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calcitonin receptor-like receptor
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| Identifiers | |
| Symbol | CALCRL |
| Entrez | 10203 |
| HUGO | 16709 |
| OMIM | 114190 |
| RefSeq | NM_005795 |
| UniProt | Q16602 |
| Other data | |
| Locus | Chr. 2 q21.1-21.3 |
The calcitonin gene-related peptide receptors consist of a 7-transmembrane G-protein coupled, calcitonin receptor-like receptor (CL) linked to one of three single transmembrane domain receptor activity-modifying proteins (RAMPs) that are essential for functional activity. The Entrez Global Query Cross-Database Search System is a powerful Federated search engine or Web portal that allows users to search many discrete Health sciences The Human Genome Organisation (HUGO is an organization involved in the Human Genome Project, a project about mapping the human genome The Mendelian Inheritance in Man project is a Database that catalogues all the known Diseases with a genetic component, and—when possible—links them The National Center for Biotechnology Information ( NCBI) is part of the United States National Library of Medicine (NLM a branch of the National Institutes Swiss-Prot is a manually curated Biological database of Protein sequences In the fields of Genetics and Evolutionary computation, a locus (plural loci) is a fixed position on a Chromosome such as the position of a Chromosome 2 is one of the 23 pairs of Chromosomes in Humans People normally have two copies of this chromosome G protein-coupled receptors ( GPCRs) also known as seven transmembrane domain receptors, 7TM receptors, heptahelical receptors, and The calcitonin receptor is a G protein-coupled receptor which binds the peptide hormone Calcitonin and is involved in maintenance of Calcium Homeostasis Receptor activity-modifying proteins ( RAMP s are a class of proteins which interact with and modulate the activities of several Class B G Protein-Coupled
The association of CL with different RAMP proteins produces different receptors:
- with RAMP1: produces a CGRP receptor
- with RAMP2: produces an Adrenomedullin receptor
- with RAMP3: produces a dual CGRP/AM receptor
These receptors are linked to the G protein Gs[1], which activates adenylate cyclase and activation results in the generation of intracellular cyclic adenosine monophosphate (cAMP). Receptor activity-modifying proteins ( RAMP s are a class of proteins which interact with and modulate the activities of several Class B G Protein-Coupled Calcitonin gene related peptide (CGRP is derived with Calcitonin, from the CT/CGRP gene located on Chromosome 11. Receptor activity-modifying proteins ( RAMP s are a class of proteins which interact with and modulate the activities of several Class B G Protein-Coupled REDIRECT GPR182 Receptor activity-modifying proteins ( RAMP s are a class of proteins which interact with and modulate the activities of several Class B G Protein-Coupled GTP chemical structurepng|thumb|180px| Guanosine triphosphate]] G proteins short for guanine nucleotide-binding proteins, are a family of Proteins involved The Gs alpha subunit (or Gs protein) is a Heterotrimeric G protein subunit which activates Adenylate cyclase. Adenylate cyclase ( also known as adenylyl cyclase or AC) is a Lyase Enzyme. Not to be confused with Intercellular, meaning "between cells" Cyclic adenosine monophosphate ( cAMP, cyclic AMP or 3'-5'-cyclic Adenosine monophosphate) is a Second messenger that is important in many biological
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