D2X may be:

• Nikon D2X, a camera manufactured by Nikon
• D2X (source port), an open source port of the game Descent II
• Diablo II: Lord of Destruction, the expansion to Diablo II

The Nikon D2X is a 124- Megapixel professional Digital single-lens reflex camera that Nikon Corporation announced on September 16, Descent II is a 3D First-person shooter Video game noted for popularizing the use of true 3D rendering technology and providing the Diablo II Lord of Destruction (commonly abbreviated LoD) is an Expansion pack for the Hack and slash Action role-playing

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