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EPH receptor A3
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| PDB rendering based on 2gsf. The Protein Data Bank ( PDB) is a repository for 3-D structural data of Proteins and Nucleic acids These data typically obtained by X-ray crystallography | ||
| Available structures: 2gsf | ||
| Identifiers | ||
| Symbol(s) | EPHA3; ETK; ETK1; HEK; HEK4; TYRO4 | |
| External IDs | OMIM: 179611 MGI: 99612 HomoloGene: 21083 | |
| RNA expression pattern | ||
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| Orthologs | ||
| Human | Mouse | |
| Entrez | 2042 | 13837 |
| Ensembl | ENSG00000044524 | ENSMUSG00000052504 |
| Uniprot | P29320 | Q8BRB1 |
| Refseq | NM_005233 (mRNA) NP_005224 (protein) |
NM_010140 (mRNA) NP_034270 (protein) |
| Location | Chr 3: 89.24 - 89.61 Mb | Chr 16: 63.49 - 63.81 Mb |
| Pubmed search | [1] | [2] |
EPH receptor A3, also known as EPHA3, is a human gene. The Human Genome Organisation (HUGO is an organization involved in the Human Genome Project, a project about mapping the human genome The Mouse Genome Informatics (MGI website is run by The Jackson Laboratory. HomoloGene, a tool of the National Center for Biotechnology Information (NCBI is a system for automated detection of homologs (similarity attributable to descent The Entrez Global Query Cross-Database Search System is a powerful Federated search engine or Web portal that allows users to search many discrete Health sciences Ensembl is a joint scientific project between the European Bioinformatics Institute and the Wellcome Trust Sanger Institute, which was launched in 1999 in response to the imminent UniProt is the uni versal prot ein resource a central repository of Protein data created by combining Swiss-Prot, TrEMBL PubMed is a free search engine for accessing the MEDLINE database of citations and abstracts of biomedical research articles History See also History of genetics The existence of genes was first suggested by Gregor Mendel (1822-1884 who in the 1860s studied inheritance [1]
This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene encodes a protein that binds ephrin-A ligands. Two alternatively spliced transcript variants have been described for this gene. [1]
References
Further reading
- Flanagan JG, Vanderhaeghen P (1998). "The ephrins and Eph receptors in neural development. ". Annu. Rev. Neurosci. 21: 309–45. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 9530499.
- Zhou R (1998). "The Eph family receptors and ligands. ". Pharmacol. Ther. 77 (3): 151–81. PMID 9576626.
- Ernst AF, Jurney WM, McLoon SC (1999). "Mechanisms involved in development of retinotectal connections: roles of Eph receptor tyrosine kinases, NMDA receptors and nitric oxide. ". Prog. Brain Res. 118: 115–31. PMID 9932438.
- Holder N, Klein R (1999). "Eph receptors and ephrins: effectors of morphogenesis. ". Development 126 (10): 2033–44. PMID 10207129.
- Wilkinson DG (2000). "Eph receptors and ephrins: regulators of guidance and assembly. ". Int. Rev. Cytol. 196: 177–244. PMID 10730216.
- Xu Q, Mellitzer G, Wilkinson DG (2001). "Roles of Eph receptors and ephrins in segmental patterning. ". Philos. Trans. R. Soc. Lond. , B, Biol. Sci. 355 (1399): 993–1002. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 11128993.
- Wilkinson DG (2001). "Multiple roles of EPH receptors and ephrins in neural development. ". Nat. Rev. Neurosci. 2 (3): 155–64. PMID 11256076.
- Wicks IP, Wilkinson D, Salvaris E, Boyd AW (1992). "Molecular cloning of HEK, the gene encoding a receptor tyrosine kinase expressed by human lymphoid tumor cell lines. ". Proc. Natl. Acad. Sci. U. S. A. 89 (5): 1611–5. PMID 1311845.
- Boyd AW, Ward LD, Wicks IP, et al. (1992). "Isolation and characterization of a novel receptor-type protein tyrosine kinase (hek) from a human pre-B cell line. ". J. Biol. Chem. 267 (5): 3262–7. PMID 1737782.
- Beckmann MP, Cerretti DP, Baum P, et al. (1994). "Molecular characterization of a family of ligands for eph-related tyrosine kinase receptors. ". EMBO J. 13 (16): 3757–62. PMID 8070404.
- Wicks IP, Lapsys NM, Baker E, et al. (1994). "Localization of a human receptor tyrosine kinase (ETK1) to chromosome region 3p11. 2. ". Genomics 19 (1): 38–41. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 8188238.
- Cerretti DP, Vanden Bos T, Nelson N, et al. (1996). "Isolation of LERK-5: a ligand of the eph-related receptor tyrosine kinases. ". Mol. Immunol. 32 (16): 1197–205. PMID 8559144.
- Lackmann M, Mann RJ, Kravets L, et al. (1997). "Ligand for EPH-related kinase (LERK) 7 is the preferred high affinity ligand for the HEK receptor. ". J. Biol. Chem. 272 (26): 16521–30. PMID 9195962.
- Kozlosky CJ, VandenBos T, Park L, et al. (1997). "LERK-7: a ligand of the Eph-related kinases is developmentally regulated in the brain. ". Cytokine 9 (8): 540–9. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 9245480.
- "Unified nomenclature for Eph family receptors and their ligands, the ephrins. Eph Nomenclature Committee. " (1997). Cell 90 (3): 403–4. PMID 9267020.
- Lackmann M, Oates AC, Dottori M, et al. (1998). "Distinct subdomains of the EphA3 receptor mediate ligand binding and receptor dimerization. ". J. Biol. Chem. 273 (32): 20228–37. PMID 9685371.
- Ciossek T, Monschau B, Kremoser C, et al. (1998). "Eph receptor-ligand interactions are necessary for guidance of retinal ganglion cell axons in vitro. ". Eur. J. Neurosci. 10 (5): 1574–80. PMID 9751130.
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