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Deoxycytidine kinase
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| PDB rendering based on 1p5z. The Protein Data Bank ( PDB) is a repository for 3-D structural data of Proteins and Nucleic acids These data typically obtained by X-ray crystallography | ||
| Available structures: 1p5z, 1p60, 1p61, 1p62, 2a2z, 2a30, 2a7q, 2no9, 2noa | ||
| Identifiers | ||
| Symbol(s) | DCK; MGC117410; MGC138632 | |
| External IDs | OMIM: 125450 MGI: 102726 HomoloGene: 616 | |
| EC number | 2.7.1.74 | |
| RNA expression pattern | ||
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| Orthologs | ||
| Human | Mouse | |
| Entrez | 1633 | 13178 |
| Ensembl | ENSG00000156136 | ENSMUSG00000029366 |
| Uniprot | P27707 | Q545E8 |
| Refseq | NM_000788 (mRNA) NP_000779 (protein) |
XM_977104 (mRNA) XP_982198 (protein) |
| Location | Chr 4: 72.08 - 72.12 Mb | Chr 5: 89.84 - 89.86 Mb |
| Pubmed search | [1] | [2] |
Deoxycytidine kinase, also known as DCK, is a human gene. The Human Genome Organisation (HUGO is an organization involved in the Human Genome Project, a project about mapping the human genome The Mouse Genome Informatics (MGI website is run by The Jackson Laboratory. HomoloGene, a tool of the National Center for Biotechnology Information (NCBI is a system for automated detection of homologs (similarity attributable to descent This article is about the Enzyme Commission codes For the European Commission system for coding chemicals see EC-No. The Entrez Global Query Cross-Database Search System is a powerful Federated search engine or Web portal that allows users to search many discrete Health sciences Ensembl is a joint scientific project between the European Bioinformatics Institute and the Wellcome Trust Sanger Institute, which was launched in 1999 in response to the imminent UniProt is the uni versal prot ein resource a central repository of Protein data created by combining Swiss-Prot, TrEMBL PubMed is a free search engine for accessing the MEDLINE database of citations and abstracts of biomedical research articles History See also History of genetics The existence of genes was first suggested by Gregor Mendel (1822-1884 who in the 1860s studied inheritance [1]
Deoxycytidine kinase is an enzyme which transfers phosphate to deoxycytidine. Enzymes are Biomolecules that catalyze ( ie increase the rates of Chemical reactions Almost all enzymes are Proteins Deoxycytidine is a Deoxyribonucleoside. It is like Cytidine, but with one Oxygen atom removed
Deoxycytidine kinase (DCK) is required for the phosphorylation of several deoxyribonucleosides and their nucleoside analogs. Deficiency of DCK is associated with resistance to antiviral and anticancer chemotherapeutic agents. Conversely, increased deoxycytidine kinase activity is associated with increased activation of these compounds to cytotoxic nucleoside triphosphate derivatives. DCK is clinically important because of its relationship to drug resistance and sensitivity. [1]
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References
Further reading
- Arnér ES, Eriksson S (1996). "Mammalian deoxyribonucleoside kinases. ". Pharmacol. Ther. 67 (2): 155–86. PMID 7494863.
- Chottiner EG, Shewach DS, Datta NS, et al. (1991). "Cloning and expression of human deoxycytidine kinase cDNA. ". Proc. Natl. Acad. Sci. U. S. A. 88 (4): 1531–5. PMID 1996353.
- Eriksson S, Cederlund E, Bergman T, et al. (1991). "Characterization of human deoxycytidine kinase. Correlation with cDNA sequences. ". FEBS Lett. 280 (2): 363–6. PMID 2013338.
- Yamada Y, Goto H, Ogasawara N (1984). "Purine nucleoside kinases in human T- and B-lymphoblasts. ". Biochim. Biophys. Acta 761 (1): 34–40. PMID 6315069.
