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Erbb2 interacting protein
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| PDB rendering based on 1mfg. The Protein Data Bank ( PDB) is a repository for 3-D structural data of Proteins and Nucleic acids These data typically obtained by X-ray crystallography | ||
| Available structures: 1mfg, 1mfl, 1n7t, 2h3l | ||
| Identifiers | ||
| Symbol(s) | ERBB2IP; LAP2; ERBIN | |
| External IDs | OMIM: 606944 MGI: 1890169 HomoloGene: 41282 | |
| RNA expression pattern | ||
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| Orthologs | ||
| Human | Mouse | |
| Entrez | 55914 | 59079 |
| Ensembl | ENSG00000112851 | ENSMUSG00000021709 |
| Uniprot | Q96RT1 | Q80TH2 |
| Refseq | NM_001006600 (mRNA) NP_001006600 (protein) |
NM_001005868 (mRNA) NP_001005868 (protein) |
| Location | Chr 5: 65.26 - 65.41 Mb | Chr 13: 104.94 - 105.04 Mb |
| Pubmed search | [1] | [2] |
Erbb2 interacting protein, also known as ERBB2IP, is a human gene. The Human Genome Organisation (HUGO is an organization involved in the Human Genome Project, a project about mapping the human genome The Mouse Genome Informatics (MGI website is run by The Jackson Laboratory. HomoloGene, a tool of the National Center for Biotechnology Information (NCBI is a system for automated detection of homologs (similarity attributable to descent The Entrez Global Query Cross-Database Search System is a powerful Federated search engine or Web portal that allows users to search many discrete Health sciences Ensembl is a joint scientific project between the European Bioinformatics Institute and the Wellcome Trust Sanger Institute, which was launched in 1999 in response to the imminent UniProt is the uni versal prot ein resource a central repository of Protein data created by combining Swiss-Prot, TrEMBL PubMed is a free search engine for accessing the MEDLINE database of citations and abstracts of biomedical research articles History See also History of genetics The existence of genes was first suggested by Gregor Mendel (1822-1884 who in the 1860s studied inheritance [1]
This gene is a member of the leucine-rich repeat and PDZ domain (LAP) family. The encoded protein contains 17 leucine-rich repeats and one PDZ domain. It binds to the unphosphorylated form of the ERBB2 protein and regulates ERBB2 function and localization. It has also been shown to affect the Ras signaling pathway by disrupting Ras-Raf interaction. Alternate transcriptional splice variants encoding different isoforms have been found for this gene, but only two of them have been characterized to date. [1]
References
Further reading
- Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. ". DNA Res. 9 (3): 99–106. PMID 12168954.
- Kolch W (2003). "Erbin: sorting out ErbB2 receptors or giving Ras a break?". Sci. STKE 2003 (199): pe37. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 12966186.
- Nagase T, Ishikawa K, Kikuno R, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. ". DNA Res. 6 (5): 337–45. PMID 10574462.
- Borg JP, Marchetto S, Le Bivic A, et al. (2000). "ERBIN: a basolateral PDZ protein that interacts with the mammalian ERBB2/HER2 receptor. ". Nat. Cell Biol. 2 (7): 407–14. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 10878805.
- Jaulin-Bastard F, Saito H, Le Bivic A, et al. (2001). "The ERBB2/HER2 receptor differentially interacts with ERBIN and PICK1 PSD-95/DLG/ZO-1 domain proteins. ". J. Biol. Chem. 276 (18): 15256–63. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 11278603.
- Huang YZ, Wang Q, Xiong WC, Mei L (2001). "Erbin is a protein concentrated at postsynaptic membranes that interacts with PSD-95. ". J. Biol. Chem. 276 (22): 19318–26. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 11279080.
- Favre B, Fontao L, Koster J, et al. (2001). "The hemidesmosomal protein bullous pemphigoid antigen 1 and the integrin beta 4 subunit bind to ERBIN. Molecular cloning of multiple alternative splice variants of ERBIN and analysis of their tissue expression. ". J. Biol. Chem. 276 (35): 32427–36. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 11375975.
- Saito H, Santoni MJ, Arsanto JP, et al. (2001). "Lano, a novel LAP protein directly connected to MAGUK proteins in epithelial cells. ". J. Biol. Chem. 276 (34): 32051–5. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 11440998.
- Jaulin-Bastard F, Arsanto JP, Le Bivic A, et al. (2002). "Interaction between Erbin and a Catenin-related protein in epithelial cells. ". J. Biol. Chem. 277 (4): 2869–75. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 11711544.
- Laura RP, Witt AS, Held HA, et al. (2002). "The Erbin PDZ domain binds with high affinity and specificity to the carboxyl termini of delta-catenin and ARVCF. ". J. Biol. Chem. 277 (15): 12906–14. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 11821434.
- Izawa I, Nishizawa M, Tomono Y, et al. (2002). "ERBIN associates with p0071, an armadillo protein, at cell-cell junctions of epithelial cells. ". Genes Cells 7 (5): 475–85. PMID 12047349.
- Ohno H, Hirabayashi S, Iizuka T, et al. (2002). "Localization of p0071-interacting proteins, plakophilin-related armadillo-repeat protein-interacting protein (PAPIN) and ERBIN, in epithelial cells. ". Oncogene 21 (46): 7042–9. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 12370826.
- Huang YZ, Zang M, Xiong WC, et al. (2003). "Erbin suppresses the MAP kinase pathway. ". J. Biol. Chem. 278 (2): 1108–14. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 12379659.
- Birrane G, Chung J, Ladias JA (2003). "Novel mode of ligand recognition by the Erbin PDZ domain. ". J. Biol. Chem. 278 (3): 1399–402. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 12444095.
- Skelton NJ, Koehler MF, Zobel K, et al. (2003). "Origins of PDZ domain ligand specificity. Structure determination and mutagenesis of the Erbin PDZ domain. ". J. Biol. Chem. 278 (9): 7645–54. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 12446668.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. ". Proc. Natl. Acad. Sci. U. S. A. 99 (26): 16899–903. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 12477932.
- Warner DR, Pisano MM, Roberts EA, Greene RM (2003). "Identification of three novel Smad binding proteins involved in cell polarity. ". FEBS Lett. 539 (1-3): 167–73. PMID 12650946.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs. ". Nat. Genet. 36 (1): 40–5. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 14702039.
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