EDSS can refer to:
- Elmira District Secondary School, the high school serving the town of Elmira, Ontario, Canada and the surrounding area. Elmira District Secondary School (EDSS is the high school serving the town of Elmira Ontario, Canada and the surrounding area The town of Elmira in Ontario, Canada is the largest community within the Township of Woolwich in the Regional Municipality of Waterloo and is Country to "Dominion of Canada" or "Canadian Federation" or anything else please read the Talk Page
- Expanded Disability Status Scale, a medical scale to monitor the disability changes in multiple sclerosis. The Kurtzke Expanded Disability Status Scale (EDSS is a method of quantifying disability in Multiple sclerosis. Multiple sclerosis (abbreviated MS also known as disseminated sclerosis or encephalomyelitis disseminata) is an autoimmune condition in which the
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