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Dynamin 1
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| PDB rendering based on 1dyn. The Protein Data Bank ( PDB) is a repository for 3-D structural data of Proteins and Nucleic acids These data typically obtained by X-ray crystallography | ||
| Available structures: 1dyn, 2aka, 2dyn | ||
| Identifiers | ||
| Symbol(s) | DNM1; DNM | |
| External IDs | OMIM: 602377 MGI: 107384 HomoloGene: 68397 | |
| RNA expression pattern | ||
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| Orthologs | ||
| Human | Mouse | |
| Entrez | 1759 | 13429 |
| Ensembl | ENSG00000106976 | ENSMUSG00000026825 |
| Uniprot | Q05193 | Q6PDM5 |
| Refseq | NM_001005336 (mRNA) NP_001005336 (protein) |
NM_010065 (mRNA) NP_034195 (protein) |
| Location | Chr 9: 130.01 - 130.06 Mb | Chr 2: 32.13 - 32.18 Mb |
| Pubmed search | [1] | [2] |
Dynamin 1, also known as DNM1, is a human gene. The Human Genome Organisation (HUGO is an organization involved in the Human Genome Project, a project about mapping the human genome The Mouse Genome Informatics (MGI website is run by The Jackson Laboratory. HomoloGene, a tool of the National Center for Biotechnology Information (NCBI is a system for automated detection of homologs (similarity attributable to descent The Entrez Global Query Cross-Database Search System is a powerful Federated search engine or Web portal that allows users to search many discrete Health sciences Ensembl is a joint scientific project between the European Bioinformatics Institute and the Wellcome Trust Sanger Institute, which was launched in 1999 in response to the imminent UniProt is the uni versal prot ein resource a central repository of Protein data created by combining Swiss-Prot, TrEMBL PubMed is a free search engine for accessing the MEDLINE database of citations and abstracts of biomedical research articles History See also History of genetics The existence of genes was first suggested by Gregor Mendel (1822-1884 who in the 1860s studied inheritance
This gene encodes a member of the dynamin subfamily of GTP-binding proteins. The encoded protein possesses unique mechanochemical properties used to tubulate and sever membranes, and is involved in clathrin-mediated endocytosis and other vesicular trafficking processes. Actin and other cytoskeletal proteins act as binding partners for the encoded protein, which can also self-assemble leading to stimulation of GTPase activity. More than sixty highly conserved copies of the 3' region of this gene are found elsewhere in the genome, particularly on chromosomes Y and 15. Alternatively spliced transcript variants encoding different isoforms have been described. [1]
References
Further reading
- Sever S (2003). "Dynamin and endocytosis. ". Curr. Opin. Cell Biol. 14 (4): 463-7. PMID 12383797.
- Wiejak J, Wyroba E (2003). "Dynamin: characteristics, mechanism of action and function. ". Cell. Mol. Biol. Lett. 7 (4): 1073-80. PMID 12511974.
- Orth JD, McNiven MA (2003). "Dynamin at the actin-membrane interface. ". Curr. Opin. Cell Biol. 15 (1): 31-9. PMID 12517701.
- Obar RA, Collins CA, Hammarback JA, et al. (1990). "Molecular cloning of the microtubule-associated mechanochemical enzyme dynamin reveals homology with a new family of GTP-binding proteins. ". Nature 347 (6290): 256-61. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 2144893.
- Timm D, Salim K, Gout I, et al. (1995). "Crystal structure of the pleckstrin homology domain from dynamin. ". Nat. Struct. Biol. 1 (11): 782-8. PMID 7634088.
- Downing AK, Driscoll PC, Gout I, et al. (1995). "Three-dimensional solution structure of the pleckstrin homology domain from dynamin. ". Curr. Biol. 4 (10): 884-91. PMID 7850421.
- Ferguson KM, Lemmon MA, Schlessinger J, Sigler PB (1994). "Crystal structure at 2. 2 A resolution of the pleckstrin homology domain from human dynamin. ". Cell 79 (2): 199-209. PMID 7954789.
- van der Bliek AM, Redelmeier TE, Damke H, et al. (1993). "Mutations in human dynamin block an intermediate stage in coated vesicle formation. ". J. Cell Biol. 122 (3): 553-63. PMID 8101525.
- Miki H, Miura K, Matuoka K, et al. (1994). "Association of Ash/Grb-2 with dynamin through the Src homology 3 domain. ". J. Biol. Chem. 269 (8): 5489-92. PMID 8119878.
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. ". Gene 138 (1-2): 171-4. PMID 8125298.
- Sontag JM, Fykse EM, Ushkaryov Y, et al. (1994). "Differential expression and regulation of multiple dynamins. ". J. Biol. Chem. 269 (6): 4547-54. PMID 8308025.
- Newman-Smith ED, Shurland DL, van der Bliek AM (1997). "Assignment of the dynamin-1 gene (DNM1) to human chromosome 9q34 by fluorescence in situ hybridization and somatic cell hybrid analysis. ". Genomics 41 (2): 286-9. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 9143509.
- Grabs D, Slepnev VI, Songyang Z, et al. (1997). "The SH3 domain of amphiphysin binds the proline-rich domain of dynamin at a single site that defines a new SH3 binding consensus sequence. ". J. Biol. Chem. 272 (20): 13419-25. PMID 9148966.
- Ramjaun AR, Micheva KD, Bouchelet I, McPherson PS (1997). "Identification and characterization of a nerve terminal-enriched amphiphysin isoform. ". J. Biol. Chem. 272 (26): 16700-6. PMID 9195986.
- Ringstad N, Nemoto Y, De Camilli P (1997). "The SH3p4/Sh3p8/SH3p13 protein family: binding partners for synaptojanin and dynamin via a Grb2-like Src homology 3 domain. ". Proc. Natl. Acad. Sci. U. S. A. 94 (16): 8569-74. PMID 9238017.
- McMahon HT, Wigge P, Smith C (1997). "Clathrin interacts specifically with amphiphysin and is displaced by dynamin. ". FEBS Lett. 413 (2): 319-22. PMID 9280305.
- Wigge P, Köhler K, Vallis Y, et al. (1997). "Amphiphysin heterodimers: potential role in clathrin-mediated endocytosis. ". Mol. Biol. Cell 8 (10): 2003-15. PMID 9348539.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. ". Gene 200 (1-2): 149-56. PMID 9373149.
- Witke W, Podtelejnikov AV, Di Nardo A, et al. (1998). "In mouse brain profilin I and profilin II associate with regulators of the endocytic pathway and actin assembly. ". EMBO J. 17 (4): 967-76. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 9463375.
- Slepnev VI, Ochoa GC, Butler MH, et al. (1998). "Role of phosphorylation in regulation of the assembly of endocytic coat complexes. ". Science 281 (5378): 821-4. PMID 9694653.
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