| Identifiers | |
| Symbol | CCND1 |
| Alt. Cyclin D Cyclin D1, also known as CCND1, is a human Gene. Cyclin D Cyclin D1, also known as CCND1, is a human Gene. Symbols | BCL1, D11S287E, PRAD1 |
| Entrez | 595 |
| HUGO | 1582 |
| OMIM | 168461 |
| RefSeq | NM_053056 |
| UniProt | P24385 |
| Other data | |
| Locus | Chr. 11 q13 |
| Identifiers | |
| Symbol | CCND2 |
| Entrez | 894 |
| HUGO | 1583 |
| OMIM | 123833 |
| RefSeq | NM_001759 |
| UniProt | P30279 |
| Other data | |
| Locus | Chr. 12 p13 |
| Identifiers | |
| Symbol | CCND3 |
| Entrez | 896 |
| HUGO | 1585 |
| OMIM | 123834 |
| RefSeq | NM_001760 |
| UniProt | P30281 |
| Other data | |
| Locus | Chr. 6 p21 |
Cyclin D is a member of the cyclin family, and comprises three closely related proteins, cyclin D1, D2 and D3. The Entrez Global Query Cross-Database Search System is a powerful Federated search engine or Web portal that allows users to search many discrete Health sciences The Human Genome Organisation (HUGO is an organization involved in the Human Genome Project, a project about mapping the human genome The Mendelian Inheritance in Man project is a Database that catalogues all the known Diseases with a genetic component, and—when possible—links them The National Center for Biotechnology Information ( NCBI) is part of the United States National Library of Medicine (NLM a branch of the National Institutes Swiss-Prot is a manually curated Biological database of Protein sequences In the fields of Genetics and Evolutionary computation, a locus (plural loci) is a fixed position on a Chromosome such as the position of a Chromosome 11 is one of the 23 pairs of Chromosomes in Humans People normally have two copies of this chromosome Cyclin D2, also known as CCND2, is a human Gene. Cyclin D2, also known as CCND2, is a human Gene. The Entrez Global Query Cross-Database Search System is a powerful Federated search engine or Web portal that allows users to search many discrete Health sciences The Human Genome Organisation (HUGO is an organization involved in the Human Genome Project, a project about mapping the human genome The Mendelian Inheritance in Man project is a Database that catalogues all the known Diseases with a genetic component, and—when possible—links them The National Center for Biotechnology Information ( NCBI) is part of the United States National Library of Medicine (NLM a branch of the National Institutes Swiss-Prot is a manually curated Biological database of Protein sequences In the fields of Genetics and Evolutionary computation, a locus (plural loci) is a fixed position on a Chromosome such as the position of a Chromosome 12 is one of the 23 pairs of Chromosomes in Humans People normally have two copies of this chromosome Cyclin D3, also known as CCND3, is a human Gene. The Entrez Global Query Cross-Database Search System is a powerful Federated search engine or Web portal that allows users to search many discrete Health sciences The Human Genome Organisation (HUGO is an organization involved in the Human Genome Project, a project about mapping the human genome The Mendelian Inheritance in Man project is a Database that catalogues all the known Diseases with a genetic component, and—when possible—links them The National Center for Biotechnology Information ( NCBI) is part of the United States National Library of Medicine (NLM a branch of the National Institutes Swiss-Prot is a manually curated Biological database of Protein sequences In the fields of Genetics and Evolutionary computation, a locus (plural loci) is a fixed position on a Chromosome such as the position of a Chromosome 6 is one of the 23 pairs of Chromosomes in Humans People normally have two copies of this chromosome Cyclins are a family of Proteins involved in the progression of cells through the Cell cycle. Proteins are large Organic compounds made of Amino acids arranged in a linear chain and joined together by Peptide bonds between the Carboxyl These are expressed in an overlapping, redundant fashion in all proliferating cell types and collectively control the progression of cells through the cell cycle. The cell is the structural and functional unit of all known living Organisms It is the smallest unit of an organism that is classified as living and is often called The cell cycle, or cell-division cycle, is the series of events that take place in a eukaryotic cell leading to its replication Since the D-cyclins are essential to cell division, they are also dysregulated in cancer. Cancer (medical term Malignant Neoplasm) is a class of Diseases in which a group of cells display uncontrolled
Cyclin D1
Cyclin D1 belongs to the family of cyclin proteins which function as the regulatory subunits of cyclin/cyclin dependent kinase (Cdk) holoenzymes that regulate entry into and progression through the cell cycle. Cyclin D1 expression is induced upon stimulation by growth factors (e. g. EGF, IGF-I/II), amino acids, hormones, and oncogenes such as Ras, Src, ErbB2, and SV40 T antigen. Cdk4 and Cdk6 can partner with Cyclin D1 in early to mid-G1 phase to phosphorylate and inactivate the cell-cycle inhibitory function of the retinoblastoma protein (pRB) in cooperation with Cyclin E/Cdk2. Cyclin D1 is also known to modulate local chromatin structure and transcription of genes involved in proliferation and differentiation through CDK-independent association with histone acetylases (e. g. CBP, P/CAF) and deacetylases. Amplification or overexpression of Cyclin D1 is important in the development of many cancers including parathyroid adenoma,breast,prostate and colon cancers,lymphoma and melanoma.
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