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EPH receptor B2
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| PDB rendering based on 1b4f. The Protein Data Bank ( PDB) is a repository for 3-D structural data of Proteins and Nucleic acids These data typically obtained by X-ray crystallography | ||
| Available structures: 1b4f, 1f0m, 1jpa, 1kgy, 1nuk, 1sgg, 1shw, 2hen | ||
| Identifiers | ||
| Symbol(s) | EPHB2; CAPB; DRT; EPHT3; ERK; Hek5; MGC87492; PCBC; Tyro5 | |
| External IDs | OMIM: 600997 MGI: 99611 HomoloGene: 37925 | |
| RNA expression pattern | ||
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| Orthologs | ||
| Human | Mouse | |
| Entrez | 2048 | 13844 |
| Ensembl | ENSG00000133216 | ENSMUSG00000028664 |
| Uniprot | P29323 | Q6GTQ7 |
| Refseq | NM_004442 (mRNA) NP_004433 (protein) |
NM_010142 (mRNA) NP_034272 (protein) |
| Location | Chr 1: 22.91 - 23.11 Mb | Chr 4: 135.93 - 136.11 Mb |
| Pubmed search | [1] | [2] |
EPH receptor B2, also known as EPHB2, is a human gene. The Human Genome Organisation (HUGO is an organization involved in the Human Genome Project, a project about mapping the human genome The Mouse Genome Informatics (MGI website is run by The Jackson Laboratory. HomoloGene, a tool of the National Center for Biotechnology Information (NCBI is a system for automated detection of homologs (similarity attributable to descent The Entrez Global Query Cross-Database Search System is a powerful Federated search engine or Web portal that allows users to search many discrete Health sciences Ensembl is a joint scientific project between the European Bioinformatics Institute and the Wellcome Trust Sanger Institute, which was launched in 1999 in response to the imminent UniProt is the uni versal prot ein resource a central repository of Protein data created by combining Swiss-Prot, TrEMBL PubMed is a free search engine for accessing the MEDLINE database of citations and abstracts of biomedical research articles History See also History of genetics The existence of genes was first suggested by Gregor Mendel (1822-1884 who in the 1860s studied inheritance
Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. In Molecular biology, ephrins and Eph receptors are components of Cell signaling pathways involved in Animal development In Biochemistry, a ligand ( latin ligare = to bind is a substance that is able to bind to and form a complex with a Biomolecule The nervous system is a Network of specialized cells that communicate information about an animal's surroundings and itself Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. A transmembrane protein is a Protein that spans the entire Biological membrane. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. Receptor tyrosine kinases (RTKs are the high affinity Cell surface receptors for many polypeptide Growth factors Cytokines and Hormones The protein encoded by this gene is a receptor for ephrin-B family members. [1]
References
This article incorporates text from the United States National Library of Medicine, which is in the public domain. The United States National Library of Medicine ( NLM) operated by the United States federal government, is the world's largest Medical library. The public domain is a range of abstract materials &ndash commonly referred to as Intellectual property &ndash which are not owned or controlled by anyone
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