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Eukaryotic translation initiation factor 4E binding protein 3
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| Identifiers | ||
| Symbol(s) | EIF4EBP3; 4E-BP3 | |
| External IDs | OMIM: 603483 MGI: 1270847 HomoloGene: 37841 | |
| Orthologs | ||
| Human | Mouse | |
| Entrez | 8637 | 108112 |
| Ensembl | n/a | ENSMUSG00000073595 |
| Uniprot | n/a | Q80VV3 |
| Refseq | NM_003732 (mRNA) NP_003723 (protein) |
NM_201256 (mRNA) NP_957708 (protein) |
| Location | n/a | Chr 18: 36.79 - 36.79 Mb |
| Pubmed search | [1] | [2] |
Eukaryotic translation initiation factor 4E binding protein 3, also known as EIF4EBP3, is a human gene. The Human Genome Organisation (HUGO is an organization involved in the Human Genome Project, a project about mapping the human genome The Mouse Genome Informatics (MGI website is run by The Jackson Laboratory. HomoloGene, a tool of the National Center for Biotechnology Information (NCBI is a system for automated detection of homologs (similarity attributable to descent The Entrez Global Query Cross-Database Search System is a powerful Federated search engine or Web portal that allows users to search many discrete Health sciences Ensembl is a joint scientific project between the European Bioinformatics Institute and the Wellcome Trust Sanger Institute, which was launched in 1999 in response to the imminent UniProt is the uni versal prot ein resource a central repository of Protein data created by combining Swiss-Prot, TrEMBL PubMed is a free search engine for accessing the MEDLINE database of citations and abstracts of biomedical research articles History See also History of genetics The existence of genes was first suggested by Gregor Mendel (1822-1884 who in the 1860s studied inheritance [1]
This gene encodes a member of the EIF4EBP family which derives it name from proteins that bind to eukaryotic initiation factor 4E and that prevent its assembly into EIF4F. Co-transcription of this gene and the neighboring upstream gene (MASK) generates a transcript (MASK-BP3) which encodes a fusion protein comprised of the MASK protein sequence for the majority of the protein and a different C-terminus due to an alternate reading frame for the EIF4EBP3 segments. [1]
References
Further reading
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network. ". Nature 437 (7062): 1173-8. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 16189514.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). ". Genome Res. 14 (10B): 2121-7. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 15489334.
- Joshi B, Cameron A, Jagus R (2004). "Characterization of mammalian eIF4E-family members. ". Eur. J. Biochem. 271 (11): 2189-203. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 15153109.
- Poulin F, Brueschke A, Sonenberg N (2004). "Gene fusion and overlapping reading frames in the mammalian genes for 4E-BP3 and MASK. ". J. Biol. Chem. 278 (52): 52290-7. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 14557257.
- Ferguson G, Mothe-Satney I, Lawrence JC (2004). "Ser-64 and Ser-111 in PHAS-I are dispensable for insulin-stimulated dissociation from eIF4E. ". J. Biol. Chem. 278 (48): 47459-65. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 14507920.
- Kleijn M, Scheper GC, Wilson ML, et al. (2003). "Localisation and regulation of the eIF4E-binding protein 4E-BP3. ". FEBS Lett. 532 (3): 319-23. PMID 12482586.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. ". Proc. Natl. Acad. Sci. U. S. A. 99 (26): 16899-903. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 12477932.
- Poulin F, Gingras AC, Olsen H, et al. (1998). "4E-BP3, a new member of the eukaryotic initiation factor 4E-binding protein family. ". J. Biol. Chem. 273 (22): 14002-7. PMID 9593750.
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