The Entrez logo
The Entrez Global Query Cross-Database Search System is a powerful federated search engine, or web portal that allows users to search many discrete health sciences databases at the National Center for Biotechnology Information (NCBI) website. Federated search is the simultaneous search of multiple online databases and is an emerging feature of automated Web-based Library and Information retrieval A web portal is a site that provides a single function via a web page or site Health science is the applied science dealing with Health, and it includes many sub disciplines The National Center for Biotechnology Information ( NCBI) is part of the United States National Library of Medicine (NLM a branch of the National Institutes NCBI is part of the National Library of Medicine (NLM), itself a department of the National Institutes of Health (NIH) of the United States government. The United States National Library of Medicine ( NLM) operated by the United States federal government, is the world's largest Medical library. "NIH" redirects here For other meanings of NIH see NIH (disambiguation. The federal government of the United States is the central United States Governmental body established by the United States Constitution. Entrez also happens to be the French second person plural (or formal) form of the verb "to enter", meaning literally "come in".
Entrez Global Query is an integrated search and retrieval system that provides access to all databases simultaneously with a single query string and user interface. Entrez can efficiently retrieve related sequences, structures, and references. In Biochemistry, the primary structure of a biological molecule is the exact specification of its atomic composition and the chemical bonds connecting those atoms (including In Biochemistry and Chemistry, the tertiary structure of a Protein or any other Macromolecule is its three-dimensional structure as defined The Entrez system can provide views of gene and protein sequences and chromosome maps. History See also History of genetics The existence of genes was first suggested by Gregor Mendel (1822-1884 who in the 1860s studied inheritance Proteins are large Organic compounds made of Amino acids arranged in a linear chain and joined together by Peptide bonds between the Carboxyl A chromosome is an organized structure of DNA and Protein that is found in cells. Some textbooks are also available online through the Entrez system.
Features
The Entrez front page provides, by default, access to the global query. All databases indexed by Entrez can be searched via a single query string, supporting boolean operators and search term tags to limit parts of the search statement to particular fields. This returns a unified results page, that shows the number of hits for the search in each of the databases, which are also links to actual search results for that particular database.
Entrez also provides a similar interface for searching each particular database and for refining search results. The Limits feature allows the user to narrow a search a web forms interface. The History feature gives a numbered list of recently performed queries. Results of previous queries can be referred to by number and combined via boolean operators. Search results can be saved temporarily in a Clipboard. Users with a MyNCBI account can save queries indefinitely and also choose to have updates with new search results e-mailed for saved queries of most databases. It is widely used in the field of biotechnology to enhance the knowledge of students worldwide.
Databases
Entrez searches the following databases:
- PubMed: biomedical literature citations and abstracts, including Medline - articles from (mainly medical) journals, often including abstracts. PubMed is a free search engine for accessing the MEDLINE database of citations and abstracts of biomedical research articles MEDLINE ( Medical Literature Analysis and Retrieval System Online is a literature database of life sciences and biomedical information A medical journal is a Scientific journal devoted to the field of Medicine. For a broader class of publications which include scientific journals see Academic journal. Links to PubMed Central and other full-text resources are provided to articles from the 1990s. PubMed Central is a free digital database of full-text Scientific literature in biomedical and life sciences The 1990s collectively refers to the years between and including 1990 and 1999
- PubMed Central: free, full text journal articles
- Site Search: NCBI web and FTP web sites
- Books: online books
- OMIM: online Mendelian Inheritance in Man
- OMIA: online Mendelian Inheritance in Animals
- Nucleotide: sequence database (GenBank)
- Protein: sequence database
- Genome: whole genome sequences and Mapping
- Structure: three-dimensional macromolecular structures
- Taxonomy: organisms in GenBank Taxonomy
- SNP: single nucleotide polymorphism
- Gene: gene-centered information
- HomoloGene: eukaryotic homology groups
- PubChem Compound: unique small molecule chemical structures
- PubChem Substance: deposited chemical substance records
- Genome Project: genome project information
- UniGene: gene-oriented clusters of transcript sequences
