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Dual specificity phosphatase 6
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| PDB rendering based on 1hzm. The Protein Data Bank ( PDB) is a repository for 3-D structural data of Proteins and Nucleic acids These data typically obtained by X-ray crystallography | ||
| Available structures: 1hzm, 1mkp | ||
| Identifiers | ||
| Symbol(s) | DUSP6; MKP3; PYST1 | |
| External IDs | OMIM: 602748 MGI: 1914853 HomoloGene: 55621 | |
| RNA expression pattern | ||
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| Orthologs | ||
| Human | Mouse | |
| Entrez | 1848 | 67603 |
| Ensembl | ENSG00000139318 | ENSMUSG00000019960 |
| Uniprot | Q16828 | Q3U786 |
| Refseq | NM_001946 (mRNA) NP_001937 (protein) |
NM_026268 (mRNA) NP_080544 (protein) |
| Location | Chr 12: 88.27 - 88.27 Mb | Chr 10: 98.69 - 98.7 Mb |
| Pubmed search | [1] | [2] |
Dual specificity phosphatase 6, also known as DUSP6, is a human gene. The Human Genome Organisation (HUGO is an organization involved in the Human Genome Project, a project about mapping the human genome The Mouse Genome Informatics (MGI website is run by The Jackson Laboratory. HomoloGene, a tool of the National Center for Biotechnology Information (NCBI is a system for automated detection of homologs (similarity attributable to descent The Entrez Global Query Cross-Database Search System is a powerful Federated search engine or Web portal that allows users to search many discrete Health sciences Ensembl is a joint scientific project between the European Bioinformatics Institute and the Wellcome Trust Sanger Institute, which was launched in 1999 in response to the imminent UniProt is the uni versal prot ein resource a central repository of Protein data created by combining Swiss-Prot, TrEMBL PubMed is a free search engine for accessing the MEDLINE database of citations and abstracts of biomedical research articles History See also History of genetics The existence of genes was first suggested by Gregor Mendel (1822-1884 who in the 1860s studied inheritance [1]
The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK2, is expressed in a variety of tissues with the highest levels in heart and pancreas, and unlike most other members of this family, is localized in the cytoplasm. Two transcript variants encoding different isoforms have been found for this gene. [1]
References
Further reading
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. ". Gene 138 (1-2): 171-4. PMID 8125298.
- Muda M, Boschert U, Dickinson R, et al. (1996). "MKP-3, a novel cytosolic protein-tyrosine phosphatase that exemplifies a new class of mitogen-activated protein kinase phosphatase. ". J. Biol. Chem. 271 (8): 4319-26. PMID 8626780.
- Groom LA, Sneddon AA, Alessi DR, et al. (1996). "Differential regulation of the MAP, SAP and RK/p38 kinases by Pyst1, a novel cytosolic dual-specificity phosphatase. ". EMBO J. 15 (14): 3621-32. PMID 8670865.
- Smith A, Price C, Cullen M, et al. (1997). "Chromosomal localization of three human dual specificity phosphatase genes (DUSP4, DUSP6, and DUSP7). ". Genomics 42 (3): 524-7. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 9205128.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. ". Gene 200 (1-2): 149-56. PMID 9373149.
- Muda M, Theodosiou A, Gillieron C, et al. (1998). "The mitogen-activated protein kinase phosphatase-3 N-terminal noncatalytic region is responsible for tight substrate binding and enzymatic specificity. ". J. Biol. Chem. 273 (15): 9323-9. PMID 9535927.
- Furukawa T, Yatsuoka T, Youssef EM, et al. (1999). "Genomic analysis of DUSP6, a dual specificity MAP kinase phosphatase, in pancreatic cancer. ". Cytogenet. Cell Genet. 82 (3-4): 156-9. PMID 9858808.
- Stewart AE, Dowd S, Keyse SM, McDonald NQ (1999). "Crystal structure of the MAPK phosphatase Pyst1 catalytic domain and implications for regulated activation. ". Nat. Struct. Biol. 6 (2): 174-81. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 10048930.
- Rössig L, Hermann C, Haendeler J, et al. (2002). "Angiotensin II-induced upregulation of MAP kinase phosphatase-3 mRNA levels mediates endothelial cell apoptosis. ". Basic Res. Cardiol. 97 (1): 1-8. PMID 11998972.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. ". Proc. Natl. Acad. Sci. U. S. A. 99 (26): 16899-903. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 12477932.
- Furukawa T, Sunamura M, Motoi F, et al. (2003). "Potential tumor suppressive pathway involving DUSP6/MKP-3 in pancreatic cancer. ". Am. J. Pathol. 162 (6): 1807-15. PMID 12759238.
- Kim HS, Song MC, Kwak IH, et al. (2003). "Constitutive induction of p-Erk1/2 accompanied by reduced activities of protein phosphatases 1 and 2A and MKP3 due to reactive oxygen species during cellular senescence. ". J. Biol. Chem. 278 (39): 37497-510. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 12840032.
- Kim Y, Rice AE, Denu JM (2004). "Intramolecular dephosphorylation of ERK by MKP3. ". Biochemistry 42 (51): 15197-207. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 14690430.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs. ". Nat. Genet. 36 (1): 40-5. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 14702039.
- Karlsson M, Mathers J, Dickinson RJ, et al. (2004). "Both nuclear-cytoplasmic shuttling of the dual specificity phosphatase MKP-3 and its ability to anchor MAP kinase in the cytoplasm are mediated by a conserved nuclear export signal. ". J. Biol. Chem. 279 (40): 41882-91. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 15269220.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). ". Genome Res. 14 (10B): 2121-7. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 15489334.
- Marchetti S, Gimond C, Chambard JC, et al. (2005). "Extracellular signal-regulated kinases phosphorylate mitogen-activated protein kinase phosphatase 3/DUSP6 at serines 159 and 197, two sites critical for its proteasomal degradation. ". Mol. Cell. Biol. 25 (2): 854-64. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 15632084.
- Kamata H, Honda S, Maeda S, et al. (2005). "Reactive oxygen species promote TNFalpha-induced death and sustained JNK activation by inhibiting MAP kinase phosphatases. ". Cell 120 (5): 649-61. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 15766528.
- Xu S, Furukawa T, Kanai N, et al. (2005). "Abrogation of DUSP6 by hypermethylation in human pancreatic cancer. ". J. Hum. Genet. 50 (4): 159-67. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 15824892.
- Furukawa T, Fujisaki R, Yoshida Y, et al. (2005). "Distinct progression pathways involving the dysfunction of DUSP6/MKP-3 in pancreatic intraepithelial neoplasia and intraductal papillary-mucinous neoplasms of the pancreas. ". Mod. Pathol. 18 (8): 1034-42. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 15832194.
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