|
EPH receptor B4
|
||
 |
||
| PDB rendering based on 2bba. The Protein Data Bank ( PDB) is a repository for 3-D structural data of Proteins and Nucleic acids These data typically obtained by X-ray crystallography | ||
| Available structures: 2bba, 2hle | ||
| Identifiers | ||
| Symbol(s) | EPHB4; HTK; MYK1; TYRO11 | |
| External IDs | OMIM: 600011 MGI: 104757 HomoloGene: 20939 | |
| RNA expression pattern | ||
|
|
||
| Orthologs | ||
| Human | Mouse | |
| Entrez | 2050 | 13846 |
| Ensembl | ENSG00000196411 | ENSMUSG00000029710 |
| Uniprot | P54760 | Q3V1K8 |
| Refseq | NM_004444 (mRNA) NP_004435 (protein) |
NM_010144 (mRNA) NP_034274 (protein) |
| Location | Chr 7: 100.24 - 100.26 Mb | Chr 5: 137.58 - 137.6 Mb |
| Pubmed search | [1] | [2] |
EPH receptor B4, also known as EPHB4, is a human gene. The Human Genome Organisation (HUGO is an organization involved in the Human Genome Project, a project about mapping the human genome The Mouse Genome Informatics (MGI website is run by The Jackson Laboratory. HomoloGene, a tool of the National Center for Biotechnology Information (NCBI is a system for automated detection of homologs (similarity attributable to descent The Entrez Global Query Cross-Database Search System is a powerful Federated search engine or Web portal that allows users to search many discrete Health sciences Ensembl is a joint scientific project between the European Bioinformatics Institute and the Wellcome Trust Sanger Institute, which was launched in 1999 in response to the imminent UniProt is the uni versal prot ein resource a central repository of Protein data created by combining Swiss-Prot, TrEMBL PubMed is a free search engine for accessing the MEDLINE database of citations and abstracts of biomedical research articles History See also History of genetics The existence of genes was first suggested by Gregor Mendel (1822-1884 who in the 1860s studied inheritance [1]
Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene binds to ephrin-B2 and plays an essential role in vascular development. [1]
References
Further reading
- Flanagan JG, Vanderhaeghen P (1998). "The ephrins and Eph receptors in neural development. ". Annu. Rev. Neurosci. 21: 309–45. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 9530499.
- Zhou R (1998). "The Eph family receptors and ligands. ". Pharmacol. Ther. 77 (3): 151–81. PMID 9576626.
- Holder N, Klein R (1999). "Eph receptors and ephrins: effectors of morphogenesis. ". Development 126 (10): 2033–44. PMID 10207129.
- Wilkinson DG (2000). "Eph receptors and ephrins: regulators of guidance and assembly. ". Int. Rev. Cytol. 196: 177–244. PMID 10730216.
- Xu Q, Mellitzer G, Wilkinson DG (2001). "Roles of Eph receptors and ephrins in segmental patterning. ". Philos. Trans. R. Soc. Lond. , B, Biol. Sci. 355 (1399): 993–1002. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 11128993.
- Wilkinson DG (2001). "Multiple roles of EPH receptors and ephrins in neural development. ". Nat. Rev. Neurosci. 2 (3): 155–64. PMID 11256076.
- Andres AC, Reid HH, Zürcher G, et al. (1994). "Expression of two novel eph-related receptor protein tyrosine kinases in mammary gland development and carcinogenesis. ". Oncogene 9 (5): 1461–7. PMID 8152808.
- Bennett BD, Wang Z, Kuang WJ, et al. (1994). "Cloning and characterization of HTK, a novel transmembrane tyrosine kinase of the EPH subfamily. ". J. Biol. Chem. 269 (19): 14211–8. PMID 8188704.
- Berclaz G, Andres AC, Albrecht D, et al. (1996). "Expression of the receptor protein tyrosine kinase myk-1/htk in normal and malignant mammary epithelium. ". Biochem. Biophys. Res. Commun. 226 (3): 869–75. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 8831703.
- "Unified nomenclature for Eph family receptors and their ligands, the ephrins. Eph Nomenclature Committee. " (1997). Cell 90 (3): 403–4. PMID 9267020.
- Nikolova Z, Djonov V, Zuercher G, et al. (1998). "Cell-type specific and estrogen dependent expression of the receptor tyrosine kinase EphB4 and its ligand ephrin-B2 during mammary gland morphogenesis. ". J. Cell. Sci. 111 ( Pt 18): 2741–51. PMID 9718367.
- Tang XX, Brodeur GM, Campling BG, Ikegaki N (1999). "Coexpression of transcripts encoding EPHB receptor protein tyrosine kinases and their ephrin-B ligands in human small cell lung carcinoma. ". Clin. Cancer Res. 5 (2): 455–60. PMID 10037197.
- Gerety SS, Wang HU, Chen ZF, Anderson DJ (1999). "Symmetrical mutant phenotypes of the receptor EphB4 and its specific transmembrane ligand ephrin-B2 in cardiovascular development. ". Mol. Cell 4 (3): 403–14. PMID 10518221.
- Dalva MB, Takasu MA, Lin MZ, et al. (2001). "EphB receptors interact with NMDA receptors and regulate excitatory synapse formation. ". Cell 103 (6): 945–56. PMID 11136979.
- Wilson MD, Riemer C, Martindale DW, et al. (2001). "Comparative analysis of the gene-dense ACHE/TFR2 region on human chromosome 7q22 with the orthologous region on mouse chromosome 5. ". Nucleic Acids Res. 29 (6): 1352–65. PMID 11239002.
Dapyx Software network: MP3 Explorer | Ebook Manager | Zenithic