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Exocyst complex component 5
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| Identifiers | ||
| Symbol(s) | EXOC5; DKFZp666H126; HSEC10; PRO1912; SEC10; SEC10L1; SEC10P | |
| External IDs | OMIM: 604469 MGI: 2145645 HomoloGene: 38195 | |
| RNA expression pattern | ||
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| Orthologs | ||
| Human | Mouse | |
| Entrez | 10640 | 105504 |
| Ensembl | ENSG00000070367 | ENSMUSG00000061244 |
| Uniprot | O00471 | Q3U8A5 |
| Refseq | NM_006544 (mRNA) NP_006535 (protein) |
XM_993269 (mRNA) XP_998363 (protein) |
| Location | Chr 14: 56.74 - 56.81 Mb | Chr 14: 47.93 - 47.99 Mb |
| Pubmed search | [1] | [2] |
Exocyst complex component 5, also known as EXOC5, is a human gene. The Human Genome Organisation (HUGO is an organization involved in the Human Genome Project, a project about mapping the human genome The Mouse Genome Informatics (MGI website is run by The Jackson Laboratory. HomoloGene, a tool of the National Center for Biotechnology Information (NCBI is a system for automated detection of homologs (similarity attributable to descent The Entrez Global Query Cross-Database Search System is a powerful Federated search engine or Web portal that allows users to search many discrete Health sciences Ensembl is a joint scientific project between the European Bioinformatics Institute and the Wellcome Trust Sanger Institute, which was launched in 1999 in response to the imminent UniProt is the uni versal prot ein resource a central repository of Protein data created by combining Swiss-Prot, TrEMBL PubMed is a free search engine for accessing the MEDLINE database of citations and abstracts of biomedical research articles History See also History of genetics The existence of genes was first suggested by Gregor Mendel (1822-1884 who in the 1860s studied inheritance [1]
The protein encoded by this gene is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and functions of exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. The complex is also essential for the biogenesis of epithelial cell surface polarity. [1]
References
Further reading
- Hsu SC, TerBush D, Abraham M, Guo W (2004). "The exocyst complex in polarized exocytosis. ". Int. Rev. Cytol. 233: 243–65. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 15037366.
- Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery. ". Genome Res. 6 (9): 791–806. PMID 8889548.
- Guo W, Roth D, Gatti E, et al. (1997). "Identification and characterization of homologues of the Exocyst component Sec10p. ". FEBS Lett. 404 (2-3): 135–9. PMID 9119050.
- Kee Y, Yoo JS, Hazuka CD, et al. (1998). "Subunit structure of the mammalian exocyst complex. ". Proc. Natl. Acad. Sci. U. S. A. 94 (26): 14438–43. PMID 9405631.
- Hsu SC, Hazuka CD, Roth R, et al. (1998). "Subunit composition, protein interactions, and structures of the mammalian brain sec6/8 complex and septin filaments. ". Neuron 20 (6): 1111–22. PMID 9655500.
- Brymora A, Valova VA, Larsen MR, et al. (2001). "The brain exocyst complex interacts with RalA in a GTP-dependent manner: identification of a novel mammalian Sec3 gene and a second Sec15 gene. ". J. Biol. Chem. 276 (32): 29792–7. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 11406615.
- Polzin A, Shipitsin M, Goi T, et al. (2002). "Ral-GTPase influences the regulation of the readily releasable pool of synaptic vesicles. ". Mol. Cell. Biol. 22 (6): 1714–22. PMID 11865051.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. ". Proc. Natl. Acad. Sci. U. S. A. 99 (26): 16899–903. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 12477932.
- Inoue M, Chang L, Hwang J, et al. (2003). "The exocyst complex is required for targeting of Glut4 to the plasma membrane by insulin. ". Nature 422 (6932): 629–33. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 12687004.
- Moskalenko S, Tong C, Rosse C, et al. (2004). "Ral GTPases regulate exocyst assembly through dual subunit interactions. ". J. Biol. Chem. 278 (51): 51743–8. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 14525976.
- Prigent M, Dubois T, Raposo G, et al. (2004). "ARF6 controls post-endocytic recycling through its downstream exocyst complex effector. ". J. Cell Biol. 163 (5): 1111–21. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 14662749.
- Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. ". Nat. Biotechnol. 22 (6): 707–16. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 15146197.
- Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. ". Cell 125 (4): 801–14. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 16713569.
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