|
EPH receptor B1
|
||
 |
||
| PDB rendering based on 2djs. The Protein Data Bank ( PDB) is a repository for 3-D structural data of Proteins and Nucleic acids These data typically obtained by X-ray crystallography | ||
| Available structures: 2djs | ||
| Identifiers | ||
| Symbol(s) | EPHB1; NET; ELK; EPHT2; FLJ37986; Hek6 | |
| External IDs | OMIM: 600600 MGI: 1096337 HomoloGene: 20936 | |
| Orthologs | ||
| Human | Mouse | |
| Entrez | 2047 | 270190 |
| Ensembl | n/a | ENSMUSG00000032537 |
| Uniprot | n/a | Q8CA63 |
| Refseq | NM_004441 (mRNA) NP_004432 (protein) |
NM_173447 (mRNA) NP_775623 (protein) |
| Location | n/a | Chr 9: 101.78 - 102.08 Mb |
| Pubmed search | [1] | [2] |
EPH receptor B1, also known as EPHB1, is a human gene. The Human Genome Organisation (HUGO is an organization involved in the Human Genome Project, a project about mapping the human genome The Mouse Genome Informatics (MGI website is run by The Jackson Laboratory. HomoloGene, a tool of the National Center for Biotechnology Information (NCBI is a system for automated detection of homologs (similarity attributable to descent The Entrez Global Query Cross-Database Search System is a powerful Federated search engine or Web portal that allows users to search many discrete Health sciences Ensembl is a joint scientific project between the European Bioinformatics Institute and the Wellcome Trust Sanger Institute, which was launched in 1999 in response to the imminent UniProt is the uni versal prot ein resource a central repository of Protein data created by combining Swiss-Prot, TrEMBL PubMed is a free search engine for accessing the MEDLINE database of citations and abstracts of biomedical research articles History See also History of genetics The existence of genes was first suggested by Gregor Mendel (1822-1884 who in the 1860s studied inheritance [1]
Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene is a receptor for ephrin-B family members. [1]
References
Further reading
- Flanagan JG, Vanderhaeghen P (1998). "The ephrins and Eph receptors in neural development. ". Annu. Rev. Neurosci. 21: 309–45. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 9530499.
- Zhou R (1998). "The Eph family receptors and ligands. ". Pharmacol. Ther. 77 (3): 151–81. PMID 9576626.
- Abrahamson DR, Robert B, Hyink DP, et al. (1998). "Origins and formation of microvasculature in the developing kidney. ". Kidney Int. Suppl. 67: S7–11. PMID 9736245.
- Holder N, Klein R (1999). "Eph receptors and ephrins: effectors of morphogenesis. ". Development 126 (10): 2033–44. PMID 10207129.
- Wilkinson DG (2000). "Eph receptors and ephrins: regulators of guidance and assembly. ". Int. Rev. Cytol. 196: 177–244. PMID 10730216.
- Xu Q, Mellitzer G, Wilkinson DG (2001). "Roles of Eph receptors and ephrins in segmental patterning. ". Philos. Trans. R. Soc. Lond. , B, Biol. Sci. 355 (1399): 993–1002. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 11128993.
- Wilkinson DG (2001). "Multiple roles of EPH receptors and ephrins in neural development. ". Nat. Rev. Neurosci. 2 (3): 155–64. PMID 11256076.
- Larose L, Gish G, Shoelson S, Pawson T (1993). "Identification of residues in the beta platelet-derived growth factor receptor that confer specificity for binding to phospholipase C-gamma 1. ". Oncogene 8 (9): 2493–9. PMID 7689724.
- Davis S, Gale NW, Aldrich TH, et al. (1994). "Ligands for EPH-related receptor tyrosine kinases that require membrane attachment or clustering for activity. ". Science 266 (5186): 816–9. PMID 7973638.
- Beckmann MP, Cerretti DP, Baum P, et al. (1994). "Molecular characterization of a family of ligands for eph-related tyrosine kinase receptors. ". EMBO J. 13 (16): 3757–62. PMID 8070404.
- Cerretti DP, Vanden Bos T, Nelson N, et al. (1996). "Isolation of LERK-5: a ligand of the eph-related receptor tyrosine kinases. ". Mol. Immunol. 32 (16): 1197–205. PMID 8559144.
- Tang XX, Biegel JA, Nycum LM, et al. (1996). "cDNA cloning, molecular characterization, and chromosomal localization of NET(EPHT2), a human EPH-related receptor protein-tyrosine kinase gene preferentially expressed in brain. ". Genomics 29 (2): 426–37. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 8666391.
- Gale NW, Holland SJ, Valenzuela DM, et al. (1996). "Eph receptors and ligands comprise two major specificity subclasses and are reciprocally compartmentalized during embryogenesis. ". Neuron 17 (1): 9–19. PMID 8755474.
- Stein E, Cerretti DP, Daniel TO (1996). "Ligand activation of ELK receptor tyrosine kinase promotes its association with Grb10 and Grb2 in vascular endothelial cells. ". J. Biol. Chem. 271 (38): 23588–93. PMID 8798570.
- Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery. ". Genome Res. 6 (9): 791–806. PMID 8889548.
- Kozlosky CJ, VandenBos T, Park L, et al. (1997). "LERK-7: a ligand of the Eph-related kinases is developmentally regulated in the brain. ". Cytokine 9 (8): 540–9. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 9245480.
- "Unified nomenclature for Eph family receptors and their ligands, the ephrins. Eph Nomenclature Committee. " (1997). Cell 90 (3): 403–4. PMID 9267020.
- Stein E, Huynh-Do U, Lane AA, et al. (1998). "Nck recruitment to Eph receptor, EphB1/ELK, couples ligand activation to c-Jun kinase. ". J. Biol. Chem. 273 (3): 1303–8. PMID 9430661.
- Stein E, Lane AA, Cerretti DP, et al. (1998). "Eph receptors discriminate specific ligand oligomers to determine alternative signaling complexes, attachment, and assembly responses. ". Genes Dev. 12 (5): 667–78. PMID 9499402.
Dapyx Software network: MP3 Explorer | Ebook Manager | Zenithic