| Dorsal root ganglion | |
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| This is a dorsal root ganglion (DRG) from a chicken embryo (around stage of day 7) after incubation overnight in NGF growth medium stained with anti-neurofilament antibody. An embryo (from Greek:, plural, lit "that which grows" from en- "in" + bryein "to swell be full" is a multicellular Nerve growth factor ( NGF) is a small secreted Protein which induces the differentiation and survival of particular target Neurons (nerve Neurofilaments are the 10 nanometer (10nm or Intermediate filaments found specifically in neurons Antibodies (also known as immunoglobulins, abbreviated Ig) are Gamma globulin Proteins that are found in Blood or other Bodily Axons growing out of the ganglion are visible. | |
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| A spinal nerve with its anterior and posterior roots. The dorsal root ganglion is the "spinal ganglion", following the posterior/dorsal root. | |
| Latin | g. Latin ( lingua Latīna, laˈtiːna is an Italic language, historically spoken in Latium and Ancient Rome. sensorium nervi spinalis |
| Gray's | subject #185 750 |
| Precursor | neural crest |
| MeSH | Spinal+Ganglia |
| Dorlands/Elsevier | g_02/12384883 |
In anatomy and neurology, the dorsal root ganglion (or spinal ganglion) is a nodule on a dorsal root that contains cell bodies of neurons in afferent spinal nerves. This is a list of the subjects in Gray's Anatomy: IX Neurology Embryology (from Greek grc ἔμβρυον embryon, "unborn embryo" and grc -λογία -logia) is the study of the development The neural crest, a transient component of the Ectoderm, is located in between the Neural tube and the epidermis (or the free margins of the Neural folds Medical Subject Headings ( MeSH) is a huge Controlled vocabulary (or metadata system for the purpose of indexing journal articles and books Elsevier, the world's largest Publisher of Medical and Scientific literature, forms part of the Reed Elsevier group Anatomy (from the Greek anatomia, from ana separate apart from and temnein, to cut up cut open is a branch of Biology that is the consideration In Anatomy, a ganglion (pl ganglia) is a tissue mass. Neurology In neurological contexts ganglia are composed mainly of In Anatomy and Neurology, the dorsal root (or posterior root) is the afferent sensory root of a Spinal nerve. Neurons (ˈnjuːɹɒn also known as neurones and nerve cells) are responsive cells in the Nervous system that process and transmit information In the Nervous system, afferent neurons --otherwise known as sensory or receptor Neurons -carry nerve impulses from receptors or sense The term spinal nerve generally refers to the mixed spinal Nerve, which is formed from the dorsal and ventral roots that come out of the Spinal cord.
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Unique unipolar structure
The axons of dorsal root ganglion neurons are known as afferents. An axon or nerve fiber is a long slender projectionof a nerve cell or Neuron, that conducts electrical impulses away from the neuron's Cell Afferent is an Anatomical term with the following meanings Conveying towards a center for example the Afferent arterioles conveying blood In the peripheral nervous system, afferents refer to the axons that relay sensory information into the central nervous system and spinal cord. The peripheral nervous system ( PNS) resides or extends outside the Central nervous system (CNS which consists of the Brain and Spinal cord. In Vertebrates the central nervous system ( CNS) is the part of the Nervous system which is enclosed in the Meninges. The spinal cord is a long thin tubular bundle of Nerves that is an extension of the Central nervous system from the brain and is enclosed in and protected These neurons are of the pseudo-unipolar type, meaning they have an axon with two branches that act as a single axon, often referred to as a distal process and a proximal process. A pseudounipolar neuron ( pseudo - false uni - one is a sensory Neuron in the Peripheral nervous system.
Unlike the majority of neurons found in the central nervous system, an action potential in dorsal root ganglion neuron may initiate in the distal process in the periphery, bypass the cell body, and continue to propagate along the proximal process until reaching the synaptic terminal in the dorsal horn of the spinal cord. In Vertebrates the central nervous system ( CNS) is the part of the Nervous system which is enclosed in the Meninges. In Neurophysiology, the action potential is a self-regenerating Wave of Electrochemical activity that allows Nerve cells to carry a signal Chemical synapses are specialized junctions through which Neurons signal to each other and to non-neuronal cells such as those in Muscles or Glands
Distal section
The distal section of the axon may either be a bare nerve ending or encapsulated by a structure that helps relay specific information to nerve. For example, a Meissner's corpuscle or Pacinian corpuscle may encapsulate the nerve ending, rendering the distal process sensitive to mechanical stimulation, such as stroking or vibration, respectively. Meissner's corpuscles (or tactile corpuscles) are a type of Mechanoreceptor. Pacinian corpuscles are one of the four major types of Mechanoreceptor. [1]
Location
The dorsal root ganglia lie along the vertebral columna by the spine.
Embryology
The dorsal root ganglia develops in the embryo from neural crest cells. The neural crest, a transient component of the Ectoderm, is located in between the Neural tube and the epidermis (or the free margins of the Neural folds
Nociception
G protein-coupled receptor on the DRG have been associated with nociception. G protein-coupled receptors ( GPCRs) also known as seven transmembrane domain receptors, 7TM receptors, heptahelical receptors, and Nociception (synonym nociperception is defined as "the neural processes of encoding and processing Noxious stimuli. [2]
References
- ^ Kandel ER, Schwartz JH, Jessell TM. Eric Richard Kandel (born November 7, 1929) is a Psychiatrist, a neuroscientist and Professor of Biochemistry Principles of Neural Science, 4th ed. First published in 1981 by Elsevier, Principles of Neural Science is a Neuroscience Textbook edited by Eric R , p. 431-433. McGraw-Hill, New York (2000). ISBN 0-8385-7701-6
- ^ Huang CW, Tzeng JN, Chen YJ, Tsai WF, Chen CC, Sun WH (2007). "Nociceptors of dorsal root ganglion express proton-sensing G-protein-coupled receptors". Mol. Cell. Neurosci. 36 (2): 195–210. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 17720533.
See also
Additional images
 Medulla spinalis |
 The formation of the spinal nerve from the dorsal and ventral roots | |
 Scheme showing structure of a typical spinal nerve. In Anatomy and Neurology, the ventral root (or anterior root) is the efferent motor root of a Spinal nerve. |
External links
- SUNY Figs 02:04-09
- Histology at BU 04401loa
- Photo of model at Ohio State University
- Diagram at webanatomy. The State University of New York Health Science Center at Brooklyn, better known as SUNY Downstate Medical Center, is an academic medical center and is the only one of its kind For similarly-named academic institutions see Education in Boston MA. The Ohio State University ( OSU) is a Coeducational public Research university in the state of Ohio. net
- Photo at uwlax. edu
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