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CUG triplet repeat, RNA binding protein 2
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| PDB rendering based on 2cpz. The Protein Data Bank ( PDB) is a repository for 3-D structural data of Proteins and Nucleic acids These data typically obtained by X-ray crystallography | ||
| Available structures: 2cpz | ||
| Identifiers | ||
| Symbol(s) | CUGBP2; BRUNOL3; ETR-3; NAPOR | |
| External IDs | OMIM: 602538 MGI: 1338822 HomoloGene: 4783 | |
| RNA expression pattern | ||
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| Orthologs | ||
| Human | Mouse | |
| Entrez | 10659 | 14007 |
| Ensembl | ENSG00000048740 | ENSMUSG00000002107 |
| Refseq | NM_001025076 (mRNA) NP_001020247 (protein) |
NM_183219 (mRNA) NP_899042 (protein) |
| Location | Chr 10: 11.25 - 11.42 Mb | Chr 2: 6.46 - 6.8 Mb |
| Pubmed search | [1] | [2] |
CUG triplet repeat, RNA binding protein 2, also known as CUGBP2, is a human gene. The Human Genome Organisation (HUGO is an organization involved in the Human Genome Project, a project about mapping the human genome The Mouse Genome Informatics (MGI website is run by The Jackson Laboratory. HomoloGene, a tool of the National Center for Biotechnology Information (NCBI is a system for automated detection of homologs (similarity attributable to descent The Entrez Global Query Cross-Database Search System is a powerful Federated search engine or Web portal that allows users to search many discrete Health sciences Ensembl is a joint scientific project between the European Bioinformatics Institute and the Wellcome Trust Sanger Institute, which was launched in 1999 in response to the imminent PubMed is a free search engine for accessing the MEDLINE database of citations and abstracts of biomedical research articles History See also History of genetics The existence of genes was first suggested by Gregor Mendel (1822-1884 who in the 1860s studied inheritance [1]
Members of the CELF/BRUNOL protein family contain two N-terminal RNA recognition motif (RRM) domains, one C-terminal RRM domain, and a divergent segment of 160-230 aa between the second and third RRM domains. Members of this protein family regulate pre-mRNA alternative splicing and may also be involved in mRNA editing, and translation. Alternative splicing results in multiple transcript variants encoding different isoforms. [1]
References
Further reading
- Hwang DM, Hwang WS, Liew CC (1995). "Single pass sequencing of a unidirectional human fetal heart cDNA library to discover novel genes of the cardiovascular system. ". J. Mol. Cell. Cardiol. 26 (10): 1329–33. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 7869393.
- Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery. ". Genome Res. 6 (9): 791–806. PMID 8889548.
- Lu X, Timchenko NA, Timchenko LT (1999). "Cardiac elav-type RNA-binding protein (ETR-3) binds to RNA CUG repeats expanded in myotonic dystrophy. ". Hum. Mol. Genet. 8 (1): 53–60. PMID 9887331.
- Choi DK, Ito T, Tsukahara F, et al. (1999). "Developmentally-regulated expression of mNapor encoding an apoptosis-induced ELAV-type RNA binding protein. ". Gene 237 (1): 135–42. PMID 10524244.
- Good PJ, Chen Q, Warner SJ, Herring DC (2000). "A family of human RNA-binding proteins related to the Drosophila Bruno translational regulator. ". J. Biol. Chem. 275 (37): 28583–92. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 10893231.
- Ladd AN, Charlet N, Cooper TA (2001). "The CELF family of RNA binding proteins is implicated in cell-specific and developmentally regulated alternative splicing. ". Mol. Cell. Biol. 21 (4): 1285–96. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 11158314.
- Li D, Bachinski LL, Roberts R (2001). "Genomic organization and isoform-specific tissue expression of human NAPOR (CUGBP2) as a candidate gene for familial arrhythmogenic right ventricular dysplasia. ". Genomics 74 (3): 396–401. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 11414768.
- Anant S, Henderson JO, Mukhopadhyay D, et al. (2002). "Novel role for RNA-binding protein CUGBP2 in mammalian RNA editing. CUGBP2 modulates C to U editing of apolipoprotein B mRNA by interacting with apobec-1 and ACF, the apobec-1 complementation factor. ". J. Biol. Chem. 276 (50): 47338–51. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 11577082.
- Lichtner P, Attié-Bitach T, Schuffenhauer S, et al. (2003). "Expression and mutation analysis of BRUNOL3, a candidate gene for heart and thymus developmental defects associated with partial monosomy 10p. ". J. Mol. Med. 80 (7): 431–42. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 12110949.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. ". Proc. Natl. Acad. Sci. U. S. A. 99 (26): 16899–903. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 12477932.
- Mukhopadhyay D, Houchen CW, Kennedy S, et al. (2003). "Coupled mRNA stabilization and translational silencing of cyclooxygenase-2 by a novel RNA binding protein, CUGBP2. ". Mol. Cell 11 (1): 113–26. PMID 12535526.
- Singh G, Charlet-B N, Han J, Cooper TA (2004). "ETR-3 and CELF4 protein domains required for RNA binding and splicing activity in vivo. ". Nucleic Acids Res. 32 (3): 1232–41. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 14973222.
- Mukhopadhyay D, Jung J, Murmu N, et al. (2004). "CUGBP2 plays a critical role in apoptosis of breast cancer cells in response to genotoxic injury. ". Ann. N. Y. Acad. Sci. 1010: 504–9. PMID 15033780.
- Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. ". Nat. Biotechnol. 22 (6): 707–16. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 15146197.
- Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. ". Genome Res. 14 (9): 1711–8. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 15342556.
- Murmu N, Jung J, Mukhopadhyay D, et al. (2004). "Dynamic antagonism between RNA-binding protein CUGBP2 and cyclooxygenase-2-mediated prostaglandin E2 in radiation damage. ". Proc. Natl. Acad. Sci. U. S. A. 101 (38): 13873–8. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 15358864.
- Han J, Cooper TA (2005). "Identification of CELF splicing activation and repression domains in vivo. ". Nucleic Acids Res. 33 (9): 2769–80. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 15894795.
- Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. ". Genome Res. 16 (1): 55–65. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 16344560.
- Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. ". Cell 125 (4): 801–14. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 16713569.
- Chen Z, Eggerman TL, Patterson AP (2007). "ApoB mRNA editing is mediated by a coordinated modulation of multiple apoB mRNA editing enzyme components. ". Am. J. Physiol. Gastrointest. Liver Physiol. 292 (1): G53–65. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 16920700.
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