 |
|
|
Cyproheptadine
|
|
| Systematic (IUPAC) name | |
| 4-(5 H-dibenzo [a,d]cyclohepten-5-ylidene)- 1 -methylpiperidine hydrochloride | |
| Identifiers | |
| CAS number | |
| ATC code | R06 |
| PubChem | |
| DrugBank | |
| Chemical data | |
| Formula | C21H21N |
| Mol. mass | 287. IUPAC Nomenclature is a system of naming Chemical compounds and of describing the science of Chemistry in general CAS registry numbers are unique numerical identifiers for Chemical compounds Polymers biological sequences mixtures and Alloys They are also referred to The Anatomical Therapeutic Chemical Classification System is used for the classification of drugs It is controlled by the WHO Collaborating Centre for Drug A section of the Anatomical Therapeutic Chemical Classification System. PubChem is a Database of chemical Molecules The system is maintained by the National Center for Biotechnology Information (NCBI a component The DrugBank database available at the University of Alberta is a unique Bioinformatics and Cheminformatics resource that combines detailed drug (i A chemical formula is a way of expressing information about the Atoms that constitute a particular Chemical compound, and how the relationship between those atoms changes Carbon (kɑɹbən is a Chemical element with the symbol C and its Atomic number is 6 Hydrogen (ˈhaɪdrədʒən is the Chemical element with Atomic number 1 Nitrogen (ˈnaɪtɹəʤɪn is a Chemical element that has the symbol N and Atomic number 7 and Atomic weight 14 The molecular mass (abbreviated m of a substance, more commonly referred to as molecular weight and abbreviated as MW, is the Mass of one 398 g/mol |
| Pharmacokinetic data | |
| Bioavailability | ? |
| Protein binding | 96 to 99% |
| Metabolism | Hepatic and renal |
| Half life | 1 to 4 hours |
| Excretion | Fecal and renal |
| Therapeutic considerations | |
| Pregnancy cat. |
B(US) |
| Legal status |
P(UK) |
| Routes | Oral only |
Cyproheptadine (usually as cyproheptadine hydrochloride, trade name Periactin) is an antihistaminic and antiserotonergic agent. In Pharmacology, bioavailability is used to describe the fraction of an administered Dose of unchanged drug that reaches the Systemic circulation, one of A drug's efficiency may be affected by the degree to which it binds to the proteins within Blood plasma. Drug metabolism is the Metabolism of drugs, their Biochemical modification or degradation usually through specialized enzymatic systems The liver is a vital organ in the human body and is present in Vertebrates and some other animals The kidneys are complicated organs that have numerous biological roles The biological half-life of a substance is the time it takes for a substance (drug radioactive nuclide or other to lose half of its pharmacologic physiologic or radiologic activity Excretion is the process of eliminating waste products of Metabolism and other non-useful materials The pregnancy category of a pharmaceutical agent is an assessment of the risk of fetal injury due to the pharmaceutical if it is used as directed by the mother during The United States of America —commonly referred to as the The regulation of therapeutic goods, that is drugs and therapeutic devices, varies by jurisdiction The United Kingdom of Great Britain and Northern Ireland, commonly known as the United Kingdom, the UK or Britain,is a Sovereign state located In Pharmacology and Toxicology, a route A histamine antagonist is an agent which serves to inhibit the release or action of Histamine. It acts as a 5-HT2 receptor antagonist and also blocks calcium channels. In the field of Neurochemistry, 5-HT receptors are receptors for the Neurotransmitter and peripheral signal mediator Serotonin, also A receptor antagonist is a type of receptor ligand or Drug that does not provoke a biological response itself upon binding to a receptor, but blocks A Calcium channel is an Ion channel which displays selective permeabiltiy to Calcium ions
Uses
Cyproheptadine is used in the treatment of allergies (specifically hay fever) and is also used to stimulate appetite in underweight people (e. Hay Fever is a comic play written by Noel Coward in 1924 and first produced in 1925 with Marie Tempest as the first Judith Bliss g. anorexia nervosa). Anorexia Nervosa is a psychiatric Diagnosis that describes an Eating disorder characterized by low Body weight and Body image distortion
Cyproheptadine is used in serotonin syndrome, a complex of symptoms associated with selective serotonin reuptake inhibitors, especially when taken in excess dose, meperidine and in the disease carcinoid in which serotonin is overproduced by tumor cells. Serotonin syndrome is a potentially life-threatening adverse drug reaction that may occur following therapeutic drug use inadvertent interactions between drugs or the recreational Selective serotonin reuptake inhibitors ( SSRIs) are a class of Antidepressants used in the treatment of depression, Anxiety disorders Pethidine ( INN) or meperidine ( USAN) (commonly referred to as Demerol but also referred to as isonipecaine lidol pethanol piridosal Algil Alodan Carcinoid (also carcinoid tumour or carcinoid tumor) is a slow-growing but Malignant type of Neuroendocrine tumour, originating in the cells
Cyproheptadine is a useful alternative to benzodiazepine hypnotics in the treatment of insomnia. The benzodiazepines (pronounced, often abbreviated to "benzos") are a class of Psychoactive drugs with varying Hypnotic Cyproheptadine may be superior to benzodiazepines in the treatment of insomnia because cyproheptadine enhances sleep quality and quantity whereas benzodiazepines tend to decrease sleep quality. [1]
Recently, Cyproheptadine has also been prescribed to children and adolescents with frequent migranes.
Side effects
While not specifically used as a sedative, cyproheptadine causes sedation, likely due to its anti-histamine effects. A sedative, or more specifically a sedative-hypnotic, is a substance that depresses the Central nervous system (CNS resulting in calmness relaxation sleepiness
Digestive system: epigastric distress (dysphagia), loss of appetite, nausea, vomiting, (it is noted that these side effects are much more common in people with neuromuscular disorders)
Cyproheptadine can also cause Over Sleeping(10 Hours)in Children and Adolescents.
References
- ^ Tokunaga S; Takeda Y, Shinomiya K, Hirase M, Kamei C. (Feb 2007). "Effects of some H1-antagonists on the sleep-wake cycle in sleep-disturbed rats." (pdf). J Pharmacol Sci. 103 (2): 201–6. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 17287588.
Dapyx Software network: MP3 Explorer | Ebook Manager | Zenithic