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FYVE, RhoGEF and PH domain containing 4
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| Identifiers | ||
| Symbol(s) | FGD4; DKFZp313E1818; FRABIN; FRABP; MGC57222; ZFYVE6 | |
| External IDs | MGI: 2183747 HomoloGene: 26727 | |
| Orthologs | ||
| Human | Mouse | |
| Entrez | 121512 | 224014 |
| Ensembl | ENSG00000139132 | ENSMUSG00000022788 |
| Uniprot | Q96M96 | Q3UY56 |
| Refseq | NM_139241 (mRNA) NP_640334 (protein) |
NM_139232 (mRNA) NP_631978 (protein) |
| Location | Chr 12: 32.55 - 32.68 Mb | Chr 16: 16.34 - 16.51 Mb |
| Pubmed search | [1] | [2] |
FYVE, RhoGEF and PH domain containing 4, also known as FGD4, is a human gene. The Human Genome Organisation (HUGO is an organization involved in the Human Genome Project, a project about mapping the human genome The Mouse Genome Informatics (MGI website is run by The Jackson Laboratory. HomoloGene, a tool of the National Center for Biotechnology Information (NCBI is a system for automated detection of homologs (similarity attributable to descent The Entrez Global Query Cross-Database Search System is a powerful Federated search engine or Web portal that allows users to search many discrete Health sciences Ensembl is a joint scientific project between the European Bioinformatics Institute and the Wellcome Trust Sanger Institute, which was launched in 1999 in response to the imminent UniProt is the uni versal prot ein resource a central repository of Protein data created by combining Swiss-Prot, TrEMBL PubMed is a free search engine for accessing the MEDLINE database of citations and abstracts of biomedical research articles History See also History of genetics The existence of genes was first suggested by Gregor Mendel (1822-1884 who in the 1860s studied inheritance [1]
References
Further reading
- Obaishi H, Nakanishi H, Mandai K, et al. (1998). "Frabin, a novel FGD1-related actin filament-binding protein capable of changing cell shape and activating c-Jun N-terminal kinase. ". J. Biol. Chem. 273 (30): 18697–700. PMID 9668039.
- Ikeda W, Nakanishi H, Tanaka Y, et al. (2001). "Cooperation of Cdc42 small G protein-activating and actin filament-binding activities of frabin in microspike formation. ". Oncogene 20 (27): 3457–63. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 11429692.
- Ikeda W, Nakanishi H, Takekuni K, et al. (2001). "Identification of splicing variants of Frabin with partly different functions and tissue distribution. ". Biochem. Biophys. Res. Commun. 286 (5): 1066–72. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 11527409.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. ". Proc. Natl. Acad. Sci. U. S. A. 99 (26): 16899–903. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 12477932.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs. ". Nat. Genet. 36 (1): 40–5. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 14702039.
- Chen XM, Splinter PL, Tietz PS, et al. (2004). "Phosphatidylinositol 3-kinase and frabin mediate Cryptosporidium parvum cellular invasion via activation of Cdc42. ". J. Biol. Chem. 279 (30): 31671–8. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 15133042.
- De Sandre-Giovannoli A, Delague V, Hamadouche T, et al. (2006). "Homozygosity mapping of autosomal recessive demyelinating Charcot-Marie-Tooth neuropathy (CMT4H) to a novel locus on chromosome 12p11. 21-q13. 11. ". J. Med. Genet. 42 (3): 260–5. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 15744041.
- Delague V, Jacquier A, Hamadouche T, et al. (2007). "Mutations in FGD4 encoding the Rho GDP/GTP exchange factor FRABIN cause autosomal recessive Charcot-Marie-Tooth type 4H. ". Am. J. Hum. Genet. 81 (1): 1–16. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 17564959.
- Stendel C, Roos A, Deconinck T, et al. (2007). "Peripheral nerve demyelination caused by a mutant Rho GTPase guanine nucleotide exchange factor, frabin/FGD4. ". Am. J. Hum. Genet. 81 (1): 158–64. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 17564972.