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EPH receptor A8
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| PDB rendering based on 1ucv. The Protein Data Bank ( PDB) is a repository for 3-D structural data of Proteins and Nucleic acids These data typically obtained by X-ray crystallography | ||
| Available structures: 1ucv, 1x5l | ||
| Identifiers | ||
| Symbol(s) | EPHA8; EEK; HEK3; KIAA1459 | |
| External IDs | OMIM: 176945 MGI: 109378 HomoloGene: 22436 | |
| Orthologs | ||
| Human | Mouse | |
| Entrez | 2046 | 13842 |
| Ensembl | ENSG00000070886 | ENSMUSG00000028661 |
| Uniprot | P29322 | Q5DTX7 |
| Refseq | NM_001006943 (mRNA) NP_001006944 (protein) |
NM_007939 (mRNA) NP_031965 (protein) |
| Location | Chr 1: 22.76 - 22.8 Mb | Chr 4: 136.2 - 136.23 Mb |
| Pubmed search | [1] | [2] |
EPH receptor A8, also known as EPHA8, is a human gene. The Human Genome Organisation (HUGO is an organization involved in the Human Genome Project, a project about mapping the human genome The Mouse Genome Informatics (MGI website is run by The Jackson Laboratory. HomoloGene, a tool of the National Center for Biotechnology Information (NCBI is a system for automated detection of homologs (similarity attributable to descent The Entrez Global Query Cross-Database Search System is a powerful Federated search engine or Web portal that allows users to search many discrete Health sciences Ensembl is a joint scientific project between the European Bioinformatics Institute and the Wellcome Trust Sanger Institute, which was launched in 1999 in response to the imminent UniProt is the uni versal prot ein resource a central repository of Protein data created by combining Swiss-Prot, TrEMBL PubMed is a free search engine for accessing the MEDLINE database of citations and abstracts of biomedical research articles History See also History of genetics The existence of genes was first suggested by Gregor Mendel (1822-1884 who in the 1860s studied inheritance [1]
This gene encodes a member of the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. The protein encoded by this gene functions as a receptor for ephrin A2, A3 and A5 and plays a role in short-range contact-mediated axonal guidance during development of the mammalian nervous system. [1]
References
Further reading
- Flanagan JG, Vanderhaeghen P (1998). "The ephrins and Eph receptors in neural development. ". Annu. Rev. Neurosci. 21: 309–45. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 9530499.
- Holland SJ, Peles E, Pawson T, Schlessinger J (1998). "Cell-contact-dependent signalling in axon growth and guidance: Eph receptor tyrosine kinases and receptor protein tyrosine phosphatase beta. ". Curr. Opin. Neurobiol. 8 (1): 117–27. PMID 9568399.
- Zhou R (1998). "The Eph family receptors and ligands. ". Pharmacol. Ther. 77 (3): 151–81. PMID 9576626.
- Holder N, Klein R (1999). "Eph receptors and ephrins: effectors of morphogenesis. ". Development 126 (10): 2033–44. PMID 10207129.
- Wilkinson DG (2000). "Eph receptors and ephrins: regulators of guidance and assembly. ". Int. Rev. Cytol. 196: 177–244. PMID 10730216.
- Xu Q, Mellitzer G, Wilkinson DG (2001). "Roles of Eph receptors and ephrins in segmental patterning. ". Philos. Trans. R. Soc. Lond. , B, Biol. Sci. 355 (1399): 993–1002. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 11128993.
- Wilkinson DG (2001). "Multiple roles of EPH receptors and ephrins in neural development. ". Nat. Rev. Neurosci. 2 (3): 155–64. PMID 11256076.
- Nakamoto T, Kain KH, Ginsberg MH (2004). "Neurobiology: New connections between integrins and axon guidance. ". Curr. Biol. 14 (3): R121–3. PMID 14986683.
- Yamaguchi Y, Pasquale EB (2004). "Eph receptors in the adult brain. ". Curr. Opin. Neurobiol. 14 (3): 288–96. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 15194108.
- Murai KK, Pasquale EB (2004). "Eph receptors, ephrins, and synaptic function. ". The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry 10 (4): 304–14. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 15271258.
- Chan J, Watt VM (1991). "eek and erk, new members of the eph subclass of receptor protein-tyrosine kinases. ". Oncogene 6 (6): 1057–61. PMID 1648701.
- Park S, Sánchez MP (1997). "The Eek receptor, a member of the Eph family of tyrosine protein kinases, can be activated by three different Eph family ligands. ". Oncogene 14 (5): 533–42. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 9053851.
- Park S, Frisén J, Barbacid M (1997). "Aberrant axonal projections in mice lacking EphA8 (Eek) tyrosine protein kinase receptors. ". EMBO J. 16 (11): 3106–14. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 9214628.
- "Unified nomenclature for Eph family receptors and their ligands, the ephrins. Eph Nomenclature Committee. " (1997). Cell 90 (3): 403–4. PMID 9267020.
- Lemke G (1998). "A coherent nomenclature for Eph receptors and their ligands. ". Mol. Cell. Neurosci. 9 (5-6): 331–2. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 9361271.
- Choi S, Park S (1999). "Phosphorylation at Tyr-838 in the kinase domain of EphA8 modulates Fyn binding to the Tyr-615 site by enhancing tyrosine kinase activity. ". Oncogene 18 (39): 5413–22. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 10498895.
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