In enzymology, a citrate (Re)-synthase (EC 2.3.3.3) is an enzyme that catalyzes the chemical reaction
- acetyl-CoA + H2O + oxaloacetate
citrate + CoA
The 3 substrates of this enzyme are acetyl-CoA, H2O, and oxaloacetate, whereas its two products are citrate and CoA. Enzymes are Biomolecules that catalyze ( ie increase the rates of Chemical reactions Almost all enzymes are Proteins This article is about the Enzyme Commission codes For the European Commission system for coding chemicals see EC-No. Enzymes are Biomolecules that catalyze ( ie increase the rates of Chemical reactions Almost all enzymes are Proteins Catalysis is the process in which the rate of a Chemical reaction is increased by means of a Chemical substance known as a catalyst A chemical reaction is a process that always results in the interconversion of Chemical substances The substance or substances initially involved in a chemical reaction are called Acetyl-CoA is an important molecule in metabolism used in many biochemical reactions Water is a common Chemical substance that is essential for the survival of all known forms of Life. Oxaloacetic acid is an Organic compound with the chemical formula HO2CC(OCH2CO2H A product is a substance that forms as a result of a Biological - or Chemical reaction. A citrate can refer either to the Conjugate base of Citric acid, (C3H5O(COO33&minus or to the Esters of citric Coenzyme A ( CoA, CoASH, or HSCoA) is a Coenzyme, notable for its role in the synthesis and oxidation of Fatty acids
This enzyme belongs to the family of transferases, specifically those acyltransferases that convert acyl groups into alkyl groups on transfer. In Biochemistry, a transferase is an Enzyme that catalyzes the transfer of a Functional group (e Acyltransferase is a type of Transferase Enzyme which acts upon Acyl groups The systematic name of this enzyme class is acetyl-CoA:oxaloacetate C-acetyltransferase [thioester-hydrolysing, (pro-R)-carboxymethyl-forming]. Other names in common use include (R)-citrate synthase, Re-citrate-synthase, and citrate oxaloacetate-lyase [(pro-3R)-CH2COO-->acetyl-CoA].
References
- IUBMB entry for 2.3.3.3
- BRENDA references for 2.3.3.3 (Recommended. )
- PubMed references for 2.3.3.3
- PubMed Central references for 2.3.3.3
- Google Scholar references for 2.3.3.3
- Dittbrenner S, Chowdhury AA, Gottschalk G (1969). "The stereospecificity of the (R)-citrates synthase in the presence of p-chloromercuribenzoate". Biochem. Biophys. Res. Commun. 36: 802–8. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 5808294.
- Gottschalk G (1969). "Partial purification and some properties of the (R)-citrate synthase from Clostridium acidi-urici". Eur. J. Biochem. 7: 301–6. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 4974734.
- Gottschalk G, Barker HA (1966). "Synthesis of glutamate and citrate by Clostridium kluyveri. A new type of citrate synthase". Biochemistry. 5: 1125–33. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 5958189.
External links
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- The CAS registry number for this enzyme class is 9077-70-7. CAS registry numbers are unique numerical identifiers for Chemical compounds Polymers biological sequences mixtures and Alloys They are also referred to