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Fibroblast growth factor receptor-like 1
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| Identifiers | ||
| Symbol(s) | FGFRL1; FGFR5; FHFR | |
| External IDs | OMIM: 605830 MGI: 2150920 HomoloGene: 11067 | |
| RNA expression pattern | ||
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| Orthologs | ||
| Human | Mouse | |
| Entrez | 53834 | 116701 |
| Ensembl | ENSG00000127418 | ENSMUSG00000008090 |
| Uniprot | Q8N441 | Q91V87 |
| Refseq | NM_001004356 (mRNA) NP_001004356 (protein) |
XM_983846 (mRNA) XP_988940 (protein) |
| Location | Chr 4: 1 - 1.01 Mb | Chr 5: 108.93 - 108.95 Mb |
| Pubmed search | [1] | [2] |
Fibroblast growth factor receptor-like 1, also known as FGFRL1, is a human gene. The Human Genome Organisation (HUGO is an organization involved in the Human Genome Project, a project about mapping the human genome The Mouse Genome Informatics (MGI website is run by The Jackson Laboratory. HomoloGene, a tool of the National Center for Biotechnology Information (NCBI is a system for automated detection of homologs (similarity attributable to descent The Entrez Global Query Cross-Database Search System is a powerful Federated search engine or Web portal that allows users to search many discrete Health sciences Ensembl is a joint scientific project between the European Bioinformatics Institute and the Wellcome Trust Sanger Institute, which was launched in 1999 in response to the imminent UniProt is the uni versal prot ein resource a central repository of Protein data created by combining Swiss-Prot, TrEMBL PubMed is a free search engine for accessing the MEDLINE database of citations and abstracts of biomedical research articles History See also History of genetics The existence of genes was first suggested by Gregor Mendel (1822-1884 who in the 1860s studied inheritance [1]
The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. The fibroblast growth factor receptors are as their name implies receptors which bind to members of the Fibroblast growth factor family of proteins FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. A marked difference between this gene product and the other family members is its lack of a cytoplasmic tyrosine kinase domain. The result is a transmembrane receptor that could interact with other family members and potentially inhibit signaling. Multiple alternatively spliced transcript variants encoding the same isoform have been found for this gene. [1]
References
Further reading
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. ". Gene 138 (1-2): 171–4. PMID 8125298.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. ". Gene 200 (1-2): 149–56. PMID 9373149.
- Wiedemann M, Trueb B (2001). "Characterization of a novel protein (FGFRL1) from human cartilage related to FGF receptors. ". Genomics 69 (2): 275–9. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 11031111.
- Kim I, Moon S, Yu K, et al. (2001). "A novel fibroblast growth factor receptor-5 preferentially expressed in the pancreas(1). ". Biochim. Biophys. Acta 1518 (1-2): 152–6. PMID 11267671.
- Sleeman M, Fraser J, McDonald M, et al. (2001). "Identification of a new fibroblast growth factor receptor, FGFR5. ". Gene 271 (2): 171–82. PMID 11418238.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. ". Proc. Natl. Acad. Sci. U. S. A. 99 (26): 16899–903. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 12477932.
- Trueb B, Zhuang L, Taeschler S, Wiedemann M (2003). "Characterization of FGFRL1, a novel fibroblast growth factor (FGF) receptor preferentially expressed in skeletal tissues. ". J. Biol. Chem. 278 (36): 33857–65. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 12813049.
- Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. ". Genome Res. 13 (10): 2265–70. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 12975309.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs. ". Nat. Genet. 36 (1): 40–5. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 14702039.
- Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites. ". Protein Sci. 13 (10): 2819–24. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 15340161.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). ". Genome Res. 14 (10B): 2121–7. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 15489334.
- Antoine M, Wirz W, Tag CG, et al. (2005). "Expression pattern of fibroblast growth factors (FGFs), their receptors and antagonists in primary endothelial cells and vascular smooth muscle cells. ". Growth Factors 23 (2): 87–95. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 16019430.
- Schild C, Trueb B (2006). "Aberrant expression of FGFRL1, a novel FGF receptor, in ovarian tumors. ". Int. J. Mol. Med. 16 (6): 1169–73. PMID 16273302.
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