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EPH receptor A4
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| PDB rendering based on 1b0x. The Protein Data Bank ( PDB) is a repository for 3-D structural data of Proteins and Nucleic acids These data typically obtained by X-ray crystallography | ||
| Available structures: 1b0x, 2hel | ||
| Identifiers | ||
| Symbol(s) | EPHA4; HEK8; SEK; TYRO1 | |
| External IDs | OMIM: 602188 MGI: 98277 HomoloGene: 20933 | |
| RNA expression pattern | ||
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| Orthologs | ||
| Human | Mouse | |
| Entrez | 2043 | 13838 |
| Ensembl | ENSG00000116106 | ENSMUSG00000026235 |
| Uniprot | P54764 | Q3V1W9 |
| Refseq | NM_004438 (mRNA) NP_004429 (protein) |
NM_007936 (mRNA) NP_031962 (protein) |
| Location | Chr 2: 221.99 - 222.15 Mb | Chr 1: 77.25 - 77.4 Mb |
| Pubmed search | [1] | [2] |
EPH receptor A4, also known as EPHA4, is a human gene. The Human Genome Organisation (HUGO is an organization involved in the Human Genome Project, a project about mapping the human genome The Mouse Genome Informatics (MGI website is run by The Jackson Laboratory. HomoloGene, a tool of the National Center for Biotechnology Information (NCBI is a system for automated detection of homologs (similarity attributable to descent The Entrez Global Query Cross-Database Search System is a powerful Federated search engine or Web portal that allows users to search many discrete Health sciences Ensembl is a joint scientific project between the European Bioinformatics Institute and the Wellcome Trust Sanger Institute, which was launched in 1999 in response to the imminent UniProt is the uni versal prot ein resource a central repository of Protein data created by combining Swiss-Prot, TrEMBL PubMed is a free search engine for accessing the MEDLINE database of citations and abstracts of biomedical research articles History See also History of genetics The existence of genes was first suggested by Gregor Mendel (1822-1884 who in the 1860s studied inheritance [1]
This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. [1]
References
Further reading
- Flanagan JG, Vanderhaeghen P (1998). "The ephrins and Eph receptors in neural development. ". Annu. Rev. Neurosci. 21: 309–45. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 9530499.
- Zhou R (1998). "The Eph family receptors and ligands. ". Pharmacol. Ther. 77 (3): 151–81. PMID 9576626.
- Holder N, Klein R (1999). "Eph receptors and ephrins: effectors of morphogenesis. ". Development 126 (10): 2033–44. PMID 10207129.
- Wilkinson DG (2000). "Eph receptors and ephrins: regulators of guidance and assembly. ". Int. Rev. Cytol. 196: 177–244. PMID 10730216.
- Xu Q, Mellitzer G, Wilkinson DG (2001). "Roles of Eph receptors and ephrins in segmental patterning. ". Philos. Trans. R. Soc. Lond. , B, Biol. Sci. 355 (1399): 993–1002. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 11128993.
- Wilkinson DG (2001). "Multiple roles of EPH receptors and ephrins in neural development. ". Nat. Rev. Neurosci. 2 (3): 155–64. PMID 11256076.
- Fox GM, Holst PL, Chute HT, et al. (1995). "cDNA cloning and tissue distribution of five human EPH-like receptor protein-tyrosine kinases. ". Oncogene 10 (5): 897–905. PMID 7898931.
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. ". Gene 138 (1-2): 171–4. PMID 8125298.
- Ellis C, Kasmi F, Ganju P, et al. (1996). "A juxtamembrane autophosphorylation site in the Eph family receptor tyrosine kinase, Sek, mediates high affinity interaction with p59fyn. ". Oncogene 12 (8): 1727–36. PMID 8622893.
- Gale NW, Holland SJ, Valenzuela DM, et al. (1996). "Eph receptors and ligands comprise two major specificity subclasses and are reciprocally compartmentalized during embryogenesis. ". Neuron 17 (1): 9–19. PMID 8755474.
- Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery. ". Genome Res. 6 (9): 791–806. PMID 8889548.
- "Unified nomenclature for Eph family receptors and their ligands, the ephrins. Eph Nomenclature Committee. " (1997). Cell 90 (3): 403–4. PMID 9267020.
- Aasheim HC, Terstappen LW, Logtenberg T (1997). "Regulated expression of the Eph-related receptor tyrosine kinase Hek11 in early human B lymphopoiesis. ". Blood 90 (9): 3613–22. PMID 9345045.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. ". Gene 200 (1-2): 149–56. PMID 9373149.
- Bergemann AD, Zhang L, Chiang MK, et al. (1998). "Ephrin-B3, a ligand for the receptor EphB3, expressed at the midline of the developing neural tube. ". Oncogene 16 (4): 471–80. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 9484836.
- Janis LS, Cassidy RM, Kromer LF (1999). "Ephrin-A binding and EphA receptor expression delineate the matrix compartment of the striatum. ". J. Neurosci. 19 (12): 4962–71. PMID 10366629.
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