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Dipeptidyl-peptidase 4 (CD26, adenosine deaminase complexing protein 2)
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| Ribbon diagram of human DPP-4. Proteins are an important class of biological Macromolecules present in all biological organisms made up of such elements as Carbon, Hydrogen From PDB 1PFQ. The Protein Data Bank ( PDB) is a repository for 3-D structural data of Proteins and Nucleic acids These data typically obtained by X-ray crystallography |
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| Available structures: 1j2e, 1n1m, 1nu6, 1nu8, 1pfq, 1r9m, 1r9n, 1rwq, 1tk3, 1tkr, 1u8e, 1w1i, 1wcy, 1x70, 2ajl, 2bgn, 2bgr, 2bub, 2fjp, 2g5p, 2g5t, 2g63, 2hha, 2i03, 2iit, 2iiv, 2ogz, 2oph, 2oqi, 2oqv, 2p8s | ||
| Identifiers | ||
| Symbol(s) | DPP4; ADABP; ADCP2; CD26; DPPIV; TP103 | |
| External IDs | OMIM: 102720 MGI: 94919 HomoloGene: 3279 | |
| RNA expression pattern | ||
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| Orthologs | ||
| Human | Mouse | |
| Entrez | 1803 | 13482 |
| Ensembl | ENSG00000197635 | ENSMUSG00000035000 |
| Uniprot | P27487 | Q3TR43 |
| Refseq | NM_001935 (mRNA) NP_001926 (protein) |
NM_010074 (mRNA) NP_034204 (protein) |
| Location | Chr 2: 162.56 - 162.64 Mb | Chr 2: 62.13 - 62.21 Mb |
| Pubmed search | [1] | [2] |
The enzyme DPP-4 also part of the CD26 surface region is associated with immune regulation, signal transduction and apoptosis. The Human Genome Organisation (HUGO is an organization involved in the Human Genome Project, a project about mapping the human genome The Mouse Genome Informatics (MGI website is run by The Jackson Laboratory. HomoloGene, a tool of the National Center for Biotechnology Information (NCBI is a system for automated detection of homologs (similarity attributable to descent The Entrez Global Query Cross-Database Search System is a powerful Federated search engine or Web portal that allows users to search many discrete Health sciences Ensembl is a joint scientific project between the European Bioinformatics Institute and the Wellcome Trust Sanger Institute, which was launched in 1999 in response to the imminent UniProt is the uni versal prot ein resource a central repository of Protein data created by combining Swiss-Prot, TrEMBL PubMed is a free search engine for accessing the MEDLINE database of citations and abstracts of biomedical research articles Enzymes are Biomolecules that catalyze ( ie increase the rates of Chemical reactions Almost all enzymes are Proteins The cluster of differentiation (often abbreviated as CD) is a protocol used for the identification and investigation of Cell surface molecules present on Leukocytes In Biology, signal transduction refers to any process by which a cell converts one kind of signal or stimulus into another It is a rather indiscriminate enzyme for which at least 62 substrates are known. [1] Furthermore it appears to work as a suppressor in the development of cancer and tumours. Cancer (medical term Malignant Neoplasm) is a class of Diseases in which a group of cells display uncontrolled See also Cancer A tumor or tumour is the name for a swelling or lesion formed by an abnormal growth of cells (termed neoplastic [2] Dipeptidyl peptidase-4 plays a major role in glucose metabolism. Glucose (Glc a Monosaccharide (or simple Sugar) also known as grape sugar, is an important Carbohydrate in Biology. It is responsible for the degradation of incretins such as GLP-1. Incretins are a type of gastrointestinal hormone that cause an increase in the amount of Insulin released from the Beta cells of the Glucagon-like peptide-1 (GLP-1 is derived from the transcription product of the Proglucagon gene DPP-4 also binds the enzyme adenosine deaminase specifically and with high affinity. The significance of this interaction has yet to be established.
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Clinical significance
A new class of oral hypoglycemics called dipeptidyl peptidase-4 inhibitors work by inhibiting the action of this enzyme, thereby prolonging incretin effect in vivo. Anti-diabetic drugs treat Diabetes mellitus by lowering Glucose levels in the blood Inhibitors of Dipeptidyl peptidase 4, also DPP-4 inhibitors, are a new class of Oral hypoglycemics which block DPP-4
References
- ^ Merck's March Madness - Forbes.com
- ^ Pro B, Dang N (2004). "CD26/dipeptidyl peptidase IV and its role in cancer". Histol Histopathol 19 (4): 1345–51. PMID 15375776.
Masur K et al. (2006). "DPPIV inhibitors extend GLP-2 mediated tumour promoting effects on intestinal cancer cells". Regul Pept. 137 (3): 147–55. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 16908079.
Wesley UV et al. (2005). "Dipeptidyl peptidase inhibits malignant phenotype of prostate cancer cells by blocking basic fibroblast growth factor signaling pathway". Cancer Res. 65 (4): 1325–34. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 15735018.
External links
Further reading
- Ansorge S, Bühling F, Kähne T, et al. Medical Subject Headings ( MeSH) is a huge Controlled vocabulary (or metadata system for the purpose of indexing journal articles and books This article is about the University of Toronto's St George Campus (1997). "CD26/dipeptidyl peptidase IV in lymphocyte growth regulation. ". Adv. Exp. Med. Biol. 421: 127–40. PMID 9330689.
- Reinhold D, Kähne T, Steinbrecher A, et al. (2003). "The role of dipeptidyl peptidase IV (DP IV) enzymatic activity in T cell activation and autoimmunity. ". Biol. Chem. 383 (7-8): 1133–8. PMID 12437097.
- Sato K, Dang NH (2003). "CD26: a novel treatment target for T-cell lymphoid malignancies? (Review). ". Int. J. Oncol. 22 (3): 481–97. PMID 12579300.
- de Meester I, Lambeir AM, Proost P, Scharpé S (2003). "Dipeptidyl peptidase IV substrates. An update on in vitro peptide hydrolysis by human DPPIV. ". Adv. Exp. Med. Biol. 524: 3–17. PMID 12675218.
- Koch S, Anthonsen D, Skovbjerg H, Sjöström H (2003). "On the role of dipeptidyl peptidase IV in the digestion of an immunodominant epitope in celiac disease. ". Adv. Exp. Med. Biol. 524: 181–7. PMID 12675238.
- Pro B, Dang NH (2005). "CD26/dipeptidyl peptidase IV and its role in cancer. ". Histol. Histopathol. 19 (4): 1345–51. PMID 15375776.