| Connexin-43 internal ribosome entry site (IRES) | ||||||||||
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The connexin-43 internal ribosome entry site (IRES) is an RNA element present in the 5' UTR of the mRNA of connexin-43 and allows cap-independent translation. Nucleotides are Organic compounds that consist of three joined structures a nitrogenous base a Sugar, and a Phosphate group A cis-regulatory element or cis-element is a region of DNA or RNA that regulates the expression of Genes located on that same strand The five prime untranslated region ( 5' UTR) also known as the leader sequence, is a particular section of Messenger RNA (mRNA and the DNA that codes for Messenger ribonucleic acid ( mRNA) is a molecule of RNA encoding a chemical "blueprint" for a Protein product Connexin 43 is a Connexin Gap junction found in the Heart and Brain that is known to bind tubulin at its Carboxyl Terminus and possibly at its The connexin-43 internal ribosome entry site (IRES) allows cap independent translation during conditions such as heat shock and stress. An internal Ribosome entry site, abbreviated IRES, is a Nucleotide sequence that allows for translation initiation in the middle of a Messenger [1]
References
- ^ Schiavi, A; Hudder A, Werner R (1999). "Connexin43 mRNA contains a functional internal ribosome entry site". FEBS Lett 464: 118–122. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 10618489.
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