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Fetuin B
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| Identifiers | ||
| Symbol(s) | FETUB; 16G2; Gugu; IRL685 | |
| External IDs | OMIM: 605954 MGI: 1890221 HomoloGene: 8660 | |
| RNA expression pattern | ||
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| Orthologs | ||
| Human | Mouse | |
| Entrez | 26998 | 59083 |
| Ensembl | ENSG00000090512 | ENSMUSG00000022871 |
| Uniprot | Q9UGM5 | Q6YJU1 |
| Refseq | NM_014375 (mRNA) NP_055190 (protein) |
NM_021564 (mRNA) NP_067539 (protein) |
| Location | Chr 3: 187.84 - 187.85 Mb | Chr 16: 22.84 - 22.86 Mb |
| Pubmed search | [1] | [2] |
Fetuin B, also known as FETUB, is a human gene. The Human Genome Organisation (HUGO is an organization involved in the Human Genome Project, a project about mapping the human genome The Mouse Genome Informatics (MGI website is run by The Jackson Laboratory. HomoloGene, a tool of the National Center for Biotechnology Information (NCBI is a system for automated detection of homologs (similarity attributable to descent The Entrez Global Query Cross-Database Search System is a powerful Federated search engine or Web portal that allows users to search many discrete Health sciences Ensembl is a joint scientific project between the European Bioinformatics Institute and the Wellcome Trust Sanger Institute, which was launched in 1999 in response to the imminent UniProt is the uni versal prot ein resource a central repository of Protein data created by combining Swiss-Prot, TrEMBL PubMed is a free search engine for accessing the MEDLINE database of citations and abstracts of biomedical research articles History See also History of genetics The existence of genes was first suggested by Gregor Mendel (1822-1884 who in the 1860s studied inheritance [1]
The protein encoded by this gene is a member of the fetuin family, part of the cystatin superfamily of cysteine protease inhibitors. Fetuins have been implicated in several diverse functions, including osteogenesis and bone resorption, regulation of the insulin and hepatocyte growth factor receptors, and response to systemic inflammation. This protein may be secreted by cells. [1]
References
Further reading
- Haidar M, Seddiki N, Gluckman JC, Gattegno L (1993). "Carbohydrate binding properties of the envelope glycoproteins of human immunodeficiency virus type 1. ". Glycoconj. J. 9 (6): 315–23. PMID 1284814.
- Hillier LD, Lennon G, Becker M, et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags. ". Genome Res. 6 (9): 807–28. PMID 8889549.
- Olivier E, Soury E, Ruminy P, et al. (2001). "Fetuin-B, a second member of the fetuin family in mammals. ". Biochem. J. 350 Pt 2: 589–97. PMID 10947975.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. ". Proc. Natl. Acad. Sci. U. S. A. 99 (26): 16899–903. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 12477932.
- Denecke B, Gräber S, Schäfer C, et al. (2003). "Tissue distribution and activity testing suggest a similar but not identical function of fetuin-B and fetuin-A. ". Biochem. J. 376 (Pt 1): 135–45. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 12943536.
- Wajih N, Borras T, Xue W, et al. (2004). "Processing and transport of matrix gamma-carboxyglutamic acid protein and bone morphogenetic protein-2 in cultured human vascular smooth muscle cells: evidence for an uptake mechanism for serum fetuin. ". J. Biol. Chem. 279 (41): 43052–60. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 15280384.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). ". Genome Res. 14 (10B): 2121–7. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 15489334.
- Hsu SJ, Nagase H, Balmain A (2005). "Identification of Fetuin-B as a member of a cystatin-like gene family on mouse chromosome 16 with tumor suppressor activity. ". Genome 47 (5): 931–46. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 15499407.
- Liu T, Qian WJ, Gritsenko MA, et al. (2006). "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. ". J. Proteome Res. 4 (6): 2070–80. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 16335952.
- Coen G, Ballanti P, Balducci A, et al. (2006). "Renal osteodystrophy: alpha-Heremans Schmid glycoprotein/fetuin-A, matrix GLA protein serum levels, and bone histomorphometry. ". Am. J. Kidney Dis. 48 (1): 106–13. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 16797392.
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