Elongation factor 2 kinase

In enzymology, an elongation factor 2 kinase (EC 2.7.11.20) is an enzyme that catalyzes the chemical reaction

ATP + [elongation factor 2] $\rightleftharpoons$ ADP + [elongation factor 2] phosphate

Thus, the two substrates of this enzyme are ATP and [[[elongation factor 2]]], whereas its two products are ADP and [[[elongation factor 2] phosphate]]. Enzymes are Biomolecules that catalyze ( ie increase the rates of Chemical reactions Almost all enzymes are Proteins This article is about the Enzyme Commission codes For the European Commission system for coding chemicals see EC-No. Enzymes are Biomolecules that catalyze ( ie increase the rates of Chemical reactions Almost all enzymes are Proteins Catalysis is the process in which the rate of a Chemical reaction is increased by means of a Chemical substance known as a catalyst A chemical reaction is a process that always results in the interconversion of Chemical substances The substance or substances initially involved in a chemical reaction are called Adenosine-5'-triphosphate ( ATP) is a multifunctional Nucleotide that is most important as a " molecular currency" of intracellular Energy A product is a substance that forms as a result of a Biological - or Chemical reaction. Adenosine diphosphate, abbreviated ADP, is a Nucleotide. It is an Ester of Pyrophosphoric acid with the Nucleoside Adenosine

This enzyme belongs to the family of transferases, specifically those transferring a phosphate group to the sidechain oxygen atom of serine or threonine residues in proteins (protein-serine/threonine kinases). In Biochemistry, a transferase is an Enzyme that catalyzes the transfer of a Functional group (e Oxygen (from the Greek roots ὀξύς (oxys (acid literally "sharp" from the taste of acids and -γενής (-genēs (producer literally begetteris the Serine (abbreviated as Ser or S) is an Organic compound with the formula H[[oxygen O]]2 CCH NH sub>2CH2OH Threonine (abbreviated as Thr or T) is an α- Amino acid with the Chemical formula HO2CCH(NH2CH(OHCH3 Proteins are large Organic compounds made of Amino acids arranged in a linear chain and joined together by Peptide bonds between the Carboxyl Serine/threonine Protein kinases ( phosphorylate the OH group of Serine or Threonine (which have similar sidechains The systematic name of this enzyme class is ATP:[elongation factor 2] phosphotransferase. Other names in common use include Ca/CaM-kinase III, calmodulin-dependent protein kinase III, CaM kinase III, eEF2 kinase, eEF2K, EF2K, and STK19.

References

IUBMB entry for 2.7.11.20
BRENDA references for 2.7.11.20 (Recommended. )
PubMed references for 2.7.11.20
PubMed Central references for 2.7.11.20
Google Scholar references for 2.7.11.20
Mitsui K, Brady M, Palfrey HC, Nairn AC (1993). "Purification and characterization of calmodulin-dependent protein kinase III from rabbit reticulocytes and rat pancreas". J. Biol. Chem. 268: 13422–33. PMID 8514778.
Hincke MT, Nairn AC (Pt 3). "Phosphorylation of elongation factor 2 during Ca(2+)-mediated secretion from rat parotid acini". Biochem. J. 282: 877–82. PMID 1372803.
Knebel A, Morrice N, Cohen P (2001). "A novel method to identify protein kinase substrates: eEF2 kinase is phosphorylated and inhibited by SAPK4/p38delta". EMBO. J. 20: 4360–9. doi:10.1093/emboj/20.16.4360. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 11500363.
Sans MD, Xie Q, Williams JA (2004). "Regulation of translation elongation and phosphorylation of eEF2 in rat pancreatic acini". Biochem. Biophys. Res. Commun. 319: 144–51. doi:10.1016/j.bbrc.2004.04.164. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 15158453.
Browne GJ, Finn SG, Proud CG (2004). "Stimulation of the AMP-activated protein kinase leads to activation of eukaryotic elongation factor 2 kinase and to its phosphorylation at a novel site, serine 398". J. Biol. Chem. 279: 12220–31. doi:10.1074/jbc.M309773200. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 14709557.
Ryazanov AG (2002). "Elongation factor-2 kinase and its newly discovered relatives". FEBS. Lett. 514: 26–9. doi:10.1016/S0014-5793(02)02299-8. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 11904175.

External links

IUBMB entry for 2.7.11.20

KEGG entry for 2.7.11.20

BRENDA entry for 2.7.11.20

NiceZyme view of 2.7.11.20

EC2PDB: PDB structures for 2.7.11.20

PRIAM entry for 2.7.11.20

PUMA2 entry for 2.7.11.20

IntEnz: Integrated Enzyme entry for 2.7.11.20

MetaCyc entry for 2.7.11.20

Gene Ontology (GO) codes

EGO entry for GO code 0004686: eukaryotic elongation factor-2 kinase

AMIGO entry for GO code 0004686: eukaryotic elongation factor-2 kinase

Medical Subject Headings ( MeSH) is a huge Controlled vocabulary (or metadata system for the purpose of indexing journal articles and books

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