|
Elastase 3A, pancreatic
|
||
| Identifiers | ||
| Symbol(s) | ELA3A; ELA3 | |
| External IDs | HomoloGene: 80852 | |
| Orthologs | ||
| Human | Mouse | |
| Entrez | 10136 | n/a
|
| Refseq | NM_005747 (mRNA) NP_005738 (protein) |
n/a (mRNA) n/a (protein) |
| Pubmed search | [1] | n/a |
Elastase 3A, pancreatic, also known as ELA3A, is a human gene. The Human Genome Organisation (HUGO is an organization involved in the Human Genome Project, a project about mapping the human genome HomoloGene, a tool of the National Center for Biotechnology Information (NCBI is a system for automated detection of homologs (similarity attributable to descent The Entrez Global Query Cross-Database Search System is a powerful Federated search engine or Web portal that allows users to search many discrete Health sciences PubMed is a free search engine for accessing the MEDLINE database of citations and abstracts of biomedical research articles History See also History of genetics The existence of genes was first suggested by Gregor Mendel (1822-1884 who in the 1860s studied inheritance [1]
Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Unlike other elastases, elastase 3A has little elastolytic activity. Like most of the human elastases, elastase 3A is secreted from the pancreas as a zymogen and, like other serine proteases such as trypsin, chymotrypsin and kallikrein, it has a digestive function in the intestine. Elastase 3A preferentially cleaves proteins after alanine residues. Elastase 3A may also function in the intestinal transport and metabolism of cholesterol. Both elastase 3A and elastase 3B have been referred to as protease E and as elastase 1. [1]
References
Further reading
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). ". Genome Res. 14 (10B): 2121-7. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 15489334.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. ". Proc. Natl. Acad. Sci. U. S. A. 99 (26): 16899-903. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 12477932.
- Shimada S, Yamaguchi K, Takahashi M, Ogawa M (2002). "Pancreatic elastase IIIA and its variants are expressed in pancreatic carcinoma cells. ". Int. J. Mol. Med. 10 (5): 599-603. PMID 12373299.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. ". Gene 200 (1-2): 149-56. PMID 9373149.
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. ". Gene 138 (1-2): 171-4. PMID 8125298.
- Tani T, Ohsumi J, Mita K, Takiguchi Y (1988). "Identification of a novel class of elastase isozyme, human pancreatic elastase III, by cDNA and genomic gene cloning. ". J. Biol. Chem. 263 (3): 1231-9. PMID 2826474.
- Shirasu Y, Takemura K, Yoshida H, et al. (1988). "Molecular cloning of complementary DNA encoding one of the human pancreatic protease E isozymes. ". J. Biochem. 104 (2): 259-64. PMID 2460440.
Dapyx Software network: MP3 Explorer | Ebook Manager | Zenithic