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Epoprostenol
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| Systematic (IUPAC) name | |
| (5Z)-5-[(3aR,4R,5R,6aS)-5-hydroxy-4- [(E,3S)-3-hydroxyoct-1-enyl]-3,3a,4,5,6,6a- hexahydrocyclopenta[d]furan-2-ylidene]pentanoic acid |
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| Identifiers | |
| CAS number | |
| ATC code | B01 |
| PubChem | |
| DrugBank | |
| Chemical data | |
| Formula | C20H32O5 |
| Mol. mass | 352. IUPAC Nomenclature is a system of naming Chemical compounds and of describing the science of Chemistry in general CAS registry numbers are unique numerical identifiers for Chemical compounds Polymers biological sequences mixtures and Alloys They are also referred to The Anatomical Therapeutic Chemical Classification System is used for the classification of drugs It is controlled by the WHO Collaborating Centre for Drug A section of the Anatomical Therapeutic Chemical Classification System. PubChem is a Database of chemical Molecules The system is maintained by the National Center for Biotechnology Information (NCBI a component The DrugBank database available at the University of Alberta is a unique Bioinformatics and Cheminformatics resource that combines detailed drug (i A chemical formula is a way of expressing information about the Atoms that constitute a particular Chemical compound, and how the relationship between those atoms changes Carbon (kɑɹbən is a Chemical element with the symbol C and its Atomic number is 6 Hydrogen (ˈhaɪdrədʒən is the Chemical element with Atomic number 1 Oxygen (from the Greek roots ὀξύς (oxys (acid literally "sharp" from the taste of acids and -γενής (-genēs (producer literally begetteris the The molecular mass (abbreviated m of a substance, more commonly referred to as molecular weight and abbreviated as MW, is the Mass of one 465 g/mol |
| SMILES | & |
| Pharmacokinetic data | |
| Bioavailability | Not applicable (IV only) |
| Metabolism | To 6-keto-PGF1α and 6,15-diketo-13,14-dihydro-PGF1α |
| Half life | 6 minutes (in vitro) |
| Excretion | Renal |
| Therapeutic considerations | |
| Licence data |
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| Pregnancy cat. |
B(US) |
| Legal status |
℞ Prescription only |
| Routes | Intravenous |
Epoprostenol is a synthetic form of prostacyclin, and is used to treat pulmonary hypertension. In Pharmacology, bioavailability is used to describe the fraction of an administered Dose of unchanged drug that reaches the Systemic circulation, one of Drug metabolism is the Metabolism of drugs, their Biochemical modification or degradation usually through specialized enzymatic systems The biological half-life of a substance is the time it takes for a substance (drug radioactive nuclide or other to lose half of its pharmacologic physiologic or radiologic activity In vitro ( Latin: within the glass refers to the technique of performing a given experiment in a controlled environment outside of a living Organism Excretion is the process of eliminating waste products of Metabolism and other non-useful materials The kidneys are complicated organs that have numerous biological roles The regulation of therapeutic goods, that is drugs and therapeutic devices, varies by jurisdiction The pregnancy category of a pharmaceutical agent is an assessment of the risk of fetal injury due to the pharmaceutical if it is used as directed by the mother during The United States of America —commonly referred to as the The regulation of therapeutic goods, that is drugs and therapeutic devices, varies by jurisdiction In Pharmacology and Toxicology, a route Intravenous therapy or IV therapy is the giving of Liquid substances directly into a Vein. Prostacyclin (or PGI2) is a member of the family of Lipid Molecules known as Eicosanoids. In Medicine, pulmonary hypertension (PH is an increase in blood pressure in the Pulmonary artery, Pulmonary vein, or pulmonary capillaries together known It is sold under the trade name Flolan. A trade name, also known as a trading name or a business name, is the name which a Business trades under for commercial purposes although its registered
Contents |
Clinical pharmacology
As an analogue of prostacyclin PGI2, epoprostenol effects vasodilation, which in turn lowers the blood pressure. Blood pressure is also the title of a short story by Damon Runyan in Guys and Dolls and Other Stories Epoprotstenol also inhibits platelet aggregation, though the role this phenomenon may play in relation to pulmonary hypertension has yet to be determined. Platelets, or Thrombocytes, are small cytoplasmic bodies derived from cells They circulate in the Blood of Mammals and are involved
Administration
Epoprostenol is given via continuous infusion that requires a semi-permanent central venous catheter. In Medicine, a central venous catheter ( CVC or central venous line or central venous access catheter) is a Catheter placed into a This means that the patient must be attached to an infusion pump at all times. An infusion pump infuses fluids Medication or Nutrients into a patient's Circulatory system. This delivery system can cause sepsis and thrombosis. Sepsis is a serious medical condition characterized by a whole-body inflammatory state (called a Systemic inflammatory response syndrome or SIRS caused Thrombosis is the formation of a blood Clot ( Thrombus) inside a Blood vessel, obstructing the flow of Blood through the Circulatory Because epoprostenol is unstable, it must be kept cold, even during administration. Since it has a half-life of 3 to 5 minutes, the infusion has to be continuous (24/7), and an interruption can lead to a potentially fatal rebound of symptoms. Rebound effect is the tendency of a Medication to when discontinued to cause a return of the Symptoms being treated more severe than before
History
Epoprostenol was developed by GlaxoSmithKline and approved in the USA as a medicine in 1995. GlaxoSmithKline plc () is a United Kingdom -based pharmaceutical, biological and Healthcare Company. The United States of America —commonly referred to as the Year 1995 ( MCMXCV) was a Common year starting on Sunday. Events of 1995
Marketing
It was licensed to Myogen, which was subsequently acquired by Gilead Sciences. Gilead Sciences is a Biopharmaceutical company that discovers develops and commercializes Therapeutics to advance the care of patients suffering from life-threatening Flolan is marketed in the United States by Gilead Sciences and elsewhere by GlaxoSmithKline.
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