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Embutramide
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| Systematic (IUPAC) name | |
| N-[2-ethyl-2-(3-methoxyphenyl)butyl]-4-hydroxybutanamide | |
| Identifiers | |
| CAS number | |
| ATC code | ? |
| PubChem | |
| Chemical data | |
| Formula | C17H27NO3 |
| Mol. mass | 293. IUPAC Nomenclature is a system of naming Chemical compounds and of describing the science of Chemistry in general CAS registry numbers are unique numerical identifiers for Chemical compounds Polymers biological sequences mixtures and Alloys They are also referred to The Anatomical Therapeutic Chemical Classification System is used for the classification of drugs It is controlled by the WHO Collaborating Centre for Drug PubChem is a Database of chemical Molecules The system is maintained by the National Center for Biotechnology Information (NCBI a component A chemical formula is a way of expressing information about the Atoms that constitute a particular Chemical compound, and how the relationship between those atoms changes Carbon (kɑɹbən is a Chemical element with the symbol C and its Atomic number is 6 Hydrogen (ˈhaɪdrədʒən is the Chemical element with Atomic number 1 Nitrogen (ˈnaɪtɹəʤɪn is a Chemical element that has the symbol N and Atomic number 7 and Atomic weight 14 Oxygen (from the Greek roots ὀξύς (oxys (acid literally "sharp" from the taste of acids and -γενής (-genēs (producer literally begetteris the The molecular mass (abbreviated m of a substance, more commonly referred to as molecular weight and abbreviated as MW, is the Mass of one 401 g/mol |
| Pharmacokinetic data | |
| Bioavailability | ? |
| Metabolism | ? |
| Half life | ? |
| Excretion | ? |
| Therapeutic considerations | |
| Pregnancy cat. |
? |
| Legal status | |
| Routes | intravenous |
Embutramide (Embutane) is a potent sedative drug. In Pharmacology, bioavailability is used to describe the fraction of an administered Dose of unchanged drug that reaches the Systemic circulation, one of Drug metabolism is the Metabolism of drugs, their Biochemical modification or degradation usually through specialized enzymatic systems The biological half-life of a substance is the time it takes for a substance (drug radioactive nuclide or other to lose half of its pharmacologic physiologic or radiologic activity Excretion is the process of eliminating waste products of Metabolism and other non-useful materials The pregnancy category of a pharmaceutical agent is an assessment of the risk of fetal injury due to the pharmaceutical if it is used as directed by the mother during The regulation of therapeutic goods, that is drugs and therapeutic devices, varies by jurisdiction The Controlled Substances Act ( CSA) was enacted into law by the Congress of the United States as Title II of the Comprehensive Drug Abuse Prevention and Control The United States of America —commonly referred to as the In Pharmacology and Toxicology, a route A sedative, or more specifically a sedative-hypnotic, is a substance that depresses the Central nervous system (CNS resulting in calmness relaxation sleepiness It was developed as a general anaesthetic agent, but was found to have a very narrow therapeutic window, with a 50mg/kg dose producing effective sedation, but a 75mg/kg dose was fatal. A general anaesthetic (or anesthetic, see Spelling differences) drug is an anaesthetic drug that brings about a reversible loss of Consciousness. Along with strong sedative effects, embutramide also produces respiratory depression and ventricular arrythmia. In Medicine, hypoventilation (also known as respiratory depression) occurs when ventilation is inadequate ( hypo means "below" to perform needed Dysrhythmia redirects here For the American band see Dysrhythmia (band. This meant that it has never been adopted for medical use as an anaesthetic as it is far too dangerous for this purpose, but instead is used for euthanasia in veterinary medicine, mainly for euthanising dogs. Put to sleep redirects here For its literal meaning see Sleep or Anaesthetic. Veterinary medicine the application of medical, diagnostic, and therapeutic principles to companion, domestic, exotic, wildlife It is formulated as a combination product under the brand name Tributame, which also contains chloroquine and lidocaine. Chloroquine is a 4-aminoquinoline drug used in the treatment or prevention of Malaria. Lidocaine ( INN) (ˈlaɪdoʊkeɪn or lignocaine (former BAN) (/ˈlɪgnoʊkeɪn/ is a common Local anesthetic and antiarrhythmic drug [1]
Embutamide is used for euthanasia of a range of different animals, mainly small animals kept as pets rather than large farm animals. It may cause significant pain to the animal being euthanised,[1] and so may be less humane than older drugs used for this purpose such as pentobarbital, however it may have less abuse potential than barbiturates especially in the Tributame combination formulation, and so is less likely to be diverted for recreational abuse. Pentobarbital is a short-acting Barbiturate that is available as both a Free acid and a Sodium salt, the former of which is only slightly soluble in water [2] Embutramide has however been reported to be used for suicide by people with access to the drug,[2][3] and was added to the list of Schedule III drugs in the USA in 2006. This is a list of Schedule III drugs under the Controlled Substances Act for the United States. [4]
References
- ^ Hellebrekers LJ, Baumans V, Bertens AP, Hartman W. The use of T61 for the humane killing of pets and laboratory animals. Tijdschrift voor Diergeneeskdunde. (Dutch) 1990 Jul 1;115(13):625-32.
- ^ Smith RA, Lewis D. Suicide by ingestion of T-61. Veterinary and Human Toxicology. 1989 Aug;31(4):319-20.
- ^ Kintz P, Cirimele V, Ludes B. Blood investigation in a fatality involving the veterinary drug T-61. Journal of Analytical Toxicology. 2002 Oct;26(7):529-31.
- ^ DEA lists embutramide as schedule III controlled substance. Journal of the American Veterinary Medical Association. 2006 Nov 1;229(9):1358.
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