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EPH receptor B6
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| Identifiers | ||
| Symbol(s) | EPHB6; HEP; MGC129910; MGC129911 | |
| External IDs | OMIM: 602757 MGI: 1096338 HomoloGene: 20940 | |
| RNA expression pattern | ||
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| Orthologs | ||
| Human | Mouse | |
| Entrez | 2051 | 13848 |
| Ensembl | ENSG00000106123 | ENSMUSG00000029869 |
| Uniprot | O15197 | Q3TQ77 |
| Refseq | NM_004445 (mRNA) NP_004436 (protein) |
NM_007680 (mRNA) NP_031706 (protein) |
| Location | Chr 7: 142.27 - 142.28 Mb | Chr 6: 41.54 - 41.55 Mb |
| Pubmed search | [1] | [2] |
EPH receptor B6, also known as EPHB6, is a human gene. The Human Genome Organisation (HUGO is an organization involved in the Human Genome Project, a project about mapping the human genome The Mouse Genome Informatics (MGI website is run by The Jackson Laboratory. HomoloGene, a tool of the National Center for Biotechnology Information (NCBI is a system for automated detection of homologs (similarity attributable to descent The Entrez Global Query Cross-Database Search System is a powerful Federated search engine or Web portal that allows users to search many discrete Health sciences Ensembl is a joint scientific project between the European Bioinformatics Institute and the Wellcome Trust Sanger Institute, which was launched in 1999 in response to the imminent UniProt is the uni versal prot ein resource a central repository of Protein data created by combining Swiss-Prot, TrEMBL PubMed is a free search engine for accessing the MEDLINE database of citations and abstracts of biomedical research articles History See also History of genetics The existence of genes was first suggested by Gregor Mendel (1822-1884 who in the 1860s studied inheritance [1]
Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The ephrin receptor encoded by this gene lacks the kinase activity of most receptor tyrosine kinases and binds to ephrin-B ligands. [1]
References
Further reading
- Flanagan JG, Vanderhaeghen P (1998). "The ephrins and Eph receptors in neural development. ". Annu. Rev. Neurosci. 21: 309-45. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 9530499.
- Zhou R (1998). "The Eph family receptors and ligands. ". Pharmacol. Ther. 77 (3): 151-81. PMID 9576626.
- Holder N, Klein R (1999). "Eph receptors and ephrins: effectors of morphogenesis. ". Development 126 (10): 2033-44. PMID 10207129.
- Wilkinson DG (2000). "Eph receptors and ephrins: regulators of guidance and assembly. ". Int. Rev. Cytol. 196: 177-244. PMID 10730216.
- Xu Q, Mellitzer G, Wilkinson DG (2001). "Roles of Eph receptors and ephrins in segmental patterning. ". Philos. Trans. R. Soc. Lond. , B, Biol. Sci. 355 (1399): 993-1002. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 11128993.
- Wilkinson DG (2001). "Multiple roles of EPH receptors and ephrins in neural development. ". Nat. Rev. Neurosci. 2 (3): 155-64. PMID 11256076.
- Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery. ". Genome Res. 6 (9): 791-806. PMID 8889548.
- Matsuoka H, Iwata N, Ito M, et al. (1997). "Expression of a kinase-defective Eph-like receptor in the normal human brain. ". Biochem. Biophys. Res. Commun. 235 (3): 487-92. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 9207182.
- "Unified nomenclature for Eph family receptors and their ligands, the ephrins. Eph Nomenclature Committee. " (1997). Cell 90 (3): 403-4. PMID 9267020.
- Hock B, Böhme B, Karn T, et al. (1998). "PDZ-domain-mediated interaction of the Eph-related receptor tyrosine kinase EphB3 and the ras-binding protein AF6 depends on the kinase activity of the receptor. ". Proc. Natl. Acad. Sci. U. S. A. 95 (17): 9779-84. PMID 9707552.
- Munthe E, Rian E, Holien T, et al. (2000). "Ephrin-B2 is a candidate ligand for the Eph receptor, EphB6. ". FEBS Lett. 466 (1): 169-74. PMID 10648835.
- Shimoyama M, Matsuoka H, Tamekane A, et al. (2000). "T-cell-specific expression of kinase-defective Eph-family receptor protein, EphB6 in normal as well as transformed hematopoietic cells. ". Growth Factors 18 (1): 63-78. PMID 10831073.
- Tang XX, Zhao H, Robinson ME, et al. (2000). "Implications of EPHB6, EFNB2, and EFNB3 expressions in human neuroblastoma. ". Proc. Natl. Acad. Sci. U. S. A. 97 (20): 10936-41. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 10984508.
- Luo H, Wan X, Wu Y, Wu J (2001). "Cross-linking of EphB6 resulting in signal transduction and apoptosis in Jurkat cells. ". J. Immunol. 167 (3): 1362-70. PMID 11466354.
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