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F-box protein 5
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| Identifiers | ||
| Symbol(s) | FBXO5; EMI1; FBX5; Fbxo31 | |
| External IDs | OMIM: 606013 MGI: 1914391 HomoloGene: 8135 | |
| RNA expression pattern | ||
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| Orthologs | ||
| Human | Mouse | |
| Entrez | 26271 | 67141 |
| Ensembl | ENSG00000112029 | ENSMUSG00000019773 |
| Uniprot | Q9UKT4 | Q7TSG3 |
| Refseq | NM_012177 (mRNA) NP_036309 (protein) |
NM_025995 (mRNA) NP_080271 (protein) |
| Location | Chr 6: 153.33 - 153.35 Mb | Chr 10: 4.54 - 4.55 Mb |
| Pubmed search | [1] | [2] |
F-box protein 5, also known as FBXO5, is a human gene. The Human Genome Organisation (HUGO is an organization involved in the Human Genome Project, a project about mapping the human genome The Mouse Genome Informatics (MGI website is run by The Jackson Laboratory. HomoloGene, a tool of the National Center for Biotechnology Information (NCBI is a system for automated detection of homologs (similarity attributable to descent The Entrez Global Query Cross-Database Search System is a powerful Federated search engine or Web portal that allows users to search many discrete Health sciences Ensembl is a joint scientific project between the European Bioinformatics Institute and the Wellcome Trust Sanger Institute, which was launched in 1999 in response to the imminent UniProt is the uni versal prot ein resource a central repository of Protein data created by combining Swiss-Prot, TrEMBL PubMed is a free search engine for accessing the MEDLINE database of citations and abstracts of biomedical research articles History See also History of genetics The existence of genes was first suggested by Gregor Mendel (1822-1884 who in the 1860s studied inheritance [1]
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. This protein is similar to xenopus early mitotic inhibitor-1 (Emi1), which is a mitotic regulator that interacts with Cdc20 and inhibits the anaphase promoting complex. [1]
References
Further reading
- Gubin AN, Njoroge JM, Bouffard GG, Miller JL (1999). "Gene expression in proliferating human erythroid cells. ". Genomics 59 (2): 168-77. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 10409428.
- Cenciarelli C, Chiaur DS, Guardavaccaro D, et al. (1999). "Identification of a family of human F-box proteins. ". Curr. Biol. 9 (20): 1177-9. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 10531035.
- Winston JT, Koepp DM, Zhu C, et al. (1999). "A family of mammalian F-box proteins. ". Curr. Biol. 9 (20): 1180-2. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 10531037.
- Chiaur DS, Murthy S, Cenciarelli C, et al. (2000). "Five human genes encoding F-box proteins: chromosome mapping and analysis in human tumors. ". Cytogenet. Cell Genet. 88 (3-4): 255-8. PMID 10828603.
- Reimann JD, Freed E, Hsu JY, et al. (2001). "Emi1 is a mitotic regulator that interacts with Cdc20 and inhibits the anaphase promoting complex. ". Cell 105 (5): 645-55. PMID 11389834.
- Reimann JD, Jackson PK (2002). "Emi1 is required for cytostatic factor arrest in vertebrate eggs. ". Nature 416 (6883): 850-4. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 11976684.
- Hsu JY, Reimann JD, Sørensen CS, et al. (2002). "E2F-dependent accumulation of hEmi1 regulates S phase entry by inhibiting APC(Cdh1). ". Nat. Cell Biol. 4 (5): 358-66. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 11988738.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. ". Proc. Natl. Acad. Sci. U. S. A. 99 (26): 16899-903. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 12477932.
- Li Z, Hu CY, Mo BQ, et al. (2003). "[Effect of beta-carotene on gene expression of breast cancer cells]". Ai Zheng 22 (4): 380-4. PMID 12703993.
- Margottin-Goguet F, Hsu JY, Loktev A, et al. (2003). "Prophase destruction of Emi1 by the SCF(betaTrCP/Slimb) ubiquitin ligase activates the anaphase promoting complex to allow progression beyond prometaphase. ". Dev. Cell 4 (6): 813-26. PMID 12791267.
- Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6. ". Nature 425 (6960): 805-11. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 14574404.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs. ". Nat. Genet. 36 (1): 40-5. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 14702039.
- Moshe Y, Boulaire J, Pagano M, Hershko A (2004). "Role of Polo-like kinase in the degradation of early mitotic inhibitor 1, a regulator of the anaphase promoting complex/cyclosome. ". Proc. Natl. Acad. Sci. U. S. A. 101 (21): 7937-42. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 15148369.
- Hansen DV, Loktev AV, Ban KH, Jackson PK (2005). "Plk1 regulates activation of the anaphase promoting complex by phosphorylating and triggering SCFbetaTrCP-dependent destruction of the APC Inhibitor Emi1. ". Mol. Biol. Cell 15 (12): 5623-34. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 15469984.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). ". Genome Res. 14 (10B): 2121-7. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 15489334.
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network. ". Nature 437 (7062): 1173-8. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 16189514.
- Eldridge AG, Loktev AV, Hansen DV, et al. (2006). "The evi5 oncogene regulates cyclin accumulation by stabilizing the anaphase-promoting complex inhibitor emi1. ". Cell 124 (2): 367-80. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 16439210.
- Lehman NL, Verschuren EW, Hsu JY, et al. (2006). "Overexpression of the anaphase promoting complex/cyclosome inhibitor Emi1 leads to tetraploidy and genomic instability of p53-deficient cells. ". Cell Cycle 5 (14): 1569-73. PMID 16861914.
- Miller JJ, Summers MK, Hansen DV, et al. (2006). "Emi1 stably binds and inhibits the anaphase-promoting complex/cyclosome as a pseudosubstrate inhibitor. ". Genes Dev. 20 (17): 2410-20. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 16921029.
- Marangos P, Verschuren EW, Chen R, et al. (2007). "Prophase I arrest and progression to metaphase I in mouse oocytes are controlled by Emi1-dependent regulation of APC(Cdh1). ". J. Cell Biol. 176 (1): 65-75. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 17190794.
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