- Hurley MC, Palella TD, Fox IH (1984). "Human placental deoxyadenosine and deoxyguanosine phosphorylating activity. ". J. Biol. Chem. 258 (24): 15021–7. PMID 6317685.
- Spasokoukotskaja T, Arnér ES, Brosjö O, et al. (1995). "Expression of deoxycytidine kinase and phosphorylation of 2-chlorodeoxyadenosine in human normal and tumour cells and tissues. ". Eur. J. Cancer 31A (2): 202–8. PMID 7718326.
- Stegmann AP, Honders MW, Bolk MW, et al. (1993). "Assignment of the human deoxycytidine kinase (DCK) gene to chromosome 4 band q13. 3-q21. 1. ". Genomics 17 (2): 528–9. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 8406512.
- Song JJ, Walker S, Chen E, et al. (1993). "Genomic structure and chromosomal localization of the human deoxycytidine kinase gene. ". Proc. Natl. Acad. Sci. U. S. A. 90 (2): 431–4. PMID 8421671.
- Johansson M, Brismar S, Karlsson A (1997). "Human deoxycytidine kinase is located in the cell nucleus. ". Proc. Natl. Acad. Sci. U. S. A. 94 (22): 11941–5. PMID 9342341.
- Hatzis P, Al-Madhoon AS, Jüllig M, et al. (1998). "The intracellular localization of deoxycytidine kinase. ". J. Biol. Chem. 273 (46): 30239–43. PMID 9804782.
- Saada A, Shaag A, Mandel H, et al. (2001). "Mutant mitochondrial thymidine kinase in mitochondrial DNA depletion myopathy. ". Nat. Genet. 29 (3): 342–4. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 11687801.
- Veuger MJ, Heemskerk MH, Honders MW, et al. (2002). "Functional role of alternatively spliced deoxycytidine kinase in sensitivity to cytarabine of acute myeloid leukemic cells. ". Blood 99 (4): 1373–80. PMID 11830489.
- Innoceta A, Galluzzi L, Ruzzo A, et al. (2002). "Molecular basis of 2',3'-dideoxycytidine-induced drug resistance in human cells. ". Mol. Cell. Biochem. 231 (1-2): 173–7. PMID 11952160.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. ". Proc. Natl. Acad. Sci. U. S. A. 99 (26): 16899–903. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 12477932.
- Krawiec K, Kierdaszuk B, Shugar D (2003). "Inorganic tripolyphosphate (PPP(i)) as a phosphate donor for human deoxyribonucleoside kinases. ". Biochem. Biophys. Res. Commun. 301 (1): 192–7. PMID 12535661.
- van der Wilt CL, Kroep JR, Loves WJ, et al. (2003). "Expression of deoxycytidine kinase in leukaemic cells compared with solid tumour cell lines, liver metastases and normal liver. ". Eur. J. Cancer 39 (5): 691–7. PMID 12628850.
- Ge Y, Jensen TL, Matherly LH, Taub JW (2004). "Physical and functional interactions between USF and Sp1 proteins regulate human deoxycytidine kinase promoter activity. ". J. Biol. Chem. 278 (50): 49901–10. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 14514691.
- Usova E, Maltseva T, Földesi A, et al. (2005). "Human deoxycytidine kinase as a deoxyribonucleoside phosphorylase. ". J. Mol. Biol. 344 (5): 1347–58. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 15561147.
- Mani RS, Usova EV, Eriksson S, Cass CE (2005). "Fluorescence studies of substrate binding to human recombinant deoxycytidine kinase. ". Nucleosides Nucleotides Nucleic Acids 23 (8-9): 1343–6. PMID 15571255.
See also
External links
Nucleoside phosphorylase, also known as NP, is a human Gene. Medical Subject Headings ( MeSH) is a huge Controlled vocabulary (or metadata system for the purpose of indexing journal articles and booksDapyx Software network: MP3 Explorer | Ebook Manager | Zenithic