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Fibulin 1
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| Identifiers | ||
| Symbol(s) | FBLN1; FBLN | |
| External IDs | OMIM: 135820 MGI: 95487 HomoloGene: 21295 | |
| RNA expression pattern | ||
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| Orthologs | ||
| Human | Mouse | |
| Entrez | 2192 | 14114 |
| Ensembl | ENSG00000077942 | ENSMUSG00000006369 |
| Uniprot | P23142 | Q3TW70 |
| Refseq | NM_001996 (mRNA) NP_001987 (protein) |
NM_010180 (mRNA) NP_034310 (protein) |
| Location | Chr 22: 44.28 - 44.38 Mb | Chr 15: 85.03 - 85.11 Mb |
| Pubmed search | [1] | [2] |
Fibulin 1, also known as FBLN1, is a human gene. The Human Genome Organisation (HUGO is an organization involved in the Human Genome Project, a project about mapping the human genome The Mouse Genome Informatics (MGI website is run by The Jackson Laboratory. HomoloGene, a tool of the National Center for Biotechnology Information (NCBI is a system for automated detection of homologs (similarity attributable to descent The Entrez Global Query Cross-Database Search System is a powerful Federated search engine or Web portal that allows users to search many discrete Health sciences Ensembl is a joint scientific project between the European Bioinformatics Institute and the Wellcome Trust Sanger Institute, which was launched in 1999 in response to the imminent UniProt is the uni versal prot ein resource a central repository of Protein data created by combining Swiss-Prot, TrEMBL PubMed is a free search engine for accessing the MEDLINE database of citations and abstracts of biomedical research articles History See also History of genetics The existence of genes was first suggested by Gregor Mendel (1822-1884 who in the 1860s studied inheritance
Fibulin 1 is a secreted glycoprotein that becomes incorporated into a fibrillar extracellular matrix. Calcium-binding is apparently required to mediate its binding to laminin and nidogen. It mediates platelet adhesion via binding fibrinogen. Four splice variants which differ in the 3' end have been identified. Each variant encodes a different isoform, but no functional distinctions have been identified among the four variants. [1]
References
Further reading
- Balbona K, Tran H, Godyna S, et al. (1992). "Fibulin binds to itself and to the carboxyl-terminal heparin-binding region of fibronectin. ". J. Biol. Chem. 267 (28): 20120-5. PMID 1400330.
- Argraves WS, Tran H, Burgess WH, Dickerson K (1991). "Fibulin is an extracellular matrix and plasma glycoprotein with repeated domain structure. ". J. Cell Biol. 111 (6 Pt 2): 3155-64. PMID 2269669.
- Argraves WS, Dickerson K, Burgess WH, Ruoslahti E (1989). "Fibulin, a novel protein that interacts with the fibronectin receptor beta subunit cytoplasmic domain. ". Cell 58 (4): 623-9. PMID 2527614.
- Sasaki T, Göhring W, Pan TC, et al. (1996). "Binding of mouse and human fibulin-2 to extracellular matrix ligands. ". J. Mol. Biol. 254 (5): 892-9. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 7500359.
- Roark EF, Keene DR, Haudenschild CC, et al. (1995). "The association of human fibulin-1 with elastic fibers: an immunohistological, ultrastructural, and RNA study. ". J. Histochem. Cytochem. 43 (4): 401-11. PMID 7534784.
- Tran H, Tanaka A, Litvinovich SV, et al. (1995). "The interaction of fibulin-1 with fibrinogen. A potential role in hemostasis and thrombosis. ". J. Biol. Chem. 270 (33): 19458-64. PMID 7642629.
- Mattei MG, Pan TC, Zhang RZ, et al. (1995). "The fibulin-1 gene (FBLN1) is located on human chromosome 22 and on mouse chromosome 15. ". Genomics 22 (2): 437-8. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 7806231.
- Korenberg JR, Chen XN, Tran H, Argraves WS (1995). "Localization of the human gene for fibulin-1 (FBLN1) to chromosome band 22q13. 3. ". Cytogenet. Cell Genet. 68 (3-4): 192-3. PMID 7842734.
- Brown JC, Wiedemann H, Timpl R (1994). "Protein binding and cell adhesion properties of two laminin isoforms (AmB1eB2e, AmB1sB2e) from human placenta. ". J. Cell. Sci. 107 ( Pt 1): 329-38. PMID 8175920.
- Pan TC, Kluge M, Zhang RZ, et al. (1993). "Sequence of extracellular mouse protein BM-90/fibulin and its calcium-dependent binding to other basement-membrane ligands. ". Eur. J. Biochem. 215 (3): 733-40. PMID 8354280.
- Clinton GM, Rougeot C, Derancourt J, et al. (1996). "Estrogens increase the expression of fibulin-1, an extracellular matrix protein secreted by human ovarian cancer cells. ". Proc. Natl. Acad. Sci. U. S. A. 93 (1): 316-20. PMID 8552629.
- Miosge N, Götz W, Sasaki T, et al. (1996). "The extracellular matrix proteins fibulin-1 and fibulin-2 in the early human embryo. ". Histochem. J. 28 (2): 109-16. PMID 8737292.
- Godyna S, Diaz-Ricart M, Argraves WS (1996). "Fibulin-1 mediates platelet adhesion via a bridge of fibrinogen. ". Blood 88 (7): 2569-77. PMID 8839849.
- Tran H, Mattei M, Godyna S, Argraves WS (1997). "Human fibulin-1D: molecular cloning, expression and similarity with S1-5 protein, a new member of the fibulin gene family. ". Matrix Biol. 15 (7): 479-93. PMID 9106159.
- Tran H, VanDusen WJ, Argraves WS (1997). "The self-association and fibronectin-binding sites of fibulin-1 map to calcium-binding epidermal growth factor-like domains. ". J. Biol. Chem. 272 (36): 22600-6. PMID 9278415.
- Adam S, Göhring W, Wiedemann H, et al. (1997). "Binding of fibulin-1 to nidogen depends on its C-terminal globular domain and a specific array of calcium-binding epidermal growth factor-like (EG) modules. ". J. Mol. Biol. 272 (2): 226-36. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 9299350.
- Qing J, Maher VM, Tran H, et al. (1997). "Suppression of anchorage-independent growth and matrigel invasion and delayed tumor formation by elevated expression of fibulin-1D in human fibrosarcoma-derived cell lines. ". Oncogene 15 (18): 2159-68. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 9393974.
- Hayashido Y, Lucas A, Rougeot C, et al. (1998). "Estradiol and fibulin-1 inhibit motility of human ovarian- and breast-cancer cells induced by fibronectin. ". Int. J. Cancer 75 (4): 654-8. PMID 9466671.
- Roger P, Pujol P, Lucas A, et al. (1998). "Increased immunostaining of fibulin-1, an estrogen-regulated protein in the stroma of human ovarian epithelial tumors. ". Am. J. Pathol. 153 (5): 1579-88. PMID 9811350.
- Perbal B, Martinerie C, Sainson R, et al. (1999). "The C-terminal domain of the regulatory protein NOVH is sufficient to promote interaction with fibulin 1C: a clue for a role of NOVH in cell-adhesion signaling. ". Proc. Natl. Acad. Sci. U. S. A. 96 (3): 869-74. PMID 9927660.
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