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Eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
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| PDB rendering based on 1kl9. The Protein Data Bank ( PDB) is a repository for 3-D structural data of Proteins and Nucleic acids These data typically obtained by X-ray crystallography | ||
| Available structures: 1kl9, 1q8k | ||
| Identifiers | ||
| Symbol(s) | EIF2S1; EIF-2; EIF-2A; EIF-2alpha; EIF2; EIF2A | |
| External IDs | OMIM: 603907 MGI: 95299 HomoloGene: 3020 | |
| RNA expression pattern | ||
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| Orthologs | ||
| Human | Mouse | |
| Entrez | 1965 | 13665 |
| Ensembl | ENSG00000134001 | n/a |
| Uniprot | P05198 | n/a |
| Refseq | NM_004094 (mRNA) NP_004085 (protein) |
NM_026114 (mRNA) NP_080390 (protein) |
| Location | Chr 14: 66.9 - 66.92 Mb | n/a |
| Pubmed search | [1] | [2] |
Eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa, also known as EIF2S1, is a human gene. The Human Genome Organisation (HUGO is an organization involved in the Human Genome Project, a project about mapping the human genome The Mouse Genome Informatics (MGI website is run by The Jackson Laboratory. HomoloGene, a tool of the National Center for Biotechnology Information (NCBI is a system for automated detection of homologs (similarity attributable to descent The Entrez Global Query Cross-Database Search System is a powerful Federated search engine or Web portal that allows users to search many discrete Health sciences Ensembl is a joint scientific project between the European Bioinformatics Institute and the Wellcome Trust Sanger Institute, which was launched in 1999 in response to the imminent UniProt is the uni versal prot ein resource a central repository of Protein data created by combining Swiss-Prot, TrEMBL PubMed is a free search engine for accessing the MEDLINE database of citations and abstracts of biomedical research articles History See also History of genetics The existence of genes was first suggested by Gregor Mendel (1822-1884 who in the 1860s studied inheritance [1]
The translation initiation factor eIF2 catalyzes the first regulated step of protein synthesis initiation, promoting the binding of the initiator tRNA to 40S ribosomal subunits. Binding occurs as a ternary complex of methionyl-tRNA, eIF2, and GTP. eIF2 is composed of 3 nonidentical subunits, alpha (36 kD), beta (38 kD, MIM 603908), and gamma (52 kD, MIM 300161). The rate of formation of the ternary complex is modulated by the phosphorylation state of eIF2-alpha (Ernst et al. , 1987). [supplied by OMIM][1]
References
Further reading
- Hershey JW (1991). "Translational control in mammalian cells. ". Annu. Rev. Biochem. 60: 717–55. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 1883206.
- Mao X, Green JM, Safer B, et al. (1992). "Regulation of translation initiation factor gene expression during human T cell activation. ". J. Biol. Chem. 267 (28): 20444–50. PMID 1400363.
- Mellor H, Proud CG (1991). "A synthetic peptide substrate for initiation factor-2 kinases. ". Biochem. Biophys. Res. Commun. 178 (2): 430–7. PMID 1677563.
- Green SR, Spalding A, Ashford T, et al. (1992). "Synthesis of human initiation factor-2 alpha in Saccharomyces cerevisiae. ". Gene 108 (2): 253–8. PMID 1748310.
- Kramer G (1990). "Two phosphorylation sites on eIF-2 alpha. ". FEBS Lett. 267 (2): 181–2. PMID 2116318.
- Ernst H, Duncan RF, Hershey JW (1987). "Cloning and sequencing of complementary DNAs encoding the alpha-subunit of translational initiation factor eIF-2. Characterization of the protein and its messenger RNA. ". J. Biol. Chem. 262 (3): 1206–12. PMID 2948954.
- Kato S, Sekine S, Oh SW, et al. (1995). "Construction of a human full-length cDNA bank. ". Gene 150 (2): 243–50. PMID 7821789.
- Ray MK, Chakraborty A, Datta B, et al. (1993). "Characteristics of the eukaryotic initiation factor 2 associated 67-kDa polypeptide. ". Biochemistry 32 (19): 5151–9. PMID 8098621.
- Dever TE, Chen JJ, Barber GN, et al. (1993). "Mammalian eukaryotic initiation factor 2 alpha kinases functionally substitute for GCN2 protein kinase in the GCN4 translational control mechanism of yeast. ". Proc. Natl. Acad. Sci. U. S. A. 90 (10): 4616–20. PMID 8099443.
- Barber GN, Wambach M, Wong ML, et al. (1993). "Translational regulation by the interferon-induced double-stranded-RNA-activated 68-kDa protein kinase. ". Proc. Natl. Acad. Sci. U. S. A. 90 (10): 4621–5. PMID 8099444.
- Miyamoto S, Chiorini JA, Urcelay E, Safer B (1996). "Regulation of gene expression for translation initiation factor eIF-2 alpha: importance of the 3' untranslated region. ". Biochem. J. 315 ( Pt 3): 791–8. PMID 8645159.
- Yang W, Hinnebusch AG (1996). "Identification of a regulatory subcomplex in the guanine nucleotide exchange factor eIF2B that mediates inhibition by phosphorylated eIF2. ". Mol. Cell. Biol. 16 (11): 6603–16. PMID 8887689.
- Brand SR, Kobayashi R, Mathews MB (1997). "The Tat protein of human immunodeficiency virus type 1 is a substrate and inhibitor of the interferon-induced, virally activated protein kinase, PKR. ". J. Biol. Chem. 272 (13): 8388–95. PMID 9079663.
- Ting NS, Kao PN, Chan DW, et al. (1998). "DNA-dependent protein kinase interacts with antigen receptor response element binding proteins NF90 and NF45. ". J. Biol. Chem. 273 (4): 2136–45. PMID 9442054.
- Kimball SR, Heinzinger NK, Horetsky RL, Jefferson LS (1998). "Identification of interprotein interactions between the subunits of eukaryotic initiation factors eIF2 and eIF2B. ". J. Biol. Chem. 273 (5): 3039–44. PMID 9446619.
- Shi Y, Vattem KM, Sood R, et al. (1998). "Identification and characterization of pancreatic eukaryotic initiation factor 2 alpha-subunit kinase, PEK, involved in translational control. ". Mol. Cell. Biol. 18 (12): 7499–509. PMID 9819435.
- Satoh S, Hijikata M, Handa H, Shimotohno K (1999). "Caspase-mediated cleavage of eukaryotic translation initiation factor subunit 2alpha. ". Biochem. J. 342 ( Pt 1): 65–70. PMID 10432301.
- Berlanga JJ, Santoyo J, De Haro C (1999). "Characterization of a mammalian homolog of the GCN2 eukaryotic initiation factor 2alpha kinase. ". Eur. J. Biochem. 265 (2): 754–62. PMID 10504407.
- Lu J, O'Hara EB, Trieselmann BA, et al. (1999). "The interferon-induced double-stranded RNA-activated protein kinase PKR will phosphorylate serine, threonine, or tyrosine at residue 51 in eukaryotic initiation factor 2alpha. ". J. Biol. Chem. 274 (45): 32198–203. PMID 10542257.
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