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Fibroblast growth factor 6
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| Identifiers | ||
| Symbol(s) | FGF6; HBGF-6; HST2 | |
| External IDs | OMIM: 134921 MGI: 95520 HomoloGene: 10870 | |
| RNA expression pattern | ||
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| Orthologs | ||
| Human | Mouse | |
| Entrez | 2251 | 14177 |
| Ensembl | ENSG00000111241 | ENSMUSG00000000183 |
| Uniprot | P10767 | Q8C399 |
| Refseq | NM_020996 (mRNA) NP_066276 (protein) |
XM_001003439 (mRNA) XP_001003439 (protein) |
| Location | Chr 12: 4.41 - 4.43 Mb | Chr 6: 126.98 - 126.99 Mb |
| Pubmed search | [1] | [2] |
Fibroblast growth factor 6, also known as FGF6, is a human gene. The Human Genome Organisation (HUGO is an organization involved in the Human Genome Project, a project about mapping the human genome The Mouse Genome Informatics (MGI website is run by The Jackson Laboratory. HomoloGene, a tool of the National Center for Biotechnology Information (NCBI is a system for automated detection of homologs (similarity attributable to descent The Entrez Global Query Cross-Database Search System is a powerful Federated search engine or Web portal that allows users to search many discrete Health sciences Ensembl is a joint scientific project between the European Bioinformatics Institute and the Wellcome Trust Sanger Institute, which was launched in 1999 in response to the imminent UniProt is the uni versal prot ein resource a central repository of Protein data created by combining Swiss-Prot, TrEMBL PubMed is a free search engine for accessing the MEDLINE database of citations and abstracts of biomedical research articles History See also History of genetics The existence of genes was first suggested by Gregor Mendel (1822-1884 who in the 1860s studied inheritance [1]
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene displayed oncogenic transforming activity when transfected into mammalian cells. The mouse homolog of this gene exhibits a restricted expression profile predominantly in the myogenic lineage, which suggested a role in muscle regeneration or differentiation. [1]
References
Further reading
- Vainikka S, Partanen J, Bellosta P, et al. (1992). "Fibroblast growth factor receptor-4 shows novel features in genomic structure, ligand binding and signal transduction. ". EMBO J. 11 (12): 4273–80. PMID 1385111.
- Iida S, Yoshida T, Naito K, et al. (1992). "Human hst-2 (FGF-6) oncogene: cDNA cloning and characterization. ". Oncogene 7 (2): 303–9. PMID 1549352.
- Coulier F, Batoz M, Marics I, et al. (1991). "Putative structure of the FGF6 gene product and role of the signal peptide. ". Oncogene 6 (8): 1437–44. PMID 1886714.
- Marics I, Adelaide J, Raybaud F, et al. (1989). "Characterization of the HST-related FGF. 6 gene, a new member of the fibroblast growth factor gene family. ". Oncogene 4 (3): 335–40. PMID 2649847.
- Aerssens J, Chaffanet M, Baens M, et al. (1994). "Regional assignment of seven loci to 12p13. 2-pter by PCR analysis of somatic cell hybrids containing the der(12) or the der(X) chromosome from a mesothelioma showing t(X;12)(q22;p13). ". Genomics 20 (1): 119–21. PMID 8020938.
- Ornitz DM, Xu J, Colvin JS, et al. (1996). "Receptor specificity of the fibroblast growth factor family. ". J. Biol. Chem. 271 (25): 15292–7. PMID 8663044.
- Ropiquet F, Giri D, Kwabi-Addo B, et al. (2000). "Increased expression of fibroblast growth factor 6 in human prostatic intraepithelial neoplasia and prostate cancer. ". Cancer Res. 60 (15): 4245–50. PMID 10945637.
- Duplan SM, Théorêt Y, Kenigsberg RL (2002). "Antitumor activity of fibroblast growth factors (FGFs) for medulloblastoma may correlate with FGF receptor expression and tumor variant. ". Clin. Cancer Res. 8 (1): 246–57. PMID 11801566.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. ". Proc. Natl. Acad. Sci. U. S. A. 99 (26): 16899–903. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 12477932.
- Popovici C, Conchonaud F, Birnbaum D, Roubin R (2004). "Functional phylogeny relates LET-756 to fibroblast growth factor 9. ". J. Biol. Chem. 279 (38): 40146–52. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 15199049.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). ". Genome Res. 14 (10B): 2121–7. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 15489334.