J. Cell Biol. 172 (2): 269–79. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 16418535.
- Aspenström P, Richnau N, Johansson AS (2006). "The diaphanous-related formin DAAM1 collaborates with the Rho GTPases RhoA and Cdc42, CIP4 and Src in regulating cell morphogenesis and actin dynamics. ". Exp. Cell Res. 312 (12): 2180–94. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 16630611.
- Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1. ". Nature 441 (7091): 315–21. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 16710414.
- Kovacs EM, Makar RS, Gertler FB (2006). "Tuba stimulates intracellular N-WASP-dependent actin assembly. ". J. Cell. Sci. 119 (Pt 13): 2715–26. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 16757518.
- Kakimoto T, Katoh H, Negishi M (2006). "Regulation of neuronal morphology by Toca-1, an F-BAR/EFC protein that induces plasma membrane invagination. ". J. Biol. Chem. 281 (39): 29042–53. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 16885158.
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