| FMN riboswitch (RFN element) | ||||||||||
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The FMN riboswitch (also known as RFN element) is a highly conserved RNA element that is found frequently in the 5'-untranslated regions of prokaryotic mRNAs that encode for flavin mononucleotide (FMN) biosynthesis and transport proteins. Nucleotides are Organic compounds that consist of three joined structures a nitrogenous base a Sugar, and a Phosphate group A cis-regulatory element or cis-element is a region of DNA or RNA that regulates the expression of Genes located on that same strand The five prime untranslated region ( 5' UTR) also known as the leader sequence, is a particular section of Messenger RNA (mRNA and the DNA that codes for Messenger ribonucleic acid ( mRNA) is a molecule of RNA encoding a chemical "blueprint" for a Protein product Flavin mononucleotide (FMN or riboflavin-5′-phosphate, is produced from Riboflavin (vitamin B2 by the enzyme Riboflavin kinase and This element is a metabolite-dependent riboswitch that directly binds FMN in the absence of proteins. In Molecular biology, a riboswitch is a part of an MRNA molecule that can directly bind a small target molecule, and whose binding of the target affects In Bacillus subtilis, the riboswitch most likely controls gene expression by causing premature transcription termination within the 5' untranslated region of the ribDEAHT operon and precluding access to the ribosome-binding site of ypaA mRNA. Bacillus subtilis Sporejpg|thumb|right|Sporulating Bacillus subtilis ]] Bacillus subtilis is a Gram-positive, Catalase -positive [1]
References
- ^ Winkler, WC; Cohen-Chalamish S, Breaker RR (2002). "An mRNA structure that controls gene expression by binding FMN". Proc Natl Acad Sci U S A 99: 15908–15913. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 12456892.
- Vitreschak, AG; Rodionov DA, Mironov AA, Gelfand MS (2002). "Regulation of riboflavin biosynthesis and transport genes in bacteria by transcriptional and translational attenuation". Nucleic Acids Res 30: 3141–3151. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 12136096.
- Gelfand, MS; Mironov AA, Jomantas J, Kozlov YI, Perumov DA (1999). "A conserved RNA structure element involved in the regulation of bacterial riboflavin synthesis genes". Trends Genet 15: 439–442. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 10529804.
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