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Formin homology 2 domain containing 1
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| Identifiers | ||
| Symbol(s) | FHOD1; FHOS | |
| External IDs | OMIM: 606881 MGI: 2679008 HomoloGene: 40860 | |
| RNA expression pattern | ||
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| Orthologs | ||
| Human | Mouse | |
| Entrez | 29109 | 234686 |
| Ensembl | ENSG00000135723 | ENSMUSG00000014778 |
| Uniprot | Q9Y613 | Q6P9Q4 |
| Refseq | NM_013241 (mRNA) NP_037373 (protein) |
NM_177699 (mRNA) NP_808367 (protein) |
| Location | Chr 16: 65.82 - 65.84 Mb | Chr 8: 108.22 - 108.24 Mb |
| Pubmed search | [1] | [2] |
Formin homology 2 domain containing 1, also known as FHOD1, is a human gene. The Human Genome Organisation (HUGO is an organization involved in the Human Genome Project, a project about mapping the human genome The Mouse Genome Informatics (MGI website is run by The Jackson Laboratory. HomoloGene, a tool of the National Center for Biotechnology Information (NCBI is a system for automated detection of homologs (similarity attributable to descent The Entrez Global Query Cross-Database Search System is a powerful Federated search engine or Web portal that allows users to search many discrete Health sciences Ensembl is a joint scientific project between the European Bioinformatics Institute and the Wellcome Trust Sanger Institute, which was launched in 1999 in response to the imminent UniProt is the uni versal prot ein resource a central repository of Protein data created by combining Swiss-Prot, TrEMBL PubMed is a free search engine for accessing the MEDLINE database of citations and abstracts of biomedical research articles History See also History of genetics The existence of genes was first suggested by Gregor Mendel (1822-1884 who in the 1860s studied inheritance [1]
This gene encodes a protein which is a member of the formin/diaphanous family of proteins. The gene is ubiquitously expressed but is found in abundance in the spleen. The encoded protein has sequence homology to diaphanous and formin proteins within the Formin Homology (FH)1 and FH2 domains. It also contains a coiled-coil domain, a collagen-like domain, two nuclear localization signals, and several potential PKC and PKA phosphorylation sites. It is a predominantly cytoplasmic protein and is expressed in a variety of human cell lines. [1]
References
Further reading
- Westendorf JJ, Mernaugh R, Hiebert SW (1999). "Identification and characterization of a protein containing formin homology (FH1/FH2) domains. ". Gene 232 (2): 173-82. PMID 10352228.
- Westendorf JJ (2002). "The formin/diaphanous-related protein, FHOS, interacts with Rac1 and activates transcription from the serum response element. ". J. Biol. Chem. 276 (49): 46453-9. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 11590143.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. ". Proc. Natl. Acad. Sci. U. S. A. 99 (26): 16899-903. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 12477932.
- Koka S, Neudauer CL, Li X, et al. (2004). "The formin-homology-domain-containing protein FHOD1 enhances cell migration. ". J. Cell. Sci. 116 (Pt 9): 1745-55. PMID 12665555.
- Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. ". Nat. Biotechnol. 21 (5): 566-9. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 12665801.
- Tojo H, Kaieda I, Hattori H, et al. (2004). "The Formin family protein, formin homolog overexpressed in spleen, interacts with the insulin-responsive aminopeptidase and profilin IIa. ". Mol. Endocrinol. 17 (7): 1216-29. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 12677009.
- Takeya R, Sumimoto H (2004). "Fhos, a mammalian formin, directly binds to F-actin via a region N-terminal to the FH1 domain and forms a homotypic complex via the FH2 domain to promote actin fiber formation. ". J. Cell. Sci. 116 (Pt 22): 4567-75. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 14576350.
- Lehner B, Semple JI, Brown SE, et al. (2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region. ". Genomics 83 (1): 153-67. PMID 14667819.
- Katoh M, Katoh M (2004). "Identification and characterization of human FHOD3 gene in silico. ". Int. J. Mol. Med. 13 (4): 615-20. PMID 15010865.
- Wang Y, El-Zaru MR, Surks HK, Mendelsohn ME (2004). "Formin homology domain protein (FHOD1) is a cyclic GMP-dependent protein kinase I-binding protein and substrate in vascular smooth muscle cells. ". J. Biol. Chem. 279 (23): 24420-6. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 15051728.
- Westendorf JJ, Koka S (2004). "Identification of FHOD1-binding proteins and mechanisms of FHOD1-regulated actin dynamics. ". J. Cell. Biochem. 92 (1): 29-41. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 15095401.
- Gill MB, Roecklein-Canfield J, Sage DR, et al. (2005). "EBV attachment stimulates FHOS/FHOD1 redistribution and co-aggregation with CD21: formin interactions with the cytoplasmic domain of human CD21. ". J. Cell. Sci. 117 (Pt 13): 2709-20. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 15138285.
- Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. ". Nat. Biotechnol. 22 (6): 707-16. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 15146197.
- Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation. ". Genome Res. 14 (7): 1315-23. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 15231747.
- Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins. ". Proc. Natl. Acad. Sci. U. S. A. 101 (33): 12130-5. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 15302935.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). ". Genome Res. 14 (10B): 2121-7. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 15489334.
- Madrid R, Gasteier JE, Bouchet J, et al. (2005). "Oligomerization of the diaphanous-related formin FHOD1 requires a coiled-coil motif critical for its cytoskeletal and transcriptional activities. ". FEBS Lett. 579 (2): 441-8. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 15642356.
- Gasteier JE, Schroeder S, Muranyi W, et al. (2005). "FHOD1 coordinates actin filament and microtubule alignment to mediate cell elongation. ". Exp. Cell Res. 306 (1): 192-202. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 15878344.
- Boehm MB, Milius TJ, Zhou Y, et al. (2005). "The mammalian formin FHOD1 interacts with the ERK MAP kinase pathway. ". Biochem. Biophys. Res. Commun. 335 (4): 1090-4. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 16112087.
- Schönichen A, Alexander M, Gasteier JE, et al. (2006). "Biochemical characterization of the diaphanous autoregulatory interaction in the formin homology protein FHOD1. ". J. Biol. Chem. 281 (8): 5084-93. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 16361249.