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Fructosamine 3 kinase
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| Identifiers | ||
| Symbol(s) | FN3K; | |
| External IDs | OMIM: 608425 MGI: 1926834 HomoloGene: 23336 | |
| RNA expression pattern | ||
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| Orthologs | ||
| Human | Mouse | |
| Entrez | 64122 | 63828 |
| Ensembl | ENSG00000167363 | ENSMUSG00000025175 |
| Uniprot | Q9H479 | Q9ER35 |
| Refseq | NM_022158 (mRNA) NP_071441 (protein) |
NM_001038699 (mRNA) NP_001033788 (protein) |
| Location | Chr 17: 78.29 - 78.3 Mb | Chr 11: 121.25 - 121.27 Mb |
| Pubmed search | [1] | [2] |
Fructosamine 3 kinase, also known as FN3K, is a human gene. The Human Genome Organisation (HUGO is an organization involved in the Human Genome Project, a project about mapping the human genome The Mouse Genome Informatics (MGI website is run by The Jackson Laboratory. HomoloGene, a tool of the National Center for Biotechnology Information (NCBI is a system for automated detection of homologs (similarity attributable to descent The Entrez Global Query Cross-Database Search System is a powerful Federated search engine or Web portal that allows users to search many discrete Health sciences Ensembl is a joint scientific project between the European Bioinformatics Institute and the Wellcome Trust Sanger Institute, which was launched in 1999 in response to the imminent UniProt is the uni versal prot ein resource a central repository of Protein data created by combining Swiss-Prot, TrEMBL PubMed is a free search engine for accessing the MEDLINE database of citations and abstracts of biomedical research articles History See also History of genetics The existence of genes was first suggested by Gregor Mendel (1822-1884 who in the 1860s studied inheritance [1]
FN3K catalyzes phosphorylation of fructosamines formed by glycation, the nonenzymatic reaction of glucose with primary amines followed by Amadori rearrangement. Phosphorylation of fructosamines may initiate metabolism of the modified amine and result in deglycation of glycated proteins (Delpierre et al. , 2000). [supplied by OMIM][1]
References
Further reading
- Delpierre G, Rider MH, Collard F, et al. (2000). "Identification, cloning, and heterologous expression of a mammalian fructosamine-3-kinase. ". Diabetes 49 (10): 1627-34. PMID 11016445.
- Szwergold BS, Howell S, Beisswenger PJ (2001). "Human fructosamine-3-kinase: purification, sequencing, substrate specificity, and evidence of activity in vivo. ". Diabetes 50 (9): 2139-47. PMID 11522682.
- Delpierre G, Collard F, Fortpied J, Van Schaftingen E (2002). "Fructosamine 3-kinase is involved in an intracellular deglycation pathway in human erythrocytes. ". Biochem. J. 365 (Pt 3): 801-8. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 11975663.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. ". Proc. Natl. Acad. Sci. U. S. A. 99 (26): 16899-903. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 12477932.
- Delpierre G, Van Schaftingen E (2004). "Fructosamine 3-kinase, an enzyme involved in protein deglycation. ". Biochem. Soc. Trans. 31 (Pt 6): 1354-7. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 14641062.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs. ". Nat. Genet. 36 (1): 40-5. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 14702039.
- Delpierrre G, Vertommen D, Communi D, et al. (2004). "Identification of fructosamine residues deglycated by fructosamine-3-kinase in human hemoglobin. ". J. Biol. Chem. 279 (26): 27613-20. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 15102834.
- Delplanque J, Delpierre G, Opperdoes FR, Van Schaftingen E (2004). "Tissue distribution and evolution of fructosamine 3-kinase and fructosamine 3-kinase-related protein. ". J. Biol. Chem. 279 (45): 46606-13. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 15331600.
- Conner JR, Beisswenger PJ, Szwergold BS (2004). "The expression of the genes for fructosamine-3-kinase and fructosamine-3-kinase-related protein appears to be constitutive and unaffected by environmental signals. ". Biochem. Biophys. Res. Commun. 323 (3): 932-6. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 15381090.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). ". Genome Res. 14 (10B): 2121-7. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 15489334.
- Conner JR, Beisswenger PJ, Szwergold BS (2005). "Some clues as to the regulation, expression, function, and distribution of fructosamine-3-kinase and fructosamine-3-kinase-related protein. ". Ann. N. Y. Acad. Sci. 1043: 824-36. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 16037310.
- Delpierre G, Veiga-da-Cunha M, Vertommen D, et al. (2006). "Variability in erythrocyte fructosamine 3-kinase activity in humans correlates with polymorphisms in the FN3K gene and impacts on haemoglobin glycation at specific sites. ". Diabetes Metab. 32 (1): 31-9. PMID 16523184.
- Szwergold BS (2007). "Fructosamine-6-phosphates are deglycated by phosphorylation to fructosamine-3,6-bisphosphates catalyzed by fructosamine-3-kinase (FN3K) and/or fructosamine-3-kinase-related-protein (FN3KRP). ". Med. Hypotheses 68 (1): 37-45. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 16920277.
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