| Ebselen | |
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| IUPAC name | 2-Phenyl-1,2-benzoselenazol-3-one |
| Identifiers | |
| CAS number | [60940-34-3] |
| PubChem | |
| SMILES | C1=CC=C(C=C1)N2C(=O)C3=CC=CC=C3[Se]2 |
| Properties | |
| Molecular formula | C13H9NOSe |
| Molar mass | 274. IUPAC Nomenclature is a system of naming Chemical compounds and of describing the science of Chemistry in general CAS registry numbers are unique numerical identifiers for Chemical compounds Polymers biological sequences mixtures and Alloys They are also referred to PubChem is a Database of chemical Molecules The system is maintained by the National Center for Biotechnology Information (NCBI a component A chemical formula is a way of expressing information about the Atoms that constitute a particular Chemical compound, and how the relationship between those atoms changes Molar mass, symbol M, is the Mass of one mole of a substance ( Chemical element or Chemical compound) 17666 |
| Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) Infobox disclaimer and references |
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Ebselen or 2-phenyl-1, 2-benzisoselenazol-3(2H)-one (also called PZ 51 or DR3305), is a mimic of glutathione peroxidase and can also react with peroxynitrite. In Chemistry, the standard state of a material is its state at 1 bar (100 Kilopascals exactly Glutathione peroxidase () is the general name of an Enzyme family with Peroxidase activity whose main biological role is to protect the organism from oxidative damage Peroxynitrite is the Anion with the formula ONOO− It is an unstable "valence isomer" of Nitrate, NO3− which has the [1] It is being investigated as a possible treatment for reperfusion injury and stroke. Reperfusion injury refers to damage to tissue caused when Blood supply returns to the tissue after a period of Ischemia. A stroke is the rapidly developing loss of brain functions due to a disturbance in the blood vessels supplying blood to the brain [2][3]
References
- ^ Schewe T (1995). "Molecular actions of ebselen--an antiinflammatory antioxidant". Gen Pharmacol 26 (6): 1153–69. PMID 7590103.
- ^ Parnham M, Sies H (2000). "Ebselen: prospective therapy for cerebral ischaemia". Expert Opin Investig Drugs 9 (3): 607–19. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 11060699.
- ^ Yamaguchi T, Sano K, Takakura K, Saito I, Shinohara Y, Asano T, Yasuhara H (1998). "Ebselen in acute ischemic stroke: a placebo-controlled, double-blind clinical trial. Ebselen Study Group". Stroke 29 (1): 12–7. PMID 9445321.
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