- CDD: conserved protein domain database
- 3D Domains: domains from Entrez Structure
- UniSTS: markers and mapping data
- PopSet: population study data sets (epidemiology)
- GEO Profiles: expression and molecular abundance profiles
- GEO DataSets: experimental sets of GEO data
- Cancer Chromosomes: cytogenetic databases
- PubChem BioAssay: bioactivity screens of chemical substances
- GENSAT: gene expression atlas of mouse central nervous system
- Probe: sequence-specific reagents
- NLM Catalog: NLM bibliographic data for over 1. PubMed Central is a free digital database of full-text Scientific literature in biomedical and life sciences The Mendelian Inheritance in Man project is a Database that catalogues all the known Diseases with a genetic component, and—when possible—links them Mendelian inheritance (or Mendelian genetics or Mendelism) is a set of primary tenets relating to the transmission of hereditary characteristics from parent Online Mendelian Inheritance in Animals (OMIA is an Online database of Genes, inherited disorders and traits in more than 135 animal species The GenBank Sequence database is an Open access, annotated collection of all publicly available Nucleotide sequences and their Protein translations The Human Genome Project (HGP was an international Scientific research project with a primary goal to determine the sequence of chemical base pairs which make up DNA Linnaean taxonomy is a method of classifying living things originally devised by (and named for Carolus Linnaeus, although it has changed considerably since his time PubChem is a Database of chemical Molecules The system is maintained by the National Center for Biotechnology Information (NCBI a component PubChem is a Database of chemical Molecules The system is maintained by the National Center for Biotechnology Information (NCBI a component Genome projects are Scientific endeavours that ultimately aim to determine the complete Genome sequence of an Organism (be it an Animal, a UniGene is an NCBI database of the Transcriptome and thus despite the name not primarily a database for Genes. Epidemiology is the study of factors affecting the Health and Illness of populations and serves as the foundation and Logic of interventions made in the 2 million journals, books, audiovisuals, computer software, electronic resources, and other materials resident in LocatorPlus (updated every weekday).
Accessing Entrez
In addition to using the search engine forms to query the data in Entrez, NCBI provides the Entrez Programming Utilities (eUtils) for more direct access to query results. The eUtils are accessed by posting specially formed URLs to the NCBI server, and parsing the XML response. There is also an eUtils SOAP interface. SOAP (see below for name and origins is a protocol for exchanging XML -based messages over Computer networks normally using
See also
External links
The Bioinformatic-Harvester is a bioinformatic meta Search engine at KIT Karlsruhe Institute of Technology for Genes and protein-associated information In Bioinformatics, B asic L ocal A lignment S earch T ool or BLAST, is an Algorithm for comparing primary Ensembl is a joint scientific project between the European Bioinformatics Institute and the Wellcome Trust Sanger Institute, which was launched in 1999 in response to the imminent FlyBase is an online Bioinformatics Database of the biology and genome of the Model organism Drosophila melanogaster and related Drosophilid The GFP-cDNA project documents the localisation of Proteins to subcellular compartments of the Eukaryotic cell applying Fluorescence microscopy Biological databases are libraries of life sciences information collected from scientific experiments published literature high throughput experiment technology and computational analyses Google Scholar ( GS) is a freely-accessible Web search engine that indexes the full text of Scholarly literature across an array of publishing formats GoPubMed is a knowledge-based search engine for biomedical texts HomoloGene, a tool of the National Center for Biotechnology Information (NCBI is a system for automated detection of homologs (similarity attributable to descent Information Hyperlinked over Proteins (or iHOP) is an online service that provides a gene-guided network to access PubMed abstracts The Mendelian Inheritance in Man project is a Database that catalogues all the known Diseases with a genetic component, and—when possible—links them MitoCheck is an integrated research project which brings together leading European research groups to study systematically the regulation of Mitosis in Human PSORT is a Bioinformatics tool available online at http//psort UniProt is the uni versal prot ein resource a central repository of Protein data created by combining Swiss-Prot, TrEMBL SOSUI is a free online tool that predicts a part of the Secondary structure of proteins from a given Amino acid sequence (AAS "Sciencenet" is an experimental search engine at KIT ( Karlsruhe Institute of Technology - Liebel-Lab for scientific knowledge The Zebrafish Information Network ( ZFIN is an online Biological database of information about the Zebrafish ( Danio rerio)
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